Results 91 to 100 of about 1,659,892 (314)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Weighted Time-Delay Estimation-Based Proportional-Integral-Derivative Control for High-Order Time-Delay Nonlinear Systems

open access: yesIEEE Access
In real-world applications, time delays and uncertain nonlinearities are inevitable and impose significant challenges in modern control systems. The uncertainties commonly include nonlinear backlash-like hysteresis, external disturbances, parameter ...
Syeda Nadiah Fatima Nahri   +5 more
doaj   +1 more source

On the Genericity of Stabilizability for Time-Delay Systems [PDF]

open access: yesSIAM Journal on Control and Optimization, 1996
The stabilizability of linear delay systems of the form \[ \dot x(t)= A(\sigma)x(t)+ B(\sigma)u(t) \] where \[ (\sigma y)(t)= y(t-\tau) \] and \(A(s)\in \mathbb{R}[s]^{n\times n}\), \(B(s)\in \mathbb{R}[s]^{n\times m}\) is shown to be generic in the sense that such systems are open and dense in the space \[ V=\{(A(s),B(s),\tau): A(s)\in \mathbb{R}[s ...
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Robust H∞ control for a class of nonlinear discrete time-delay stochastic systems with missing measurements

open access: yes, 2009
This is the post print version of the article. The official published version can be obtained from the link - Copyright 2009 Elsevier LtdThis paper is concerned with the problem of robust H∞ output feedback control for a class of uncertain discrete-time ...
Liu, Y, Liu, X, Wang, Z, Ho, DWC
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

H∞ filtering for uncertain stochastic time-delay systems with sector-bounded nonlinearities

open access: yes, 2008
This is the post print version of the article. The official published version can be obtained from the link - Copyright 2008 Elsevier Ltd.In this paper, we deal with the robust H∞ filtering problem for a class of uncertain nonlinear time-delay stochastic
Liu, Y   +8 more
core   +1 more source

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