Results 121 to 130 of about 2,402,623 (312)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Time-History Analysis of Frictionally Damped Structures
, 2011 During major seismic actions, a significant amount of energy is induced to structures. The means by which this energy is dissipated, determines the level of structural degradation. Special emphasis is placed on avoiding loss of human lives due to the earthquake action.
Ştefancu, Andrei-Ionuţ +2 more
openaire +1 more source
Studying time in organizational behavior
This article builds on the call of various authors (e.g. George & Jones, 2000; Mitchell & James,2001; Rousseau & Fried, 2001) for a better representation of time in theory-building andresearch in organizational behavior (OB).
Roe,Robert A.
core
Econometric Studies of Business Cycles in the History of Econometrics [PDF]
This study examines the evolution of econometric research in business cycle analysis during the 1960-90 period. It shows how the research was dominated by an assimilation of the tradition of NBER business cycle analysis by the Haavelmo-Cowles Commission ...
Duo Qin
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Seismic Design and Risk Analyses of Safe-to-Fail Steel and RC Frames for Nuclear Facilities
Jurnal Teknik SipilIn this article, the design and estimate of the collapse risk of safe-to-fail steel and reinforced concrete (RC) frames due to earthquakes were proposed. The frames are part of nuclear facility buildings, and their failures are to follow the safe-to-fail
Sindur P. Mangkoesoebroto +1 more
doaj
Real-time data and business cycle analysis in Germany [PDF]
This paper examines the consequences of using "real-time" data for business cycle analysis in Germany based on a novel data set covering quarterly real output data from 1968 to 2001. Real-time output gaps are calculated.
Döpke, Jörg
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source