Results 61 to 70 of about 25,256 (294)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Dr Sibly’s Reanimating Solar Tincture
, 2018 Using the money from Ipswich, Sibly set himself up in London for a career in quack medicine. With letters of support from brother freemasons, Sibly purchased a medical degree from King’s College in Aberdeen and began producing Dr Sibly’s Reanimating ...
Susan Mitchell Sommers
core +1 more source
Identification of effective dilutions of dental herbal remedy with antimicrobial activity
Annals of Mechnikov's Institute, 2020 Introduction.There are different ways to solve the problem of resistance of microorganisms. One of them includes an increase of the drug dose, thereby arising adverse reaction, andtheotherincludesa development of the new antimicrobial agents, where no ...
L Shulga
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
WORKING OUT OF TECHNOLOGY OF TINCTURE ARTICHOKE
, 2023 In this experimental part, we obtained conclusions on the improvement of the technological processes of the tincture obtained from the herbal of the prickly artichoke and the creation of an efficient method convenient for production ...
Abdujabborov A.A, Namozov F.Sh
core +1 more source
Applied SciencesPear buds and young leaves from three pear trees (WP, CPI, and CPII) were harvested at different developmental stages from February to May. Tinctures prepared by 14-day maceration with 70% ethanol were analysed for their phenolic profiles by LC-MS and ...
Piotr Snacki +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. The approved Russian regulations and guidelines on identification of medicinal products containing Convallaria majalis cardiac glycosides use group identification tests and thin-layer chromatography; spectrophotometry and bioassay are ...
T. A. Golomazova +5 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source