Results 1 to 10 of about 116,967 (120)

Levels of MMP2, TIMP1 and TIMP2 in Follicular Fluids in Women Undergoing in Vitro Fertilization and Their Relationship to Oocyte Quality [PDF]

Journal of Biomedical & Clinical Research, 2019
Recently, the important role of matrix metalloproteinases (MMPs) has been identified in follicular development and subsequent ovulation. Although the role of MMP in ovarian tissue remodeling during folliculogenesis has been well studied, the relationship
Nina Ayvazova, Lyubomira Ilieva, Emiliana Konova, Milena Atanasova   +3 more
doaj   +3 more sources

Nephrotoxicity Biomarkers: Role and Significance in the Diagnosis of Drug-Induced Kidney Injury

Безопасность и риск фармакотерапии, 2021
Drug-induced kidney injury (DIKI) accounts for 8 to 60% of episodes of acute kidney injury (AKI) among hospital patients. Early DIKI detection and timely adjustment of therapy will help reduce the kidney injury incidence and mortality.
O. V. Muslimova, V. A. Evteev, I. A. Mazerkina, E. A. Sokova, A. B. Prokofiev, A. V. Shapchenko, T. V. Alexandrova   +6 more
doaj   +1 more source

Single value of NephroCheck™ performed at 4 hours after surgery does not predict acute kidney injury in off-pump coronary artery bypass surgery

Annals of Cardiac Anaesthesia, 2023
Background: Quantification of urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein (IFGBP-7), which is commercially known as NephroCheck™(NC) test have been suggested as promising tools for the early ...
Muralidhar Kanchi, Karanam D Sudheshna, Srinath Damodaran, Vikneswaran Gunaseelan, Anup D Varghese, Kumar Belani   +5 more
doaj   +1 more source

TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression. [PDF]

PLoS ONE, 2012
TIMP-2 protein has been intensively studied as a promising anticancer candidate agent, but the in vivo mechanism underlying its anticancer effect has not been clearly elucidated by previous works.
Mi-Sook Lee, Jae-In Jung, Seung-Hae Kwon, Sang-Mok Lee, Kyoji Morita, Song Her   +5 more
doaj   +1 more source

The urine biomarker panel [IGFBP7]x[TIMP-2] (NephroCheck® parameter) does not correlate with IGFBP7 and TIMP-2 gene expression in urinary sediment. [PDF]

PLoS ONE, 2017
Acute kidney injury (AKI) is frequently observed in serious infections, following nephrotoxic medication, surgery and trauma. Here we tested whether the detection of two recently identified biomarkers for AKI, Tissue Inhibitor of Metalloproteinase-2 ...
Daniela Knafl, Markus Müller, Sahra Pajenda, Zeynep Genc, Manfred Hecking, Ludwig Wagner   +5 more
doaj   +1 more source

TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2. [PDF]

PLoS ONE, 2015
Tissue inhibitors of metalloproteinases (TIMPs) are multifaceted molecules that exhibit properties beyond their classical proteinase inhibitory function.
Srilatha Nalluri, Sampa Ghoshal-Gupta, Ammar Kutiyanawalla, Sitaram Gayatri, Byung Rho Lee, Shahanawaz Jiwani, Amyn M Rojiani, Mumtaz V Rojiani   +7 more
doaj   +1 more source

Cell cycle arrest biomarkers for the early detection of acute allograft dysfunction and acute rejection in living donor kidney transplantation: a cross-sectional study from Egypt

Korean Journal of Transplantation, 2023
Background : Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are G1 cell arrest biomarkers that have demonstrated accuracy and validity in predicting and diagnosing acute kidney injury ...
Mahmoud M. Elnokeety, Wessam Mustafa Hussein, Samar Ahmed Abdelrazek, Mohamed Momtaz   +3 more
doaj   +1 more source

TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9

Cell Adhesion & Migration, 2019
Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression of TIMP-2 and MMP-9 in a  CRC tissue microarray by immunohistochemistry.
Weimin Wang, Dan Li, Liangliang Xiang, Mengying Lv, Li Tao, Tengyang Ni, Jianliang Deng, Xiancheng Gu, Sunagawa Masatara, Yanqing Liu, Yan Zhou   +10 more
doaj   +1 more source

The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study

BMC Research Notes, 2021
Objective Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. They exhibit proteolytic activity implicating the efficiency of trophoblast invasion to the uterine wall involving marked hemodynamic and uterine ...
Ritva Nissi, Markku Santala, Anne Talvensaari-Mattila   +2 more
doaj   +1 more source

Effect of anti-tuberculosis treatment on the systemic levels of tissue inhibitors of metalloproteinases in tuberculosis – Diabetes co-morbidity

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2021
Objectives: To study the association of Tissue inhibitors of matrix metalloproteinases (TIMP) levels with tuberculosis-diabetes comorbidity (TB-DM) comorbidity at baseline and in response to anti-TB treatment (ATT).
Nathella Pavan Kumar, Kadar Moideen, Vijay Viswanathan, Shanmugam Sivakumar, Syed Hissar, Hardy Kornfeld, Subash Babu   +6 more
doaj   +1 more source