Results 71 to 80 of about 16,827 (243)

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

open access: yesAdvanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth   +10 more
wiley   +1 more source

Optimised time-frequency analysis for drone detection in a multi-signal environment [PDF]

open access: yes, 2021
The abuse of recreational drones has caused security issues, crimes, and privacy problems. Thus, drone detection is needed as evidence for law enforcement or support countermeasures such as radio jamming, and remote control override.
Chia, Chun Choon
core  

Temporal Interference Stimulation Enhances Neural Regeneration

open access: yesAdvanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti   +15 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

open access: yesAdvanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang   +13 more
wiley   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

open access: yesAdvanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao   +10 more
wiley   +1 more source

Time-Frequency Analysis of Electroencephalographic Activity in the Entorhinal cortex and hippocampus [PDF]

open access: yes, 1997
Oscillatory states in the Electroencephalogram (EEG) reflect the rhythmic synchronous activation in large networks of neurons. Time-frequency methods quantify the spectral content of the EEG as a function of time.
Xu, Yan
core  

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang   +10 more
wiley   +1 more source

Husimi function for time-frequency analysis in optical, microwave and plasmonics aplications [PDF]

open access: yes, 2017
Many real-world signals, occurring in everyday engineering practice are non-stationary, and as a result, their frequency components may change gradually or abruptly over time.
Davidović, Milena D.   +4 more
core  

Fluorescence Tuning of Carbon Dots from Red to Blue via UV‐Induced Photochemical Etching

open access: yesAdvanced Science, EarlyView.
A UV‐driven photochemical process enables continuous color evolution of carbon dots from red to blue using a single irradiation parameter. Progressive photoetching restructures graphitic domains and surface states, allowing full visible‐spectrum emission control.
Nanzhi Zheng   +6 more
wiley   +1 more source

Comparison of time-frequency analysis techniques in intraoperative somatosensory evoked potential (SEP) monitoring

open access: yes, 2002
Somatosensory evoked potentials (SEPs) can be monitored during spinal surgery to prevent possible spinal cord injury. In order to improve the reliability of SEP monitoring, an investigation of the application of various time-frequency analysis (TFA ...
Hu, Y   +7 more
core   +1 more source

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