Results 61 to 70 of about 166,423,695 (229)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Deep Learning-Based Travel Time Estimation in Hiking with Consideration of Individual Walking Ability

Cybernetics and Information Technologies
Hiking is popular, but mountain accidents are serious problems. Accurately predicting hiking travel time is an essential factor in preventing mountain accidents.
Asako Mizuho, Tahara Yasuyuki, Ohsuga Akihiko, Sei Yuichi   +3 more
doaj   +1 more source

Robust Blind Algorithm for DOA Estimation Using TDOA Consensus

Acoustics
This paper proposes a robust blind algorithm for direction of arrival (DOA) estimation in challenging acoustic environments. The method introduces a novel Time Difference of Arrival (TDOA) consensus framework that effectively identifies and filters ...
Danilo Greco
doaj   +1 more source

Approximate maximum likelihood estimation of two closely spaced sources [PDF]

, 2014
The performance of the majority of high resolution algorithms designed for either spectral analysis or Direction-of-Arrival (DoA) estimation drastically degrade when the amplitude sources are highly correlated or when the number of available snapshots is
Chaumette, Eric, Besson, Olivier, Vincent, François   +2 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

An Error Analysis Method for Correlation-Based Parameter Estimators in Discrete-Time Signals Under Gaussian Noise

IEEE Access
In this study, we expand on a previously introduced method for computing the error statistics associated with estimating the time of arrival of a known signal in sampled data with additive white Gaussian noise (AWGN).
Chris Hall, Ivan Djordjevic
doaj   +1 more source

A Novel Method for DOA and Time Delay Joint Estimation in Multipath OFDM Environment

International Journal of Antennas and Propagation, 2020
Joint time delay and direction of arrival estimation based on uniform linear arrays in Orthogonal Frequency Division Multiplexing (OFDM) systems has to face the problems posed by coherent multipath environments and high computational complexity.
Xiangzhi Li, Weijia Cui, Haiyun Xu, Bin Ba, Yankui Zhang   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Space-time division cluster DoA estimation algorithm based on UWA spread spectrum signal

Tongxin xuebao, 2022
To solve the problems of poor stability, low resolution, and performance degradation under low signal-to-noise ratio (SNR) of the direction of arrival (DoA) estimation, a space-time division cluster (STDC) DoA estimation algorithm was proposed for under ...
Feng ZHOU, Baosheng ZHANG, Wenbo ZHANG
doaj   +2 more sources