Results 61 to 70 of about 9,379,767 (301)
Time-resolved structural studies with serial crystallography: A new light on retinal proteins
Structural Dynamics, 2015 Structural information of the different conformational states of the two prototypical light-sensitive membrane proteins, bacteriorhodopsin and rhodopsin, has been obtained in the past by X-ray cryo-crystallography and cryo-electron microscopy.
Valérie Panneels +17 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Time-resolved studies on the collapse of magnesium atom foam in helium nanodroplets
New Journal of Physics, 2013 Magnesium atoms embedded in superfluid helium nanodroplets have been identified to arrange themselves in a metastable network, referred to as foam. In order to investigate the ionization dynamics of this unique structure with respect to a possible light ...
S Göde +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Small but mighty: the power of microcrystals in structural biology
IUCrJAdvancements in macromolecular crystallography, driven by improved sources and cryocooling techniques, have enabled the use of increasingly smaller crystals for structure determination, with microfocus beamlines now widely accessible. Initially developed
Courtney J. Tremlett +7 more
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Scientific Reports, 2017 Early stage pharmacological studies rely on in vitro methodologies for screening and testing compounds. Conventional assays based on endpoint measurements provide limited information because the lack in temporal resolution may not determine the ...
Ala A. Alhusban +3 more
doaj +1 more source
Imaging Electron Dynamics with Ultrashort Light Pulses: A Theory Perspective
Applied Sciences, 2018 A wide range of ultrafast phenomena in various atomic, molecular and condense matter systems is governed by electron dynamics. Therefore, the ability to image electronic motion in real space and real time would provide a deeper understanding of such ...
Daria Popova-Gorelova
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Nature Communications, 2019 While cuprous oxide is a promising solar-to-fuel conversion material, photoelectrochemical devices substantially underperform. Here, the authors use femtosecond time-resolved two-photon photoemission spectroscopy to correlate photoexcited electron ...
Mario Borgwardt +11 more
doaj +1 more source