Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice [PDF]
The Journal of Clinical InvestigationLeukemia relapse is a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). We tested the potential of targeting T cell (Tc) immunoglobulin and mucin-containing molecule 3 (TIM-3) for improving graft-versus-leukemia (GVL ...
Nana Talvard-Balland +41 more
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The Role of TIM-3 in Glioblastoma Progression [PDF]
CellsSeveral immunoregulatory or immune checkpoint receptors including T cell immunoglobulin and mucin domain 3 (TIM-3) have been implicated in glioblastoma progression.
Farah Ahmady +4 more
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Transcriptomic Profiling of Tumor-Infiltrating CD4+TIM-3+ T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients [PDF]
Vaccines, 2020 T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME).
Varun Sasidharan Nair +10 more
doaj +4 more sources
IMMUNOLOGICAL ASPECTS OF CROHN’S DISEASE: A REGULATORY FUNCTION OF TIM-3/ GALECTIN-9 IN LYTH1 [PDF]
Euromediterranean Biomedical Journal, 2017 Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic and environmental factors.
Francesco Carini
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TIM-3 Promotes Proliferation of Acute Myeloid Leukemia Blasts [PDF]
BiomedicinesBackground: The immunocheckpoint TIM-3 is also expressed on acute myeloid leukemia (AML) blasts. Its prognostic significance requires clarification through subgroup analysis, while its functional roles and underlying mechanisms remain to be further ...
Zong-Yan Shi +4 more
doaj +2 more sources
Differential impact of TIM-3 ligands on NK cell function [PDF]
Journal for ImmunoTherapy of CancerBackground The transmembrane protein T-cell immunoglobulin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor that is expressed by a variety of leukocyte subsets, particularly in the tumor microenvironment. An effective TIM-3-
Xin Zhang +13 more
doaj +2 more sources
Power Imbalance in Collaboration Relationships [PDF]
International Journal of Supply and Operations Management, 2016 Power plays a significant role in many organizational theories such as resource dependency theory and transaction cost economics. It allows the strong companies to win more than others, or more broadly, to coerce others to do what they would not ...
Driss Essabbar +2 more
doaj +3 more sources
Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. [PDF]
PLoS ONE, 2016 NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in maintaining immune tolerance during pregnancy. The mechanisms that facilitate NK cells tolerance to fetal tissue are largely unknown.
Jintang Sun +9 more
doaj +1 more source
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. [PDF]
PLoS ONE, 2012 T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted CD8(+) T cells in both chronic infection and tumor. However, the nature of TIM-3(+)CD4(
Xin Gao +9 more
doaj +1 more source
Expression of inhibitory receptors PD-1, CTLA-4, and Tim-3 by peripheral T cells during pregnancy
Бюллетень сибирской медицины, 2022 Background. Inhibitory receptors and their ligands (also called checkpoint molecules) are important feedback regulators of the immune response. However, their role in immunological adaptation during pregnancy remains poorly understood.The aim of the ...
E. A. Smetanenko +6 more
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