Results 131 to 140 of about 28,472 (205)

Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangiomas.

Journal of Drugs in Dermatology, 2023
BACKGROUND Oral propranolol is considered the first line therapy in the treatment of infantile hemangiomas (IHs). However, there are considerable side effects due to its ability to penetrate the blood brain barrier.
Farihah Anwar, E. Mahmood, Shawana Sharif, Rohan Shah, Marielle Jamgochian, S. Ouellette, Muhammad Umar, B. Rao   +7 more
semanticscholar   +1 more source

In Situ Gelling Electrospun Ocular Films Sustain the Intraocular Pressure-Lowering Effect of Timolol Maleate: In Vitro, Ex Vivo, and Pharmacodynamic Assessment.

Molecular Pharmaceutics, 2021
Most common intraocular pressure (IOP) reduction regimens for the management of glaucoma include the topical use of eye drops, a dosage form that is associated with short residence time at the site of action, increased dosing frequency, and reduced ...
I. Andreadis, C. Karavasili, Angelos L. N. Thomas, A. Komnenou, Manolis Tzimtzimis, D. Tzetzis, Dimitrios Andreadis, N. Bouropoulos, D. Fatouros   +8 more
semanticscholar   +1 more source

Effect of CYP2D6*4, CYP2D6*10 polymorphisms on the safety of treatment with timolol maleate in patients with glaucoma

Drug Metabolism and Personalized Therapy, 2022
Objectives Timolol maleate is used for the treatment of glaucoma and metabolized by cytochrome CYP2D6 in the liver. The aim of this study was the evaluation of the influence of CYP2D6*4 and CYP2D6*10 gene polymorphisms on the safety of medications ...
L. Moshetova, M. M. Soshina, Ksenia I. Turkina, E. Grishina, Z. Sozaeva, A. Kachanova, K. Akmalova, D. Ivashchenko, M. Zastrozhin, V. Fisenko, D. Sychev   +10 more
semanticscholar   +1 more source

Evaluation of timolol maleate gel for management of hard-to-heal chronic venous leg ulcers. Phase II randomised-controlled study.

Annales de dermatologie et de vénéréologie, 2021
BACKGROUND Venous leg ulcers (VLUs) often take a very long time to heal. Timolol maleate has been reported as displaying efficacy in healing of VLUs. OBJECTIVES To evaluate the efficacy of timolol maleate gel in the management of hard-to-heal VLUs and ...
T. Baltazard, P. Senet, D. Momar, C. Picard, C. Joachim, A. Adas, C. Lok, G. Chaby   +7 more
semanticscholar   +1 more source

Full Factorial Design for Development and Validation of a Stability-Indicating RP-HPLC Method for the Estimation of Timolol Maleate in Surfactant-Based Elastic Nano-Vesicular Systems.

Journal of Chromatographic Science, 2021
A novel isocratic stability-indicating chromatographic method was developed, optimized and validated using Design-Expert® following ICH guidelines for the quantification of Timolol maleate (TM).
Santosh Naik, P. Mullick, Sadhana P. Mutalik, A. Hegde, S. Lewis, K. Bhat, B. S. S. Rao, S. Mutalik   +7 more
semanticscholar   +1 more source

Timolol maleate in the control of myopia: A preliminary report

Acta Ophthalmologica, 1988
exaly   +3 more sources

A randomized, controlled, split‐face study of topical timolol maleate 0.5% eye drops for the treatment of erythematotelangiectatic rosacea

Journal of Cosmetic Dermatology, 2021
Centrofacial erythema associated with telangiectasis is the most common presentation of rosacea, known as erythematotelangiectatic rosacea (ETR). However, successful management of these symptoms remains challenging.
Danfeng Wei, Michael R Hamblin, Xiang Wen   +2 more
semanticscholar   +1 more source

Synthesis and characterization of timolol maleate-loaded quaternized chitosan-based thermosensitive hydrogel: A transparent topical ocular delivery system for the treatment of glaucoma.

International Journal of Biological Macromolecules, 2020
The chitosan-based thermosensitive hydrogel is one of the attractive in situ forming drug delivery systems that are suggested for ophthalmic applications.
Yousef Pakzad, M. Fathi, Y. Omidi, M. Mozafari, A. Zamanian   +4 more
semanticscholar   +1 more source

Thiolated gellan gum/polyethylene glycol diacrylate hydrogels containing timolol maleate-loaded chitosan nanoparticles for ophthalmic delivery

Biomedical Materials
The combination of hydrogels with nanoformulations can significantly enhance the delivery and effectiveness of drugs in ophthalmic drug delivery systems.
Golnaz Shajari, H. Erfan-Niya, M. Fathi, Nazanin Amiryaghoubi   +3 more
semanticscholar   +1 more source

In situ forming hydrogels based on modified gellan gum/chitosan for ocular drug delivery of timolol maleate.

International Journal of Biological Macromolecules
In situ forming hydrogels are suitable candidates for increasing drug residence time in ocular drug delivery. In this study, gellan gum (GG) was oxidized to form aldehyde groups and in situ gelling hydrogels were synthesized based on a Schiff-base ...
Golnaz Shajari, Hamid Erfan-Niya, M. Fathi, Nazanin Amiryaghoubi   +3 more
semanticscholar   +1 more source