TIMP-1 Promotes Accumulation of Cancer Associated Fibroblasts and Cancer Progression [PDF]
PLoS ONE, 2013 Treatment options for late stage prostate and colon cancer are limited and there is an urgent need to develop more effective and targeted novel therapies, which starts with identification and validation of novel therapeutic targets.
William K Oh
exaly +3 more sources
The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
European Journal of Medical Research, 2023 Background Inflammation, oxidative stress and an imbalance between proteases and protease inhibitors are recognized pathophysiological features of chronic obstructive pulmonary disease (COPD).
Sanja Dimic-Janjic +12 more
doaj +2 more sources
TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
Scientific Reports, 2017 Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix.
Nina D. Thiele +6 more
doaj +2 more sources
Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas
BMC Cancer, 2018 Background We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-binding protein, has been suggested to ...
Charlotte Aaberg-Jessen +6 more
doaj +2 more sources
TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2. [PDF]
PLoS ONE, 2015 Tissue inhibitors of metalloproteinases (TIMPs) are multifaceted molecules that exhibit properties beyond their classical proteinase inhibitory function.
Srilatha Nalluri +7 more
doaj +2 more sources
Scientific Reports, 2019 Liver fibrosis is characterised by a dense and highly cross-linked extracellular matrix (ECM) which promotes progression of diseases such as hepatocellular carcinoma. The fibrotic microenvironment is characterised by an increased stiffness, with rigidity
Dariusz Lachowski +2 more
exaly +2 more sources
TIMP-1 Induces α-Smooth Muscle Actin in Fibroblasts to Promote Urethral Scar Formation
Cellular Physiology and Biochemistry, 2015 Background/Aims: Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been reported to upregulate in urethral scar. However, the underlying molecular mechanisms remain undefined.
Yinglong Sa +3 more
doaj +2 more sources
Frontiers in Molecular Neuroscience, 2019 Unresolved inflammation is a significant predictor for developing chronic pain, and targeting the mechanisms underlying inflammation offers opportunities for therapeutic intervention.
Tamara King, Stephen J Crocker
exaly +2 more sources
TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice
Haematologica, 2015 The homeostasis of neutrophil granulocytes can affect the outcome of several inflammation-associated diseases including cancer. The regulation of this homeostasis is still not completely understood.
Julia Kobuch +5 more
doaj +2 more sources
Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2012 Tissue inhibitor of metalloproteinases 1 (TIMP-1) is a matrix metalloproteinase (MMP)-independent regulator of growth and apoptosis in various cell types.
Avalos +42 more
core +2 more sources