Results 61 to 70 of about 16,827 (243)

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Trade-off between responsiveness and noise suppression in biomolecular system responses to environmental cues. [PDF]

PLoS Computational Biology, 2011
When living systems detect changes in their external environment their response must be measured to balance the need to react appropriately with the need to remain stable, ignoring insignificant signals.
Alexander V Ratushny, Ilya Shmulevich, John D Aitchison   +2 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Comparison of time-frequency distribution techniques for analysis of spinal somatosensory evoked potential

, 2001
Spinal somatosensory evoked potential (SSEP) has been employed to monitor the integrity of the spinal cord during surgery. To detect both temporal and spectral changes in SSEP waveforms, an investigation of the application of time-frequency analysis (TFA)
Holmes, A, Leong, JCY, Hu, Y, Luk, KDK, Lu, WW   +4 more
core   +1 more source

Multidimensional Signal Analysis

, 2021
This chapter discusses signal characteristics in multiple domains, leading to the concept of multidimensional signal analysis. Multidimensional signal analysis is referred for analyzing the received radio signal from multiple dimensions jointly or ...
Hüseyin Arslan, Arslan, Hüseyin
core   +1 more source

QTFN: A General End-to-End Time-Frequency Network to Reveal the Time-Varying Signatures of the Time Series

Big Data Mining and Analytics
Nonstationary time series are ubiquitous in almost all natural and engineering systems. Capturing the time-varying signatures from nonstationary time series is still a challenging problem for data mining.
Tao Chen, Yang Jiao, Lei Xie, Hongye Su
doaj   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Robust Generalized Transient-Extracting Transform for Time–Frequency Feature Extraction

Fractal and Fractional
Time–frequency analysis (TFA) facilitates the extraction of instantaneous frequency (IF) features from non-stationary signals. Transient Extraction Transform (TET) produces highly concentrated time–frequency representations (TFRs) for pulse-like fault ...
Junbo Long, Dongyun Luo, Daifeng Zha, Honglian Wu, Tong Shu, Hongshe Fan   +5 more
doaj   +1 more source

Gambus Hadhramaut: The Malaysian Malay Lute Tuning Retrieval

BioResources, 2023
This study identified elements in a simple homemade gambus from a local crafter using a scientific approach. The gambus was made from geronggang wood (Cratoxylum arborescens), a light Malaysian hardwood with pink sapwood, distinct from the heartwood with
Sinin Hamdan, Khairul Anwar Mohamad Said, Md. Rezaur Rahman, Marini Sawawi, Aaliyawani Ezzerin Sinin   +4 more
doaj   +2 more sources

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source