Results 81 to 90 of about 30,124 (283)
Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas [PDF]
British Journal of Cancer, 2001 Studies have suggested that an imbalance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) may contribute to the malignant phenotype of gliomas. In this study, we have undertaken a detailed analysis of expression of the TIMP family in normal human brain and malignant gliomas at both the mRNA and protein level ...
Groft, L.L. +7 more
openaire +3 more sources
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, ClinicalTrials.gov identifier ...
Andrea Fava +8 more
wiley +1 more source
HERVs, transposons and human diseases : part I [PDF]
, 2012 Part 2 and part 3 of the article can be found through this link: https://www.um.edu.mt/library/oar//handle/123456789/13012 https://www.um.edu.mt/library/oar//handle/123456789/13132It has been found that the human genome is full of relic retroviral ...
Baldacchino, Sandra, Grech, Alfred
core +2 more sources
Journal of Education, Health and Sport, 2019 Introduction: Pituitary adenomas are generally benign central nervous system neoplasms with still increasing prevalence, especially in younger people.
Joanna Szydełko +2 more
doaj +3 more sources
Expression of Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Tonsil and Their Clinical Significance [PDF]
Clinical and Experimental Otorhinolaryngology, 2011 ObjectivesTo investigate expressions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in squamous cell carcinoma of the tonsil and to correlate expression profiles with clinicopathological characteristics ...
Sei Young Lee +3 more
doaj +1 more source
, 2008 Dark Matter candidates are natural in Technicolor theories. We introduce a general framework allowing to predict signals of Technicolor Dark Matter at colliders and set constraints from earth based experiments such as CDMS and XENON.
Foadi, Roshan +2 more
core +3 more sources
Bulletin of the Korean Chemical Society, EarlyView.Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen +5 more
wiley +1 more source
Maintenance of a Protein Structure in the Dynamic Evolution of TIMPs over 600 Million Years [PDF]
, 2016 Deciphering the events leading to protein evolution represents a challenge, especially for protein families showing complex evolutionary history. Among them, TIMPs represent an ancient eukaryotic protein family widely distributed in the animal kingdom ...
COSTA, Salvatore +7 more
core +1 more source
Chemistry – A European Journal, EarlyView.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis [PDF]
, 2017 Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized ...
Brilha, Sara +5 more
core +3 more sources