Results 111 to 120 of about 30,124 (283)

Cutaneous Squamous Cell Carcinoma Amongst Solid Organ Transplant Recipients: A Systematic Review of Molecular Alterations

JEADV Clinical Practice, EarlyView.
ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray, Robin Caird, Michael O'Connor, Ciara Drumm, Emma O'Hora, Franklin Crossen, Aoife Lally, Aurelie Fabre, Roisin Dolan   +8 more
wiley   +1 more source

Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancer

Biomolecular Concepts, 2011
Our review covers the recent epigenetic data that are focused on matrix metalloproteinases (MMPs), their inhibitors (tissue inhibitors of MMPs; TIMPs) and collagen substrates.
Chernov Andrei V., Strongin Alex Y.
doaj   +1 more source

Chronic tendon pathology: molecular basis and therapeutic implications [PDF]

, 2005
Tendons are frequently affected by chronic pain or rupture. Many causative factors have been implicated in the pathology, which until relatively recently was under-researched and poorly understood.
Riley, GP
core   +1 more source

E. coli Expression of TIMP-4 and Comparative Kinetic Studies with TIMP-1 and TIMP-2:  Insights into the Interactions of TIMPs and Matrix Metalloproteinase 2 (Gelatinase A)

Biochemistry, 2002
The inhibitory properties of TIMP-4 for matrix metalloproteinases (MMPs) were compared to those of TIMP-1 and TIMP-2. Full-length human TIMP-4 was expressed in E. coli, folded from inclusion bodies, and the active component was purified by MMP-1 affinity chromatography. Progress curve analysis of MMP inhibition by TIMP-4 indicated that association rate
Troeberg, Linda, Tanaka, Mitsuo, Wait, Robin, Shi, Yeunian E, Brew, Keith, Nagase, Hideaki   +5 more
openaire   +4 more sources

What Are the Limitations of Measuring Bladder Compliance, As the Sole Indicator of Future Risk to the Upper Urinary Tract and Renal Function? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Maintenance of bladder filling and urinary storage at low intravesical pressures is fundamental to minimizing risk to the upper urinary tract. Bladder compliance describes the relationship between the bladder volume and the change in detrusor pressure during the filling phase of urodynamics.
Eric Rovner, Marcus J. Drake, Solomon Eskinder, Andrew Gammie, Sanjay Sinha, John Speich   +5 more
wiley   +1 more source

Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium

Communications Medicine
Background The aetiology of delirium is not known, but pre-existing cognitive impairment is a predisposing factor. Here we explore the associations between delirium and cerebrospinal fluid (CSF) levels of matrix metalloproteinases (MMPs) and their tissue
Mari Aksnes, Mari Haavig Schibstad, Farrukh Abbas Chaudhry, Bjørn Erik Neerland, Gideon Caplan, Ingvild Saltvedt, Rannveig S. Eldholm, Marius Myrstad, Trine Holt Edwin, Karin Persson, Ane-Victoria Idland, Christian Thomas Pollmann, Roy Bjørkholt Olsen, Torgeir Bruun Wyller, Henrik Zetterberg, Emma Cunningham, Leiv Otto Watne   +16 more
doaj   +1 more source

Comparative gene expression profiling of ADAMs, MMPs, TIMPs, EMMPRIN, EGF-R and VEGFA in low grade meningioma [PDF]

, 2016
MMPs (matrix metalloproteinases), ADAMs (a disintegrin and metalloproteinase) and TIMPs (tissue inhibitors of metalloproteinases) are implicated in invasion and angiogenesis: both are tissue remodeling processes involving regulated proteolysis of the ...
Andrew J. Martin, Andrew King, Barresi, Barresi, Barresi, Bourboulia, Brew, Clark, Edwards, Geoffrey J. Pilkington, Gialeli, Hagemann, Hagemann, Harcharan K. Rooprai, Huw Jones, Kessenbrock, Kirches, Kodama, Lettau, Louis, Love, Murphy, Nagase, Nagashima, Nordqvist, Nuttall, Okada, Okuducu, Patel, Perry, Perry, Pistolesi, Qu, Richard P. Selway, Richard W. Gullan, Rocks, Rooprai, Roy, Saftig, Sarkar, Silveira Corrêa, Stojic, Toft-Hansen, Tsai, Usha D. Appadu, Van Meter, von Randow, Wang, Wernicke, Wildeboer   +49 more
core   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Matrix Metalloproteinases Contribute to Neuronal Dysfunction in Animal Models of Drug Dependence, Alzheimer's Disease, and Epilepsy

Biochemistry Research International, 2011
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors
Hiroyuki Mizoguchi, Kiyofumi Yamada, Toshitaka Nabeshima   +2 more
doaj   +1 more source