Results 81 to 90 of about 16,901 (243)
Versatile Detection of Cellular Protein via Fluorescence Anisotropy
Advanced Science, EarlyView.Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang +12 more
wiley +1 more source
Husimi function for time-frequency analysis in optical, microwave and plasmonics aplications [PDF]
, 2017 Many real-world signals, occurring in everyday engineering practice are non-stationary, and as a result, their frequency components may change gradually or abruptly over time.
Davidović, Milena D. +4 more
core
Extracting Structural Information Using Time-Frequency Analysis of Protein NMR Data [PDF]
, 2001 High-throughput, data-directed computational protocols for Structural Genomics (or Proteomics) are required in order to evaluate the protein products of genes for structure and function at rates comparable to current gene-sequencing technology.
Bruce Randall Donald (5409077) +3 more
core +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
Advanced Science, EarlyView.Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou +16 more
wiley +1 more source
Advanced Science, EarlyView.A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming +9 more
wiley +1 more source
Time-frequency analysis with neural network classification for intracardiac arrhythmia recognition. [PDF]
, 1995 Implantable cardioverter defibrillators (ICDs) are capable of detecting potentially lethal cardiac arrhythmias, the major cause of sudden cardiac death, and providing corrective electrical therapy to suppress the abnormal rhythm. Appropriate therapy from
Yan, Ming-Chuan
core
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Advanced Science, EarlyView.Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang +10 more
wiley +1 more source
Early Fault Detection of Robotic Joints Based on Time–Frequency Analysis of Motor Current Signature [PDF]
Robotic joints, which are critical fixtures consisting of electrical motors, high-speed planetary gears, and low-speed cycloid wheels, are prone to friction and wear.
Song, Yuzhuo +7 more
core +1 more source