Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Effects of Risk and Time Preferences on Diet Quality: Empirical Evidence from Rural Madagascar
FoodsMalnutrition is a major concern in Madagascar. Eating a wide variety of nutritious food is necessary because Malagasy diets heavily rely on rice consumption.
Sakiko Shiratori +4 more
doaj +1 more source
Indecisiveness on risk preference and time preference choices. Does financial literacy matter?
Cogent Psychology, 2019 The aim of this study is to investigate the relationship between financial literacy and decisiveness in making risk preference and time preference choices by university students.
Calvin Mudzingiri +3 more
doaj +1 more source
Sign-dependent Value of Time in Stated Preference: Judgment Bias or Exposure of Genuine Preference?
European Journal of Transport and Infrastructure Research, 2010 Stated choice surveys may be the most common approach to obtain monetary values of travel time. The large surveys of 1988 and 1997 in the Netherlands and of 1994 in the United Kingdom produced some puzzling outcomes, such as differences in monetary ...
Evert Jan van de Kaa
doaj +1 more source
Time Preference for Immediate Gratification: Associations With Low Medication Adherence and Uncontrolled Blood Pressure. [PDF]
Am J Hypertens, 2022 Krousel-Wood M +8 more
europepmc +1 more source
Discounting and the Social Time Preference Rate [PDF]
This paper shows that the emphasis on a social time preference rate (defined as the sum of a pure time preference rate and the product of the elasticity of marginal valuation and the growth rate) in social evaluations where money values are discounted ...
John Creedy
core
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Stated Preference Experiments Concerning Long Distance Business Travel in Great Britain [PDF]
, 1986 Stated preference techniques are now widely used in transport economics as an experimental tool for gathering data on consumer preferences to derive, amongst other things, estimates of demand elasticities and values of travel time, service frequency ...
Fowkes, A.S., Marks, P.
core