TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLC [PDF]
CellsKirsten rat sarcoma viral oncogene homolog (KRAS) is one of the most frequently mutated genes in human cancer, including non-small cell lung carcinoma (NSCLC). Sustained expression of KRAS is required for survival in KRAS-dependent tumors.
Ilamathi M-Thirusenthilarasan +8 more
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The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity [PDF]
European Journal of Medical Research, 2023 Background Inflammation, oxidative stress and an imbalance between proteases and protease inhibitors are recognized pathophysiological features of chronic obstructive pulmonary disease (COPD).
Sanja Dimic-Janjic +12 more
doaj +2 more sources
Estrogen‐dependent gene regulation: Molecular basis of TIMP‐1 as a sex‐specific biomarker for acute lung injury [PDF]
Physiological ReportsIncreased circulating tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have been observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of TIMP‐1 and the underlying molecular mechanisms have not been well ...
Sultan Almuntashiri +14 more
doaj +2 more sources
The invariant chain CD74 protein is a cell surface binding partner of TIMP‐1 in breast cancer cells [PDF]
Molecular Oncology, 2023 Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) regulates the proteolytic activity of matrix metalloproteinases (MMPs), playing an important role in the homeostasis of the extracellular matrix.
Mikkel Høeberg +11 more
doaj +2 more sources
Levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are related to cardiopulmonary injury in fetal inflammatory response syndrome [PDF]
Clinics, 2020 OBJECTIVES: To evaluate the diagnostic value of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the MMP-9/TIMP-1 ratio in fetal inflammatory response syndrome (FIRS), and determine a possible association with the
Yiwei Yan +6 more
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Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1. [PDF]
PLoS ONE, 2013 Recently matrix metalloproteinase-9 (MMP-9) and its endogenous inhibitor (tissue inhibitor of metalloproteinase-1, TIMP-1) have been implicated in complicated malaria. In vivo, mice with cerebral malaria (CM) display high levels of both MMP-9 and TIMP-1,
Manuela Polimeni +6 more
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Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. [PDF]
, 2012 Mesothelial cells are critical in the pathogenesis of post-surgical intraabdominal adhesions as well as in the deterioration of the peritoneal membrane associated with long-term peritoneal dialysis.
Djafarzadeh, Roghieh +10 more
core +9 more sources
Zaporožskij Medicinskij Žurnal, 2020 Aim – to study the features of immunohistochemical expression of MMP-9, TIMP-1, MMP/TIMP ratio in the cerebral cortex in diabetes mellitus type 2. Materials and methods.
V. O. Shavrin , Yu. M. Avramenko
doaj +1 more source
Cells, 2023 Triple-negative breast cancer (TNBC) is among the most aggressive breast cancer subtypes. Despite being initially responsive to chemotherapy, patients develop drug-resistant and metastatic tumors.
Lisa Agnello +7 more
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Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients [PDF]
Arhiv za farmaciju, 2017 Matrix metaloproteinases (MMPs) and their specific inhibitors - tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs.
Ivanišević Jasmina +6 more
doaj +1 more source