TIMP-2 and IGFBP7 in human kidney biopsies in renal disease. [PDF]
Clin Kidney J, 2023 ABSTRACT Background Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) are markers of tubular stress and urinary [TIMP-2]*[IGFBP7] is an established biomarker for risk assessment of acute kidney injury.
Schanz M +4 more
europepmc +4 more sources
Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) as a Prognostic Biomarker in Acute Kidney Injury: A Narrative Review [PDF]
DiagnosticsAcute kidney damage (AKI) is a serious and common consequence among critically unwell individuals. Traditional biomarkers, such as serum creatinine, frequently fail to detect AKI in its early stages, necessitating the development of new accurate early ...
Charlotte Delrue, Marijn M. Speeckaert
doaj +2 more sources
The Role of TIMP-2 Gene in Skin Cancer
Journal of Mazandaran University of Medical Sciences, 2017 Background and purpose: Skin cancer is one of the most common types of cancer. Several studies suggest a high incidence of skin cancer in most countries. TIMP-2 is the tissue inhibitor of matrix metalloproteinase and exist in both cancer and normal cells.
Negar Zoghaghi +2 more
doaj +1 more source
NephroCheck AKI risk scores (TIMP-2 and IGFBP7) in pregnancy. [PDF]
Nephrol Dial TransplantClark K +9 more
europepmc +3 more sources
Levels of MMP2, TIMP1 and TIMP2 in Follicular Fluids in Women Undergoing in Vitro Fertilization and Their Relationship to Oocyte Quality [PDF]
Journal of Biomedical & Clinical Research, 2019 Recently, the important role of matrix metalloproteinases (MMPs) has been identified in follicular development and subsequent ovulation. Although the role of MMP in ovarian tissue remodeling during folliculogenesis has been well studied, the relationship
Nina Ayvazova +3 more
doaj +3 more sources
Nephrotoxicity Biomarkers: Role and Significance in the Diagnosis of Drug-Induced Kidney Injury
Безопасность и риск фармакотерапии, 2021 Drug-induced kidney injury (DIKI) accounts for 8 to 60% of episodes of acute kidney injury (AKI) among hospital patients. Early DIKI detection and timely adjustment of therapy will help reduce the kidney injury incidence and mortality.
O. V. Muslimova +6 more
doaj +1 more source
Annals of Cardiac Anaesthesia, 2023 Background: Quantification of urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein (IFGBP-7), which is commercially known as NephroCheck™(NC) test have been suggested as promising tools for the early ...
Muralidhar Kanchi +5 more
doaj +1 more source
Cell surface binding of TIMP‐2 and pro‐MMP‐2/TIMP‐2 complex [PDF]
FEBS Letters, 1995 Tissue inhibitor of metalloproteinases (TIMP‐2) is a low molecular weight proteinase inhibitor capable of inhibiting activated matrix metalloproteinases (MMPs). TIMP‐2 is found both free and in a 1:1 stoichiometric complex with the pro‐enzyme form of MMP‐2 (pro‐MMP‐2/TIMP‐2 complex).
Emmert-Buck, M. R. +5 more
openaire +3 more sources
TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression. [PDF]
PLoS ONE, 2012 TIMP-2 protein has been intensively studied as a promising anticancer candidate agent, but the in vivo mechanism underlying its anticancer effect has not been clearly elucidated by previous works.
Mi-Sook Lee +5 more
doaj +1 more source
Inhibited Angiogenesis in Aging: A Role for TIMP-2 [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2003 Factors responsible for age-associated impairment of angiogenesis are poorly understood. We observed that in aged mice, new fibrovascular tissue within subcutaneous polyvinyl alcohol sponges expressed more tissue inhibitor of metalloproteinases (TIMP)-2 than did corresponding tissue from young mice.
Teruhiko, Koike +4 more
openaire +2 more sources