Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy : TIM-3/galectin-9 interaction and its possible role during pregnancy [PDF]
, 2014 Problem: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the
Bogár, Barbara +6 more
core +1 more source
Dok-3 deficient mice display different immune clustering and Tim-3 expression
European Journal of Medical Research, 2019 Background Dok-3 has been shown to play an important role in immune system. Tim-3 also has been recognized as an important immune regulator which involves in many diseases. The relationship of them is still unclear.
Wenjiang Yan +7 more
doaj +1 more source
Association of TIM-3 expression with glucose metabolism in Jurkat T cells
BMC Immunology, 2020 Background T cell activation is associated with increase in glycolysis and glutaminolysis. T cell immunoglobulin and mucin domain containing protein-3 (TIM-3), a T cell surface molecule, downregulates T cell activation and leads to insufficient immunity ...
Mi Jin Lee +6 more
doaj +1 more source
TIM-3 does not act as a receptor for galectin-9. [PDF]
PLoS Pathogens, 2013 T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and galectin-9 was described as
Judith Leitner +5 more
doaj +1 more source
Tim-3 expression on peripheral T cell subsets correlates with disease progression in hepatitis B infection [PDF]
, 2011 Background and objective T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) represents a novel mechanism of T-cell dysfunction in chronic viral diseases. However, the role of Tim-3 in the pathogenesis of chronic hepatitis B (CHB)
Wei Wu +5 more
core +1 more source
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]
, 2016 Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Abdel-Mohsen, Mohamed +17 more
core +8 more sources
Tim-3 expression in cervical cancer promotes tumor metastasis.
PLoS ONE, 2013 BackgroundT cell immunoglobulin mucin-3 (Tim-3) has been identified as a negative regulator of anti-tumor immunity. Recent studies highlight the important role of Tim-3 in the CD8(+) T cell exhaustion that takes place in both human and animal cancer ...
Yang Cao +7 more
doaj +1 more source
TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. [PDF]
PLoS ONE, 2015 TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells.
Brian Tomkowicz +11 more
doaj +1 more source
Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population [PDF]
, 2016 Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in ...
Alesahebfosoul, Fereshteh. +9 more
core +1 more source
Biomolecules & Biomedicine, 2023 The use of immune checkpoint inhibitors in malignant tumors improves patient outcomes. Because single-agent immune checkpoint blockade has a low objective response rate, it is meaningful to explore combined blockade of immune checkpoint receptors.
Xiaolin Xie +6 more
doaj +1 more source