Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice [PDF]
The Journal of Clinical InvestigationLeukemia relapse is a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). We tested the potential of targeting T cell (Tc) immunoglobulin and mucin-containing molecule 3 (TIM-3) for improving graft-versus-leukemia (GVL ...
Nana Talvard-Balland +41 more
doaj +10 more sources
The Role of TIM-3 in Glioblastoma Progression [PDF]
CellsSeveral immunoregulatory or immune checkpoint receptors including T cell immunoglobulin and mucin domain 3 (TIM-3) have been implicated in glioblastoma progression.
Farah Ahmady +4 more
doaj +4 more sources
Differential impact of TIM-3 ligands on NK cell function [PDF]
Journal for ImmunoTherapy of CancerBackground The transmembrane protein T-cell immunoglobulin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor that is expressed by a variety of leukocyte subsets, particularly in the tumor microenvironment. An effective TIM-3-
Xin Zhang +13 more
doaj +3 more sources
The role of TIM-3 in sepsis: a promising target for immunotherapy? [PDF]
Frontiers in ImmunologySepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune ...
Changli Wang +5 more
doaj +3 more sources
TIM-3 teams up with PD-1 in cancer immunotherapy: mechanisms and perspectives. [PDF]
Mol BiomedImmunotherapy using immune checkpoint inhibitors (ICIs) has become a prominent strategy for cancer treatment over the past ten years. However, the efficacy of ICIs remains limited, with certain cancers exhibiting resistance to these therapeutic ...
Yan Z, Wang C, Wu J, Wang J, Ma T.
europepmc +2 more sources
Transcriptomic Profiling of Tumor-Infiltrating CD4+TIM-3+ T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients [PDF]
Vaccines, 2020 T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME).
Varun Sasidharan Nair +10 more
doaj +4 more sources
IMMUNOLOGICAL ASPECTS OF CROHN’S DISEASE: A REGULATORY FUNCTION OF TIM-3/ GALECTIN-9 IN LYTH1 [PDF]
Euromediterranean Biomedical Journal, 2017 Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic and environmental factors.
Francesco Carini
doaj +3 more sources
Tim-3 mediates T cell trogocytosis to limit antitumor immunity
The Journal of Clinical Investigation, 2022 T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer immunity, we evaluated the effects of Tim-3 blockade in human and mouse melanoma ...
Ornella Pagliano +32 more
doaj +2 more sources
Redox BiologyT-cell immunoglobulin domain and mucin domain-3 (Tim-3) is a versatile immunomodulator that protects against intestinal inflammation. Necroptosis is a type of cell death that regulates intestinal homeostasis and inflammation.
Fangfei Wang +10 more
doaj +2 more sources
TIM-3 Promotes Proliferation of Acute Myeloid Leukemia Blasts [PDF]
BiomedicinesBackground: The immunocheckpoint TIM-3 is also expressed on acute myeloid leukemia (AML) blasts. Its prognostic significance requires clarification through subgroup analysis, while its functional roles and underlying mechanisms remain to be further ...
Zong-Yan Shi +4 more
doaj +2 more sources