Results 91 to 100 of about 12,125 (226)

Efficacy and safety of tirofiban as an adjunctive therapy in patients with acute ST-segment elevation myocardial infarction undergoing percutaneous transluminal coronary angioplasty

National Journal of Physiology, Pharmacy and Pharmacology, 2016
Background: The introduction of stents and the use of platelet glycoprotein IIb/IIIa inhibitors, either alone or in combination with reduced-dose fibrinolytic therapy, has allowed percutaneous coronary intervention (PCI) to be performed more safely and ...
Sanjay Sharma, Seema Gupta, Sanjeev Bhat, Zahid Gillani, Dinesh Kumar, Rajesh Kumar   +5 more
doaj   +1 more source

The efficacy and safety of continuous intravenous tirofiban for acute ischemic stroke patients treated by endovascular therapy: a meta-analysis

Frontiers in Neurology
Introduction Tirofiban is a non-peptide selective glycoprotein IIb/IIIa receptor inhibitor with a short half-life. The research assesses the efficacy and safety of continuous intravenous tirofiban in patients with acute ischemic stroke (AIS) undergoing ...
Mengmeng Wang, Jing Li, Ling-Yu Zhang, Nan Li, Xuemei Li, Pengfei Wang   +5 more
semanticscholar   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Acute profound thrombocytopenia induced by tirofiban in stent assisted embolization of intracranial ruptured aneurysm-a rare case report

, 2023
Objectives: Glycoprotein (GP) IIb/IIIa receptor antagonists (Tirofiban) are often used as antiplatelet agents in patients undergoing interventional therapy due to acute coronary syndrome and cerebrovascular diseases.
Hongliang Zhong, Hongchao Yang, Tong Li, Yang Wang, Bingda Piao, He Liu   +5 more
core   +1 more source

Dual Antiplatelet Therapy in Acute Branch Atheromatous Disease (BAD)‐Related Stroke: A Multicenter Propensity‐Matched Cohort Analysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
The study aimed to compare the clinical outcomes of dual antiplatelet therapy (DAPT) vs. single antiplatelet therapy (SAPT) in branch atheromatous disease (BAD)‐related stroke. DAPT was safe but not statistically superior to SAPT for excellent functional outcome; however, its numerical trend toward benefit warrants further investigation.
Haizhou Hu, Shengde Li, Yu Zhang, Yuhui Sha, Yaping Zhou, Feng Feng, Yicheng Zhu, Lixin Zhou, Bin Peng, Jun Ni, on behalf of BAD‐study investigators   +10 more
wiley   +1 more source

In-Lab Upfront Use of Tirofiban May Reduce the Occurrence of No-Reflow During Primary Percutaneous Coronary Intervention. A Pilot Randomized Study

Arquivos Brasileiros de Cardiologia
Background: Despite successful opening of culprit coronary artery, myocardial reperfusion does not always follows primary percutaneous coronary intervention (PPCI).
Igor Matos Lago, Gustavo Caires Novaes, André Vannucchi Badran, Rafael Brolio Pavão, Ricardo Barbosa, Geraldo Luiz de Figueiredo, Moysés de Oliveira Lima Filho, Jorge Luiz Haddad, André Schmidt, José Antônio Marin Neto   +9 more
doaj   +1 more source

Efficacy and safety of tirofiban in patients with acute branch atheromatous disease-related stroke (BRANT): a protocol for a randomised controlled trial

BMJ Open
Introduction Branch atheromatous disease (BAD)-related stroke is increasingly becoming a clinical entity and prone to early neurological deterioration (END) and poor prognosis.
Sheng-De Li, Ding-Ding Zhang, Yu-Hui Sha, Yi-Cheng Zhu, Li-Xin Zhou, Bin Peng, Jun Ni   +6 more
semanticscholar   +1 more source

Association of Global Longitudinal Strain With Left Ventricular Remodeling and Left Ventricular Hypertrophy in Patients With Acute Myocardial Infarction After PCI: A Small Single‐Center Prospective Observational Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Among patients with acute myocardial infarction undergoing PCI, subsequent structural alterations of the left ventricle, including left ventricular remodeling (LVR) and left ventricular hypertrophy (LVH), may contribute to later heart failure.
Bing Wang, Hong Yao, Zhijian Zhu, Zhigang Lu, Yesheng Pan   +4 more
wiley   +1 more source

Cangrelor, Tirofiban, and Chewed or Standard Prasugrel Regimens in Patients With ST-Segment–Elevation Myocardial Infarction [PDF]

, 2020
BACKGROUND Standard administration of newer oral P2Y$_{12}$ inhibitors, including prasugrel or ticagrelor, provides suboptimal early inhibition of platelet aggregation (IPA) in patients with ST-segment-elevation myocardial infarction undergoing primary ...
Giovanni Esposito, Gianluca Campo, Gragnano, Felice, Marisa Avvedimento, Pietro Minuz, Negar Manavifar, Lukas Hunziker, Campo, Gianluca, Leonardi, Sergio, Giuseppe Gargiulo, Tebaldi, Matteo, Vranckx, Pascal, Marco Valgimigli, Manavifar, Negar, Michael Nagler, Plinio Cirillo, Avvedimento, Marisa, Sergio Leonardi, Heg, Dik, Matteo Tebaldi, Esposito, Giovanni, Windecker, Stephan, Pascal Vranckx, Gargiulo, Giuseppe, Piccolo, Raffaele, Cirillo, Plinio, Stephan Windecker, Dik Heg, Hunziker, Lukas, Nagler, Michael, Felice Gragnano, Raffaele Piccolo, Minuz, Pietro, Valgimigli, Marco, Nagler M., Gragnano F, Gargiulo G, Manavifar N, Windecker S, Vranckx P, Avvedimento M, Hunziker L., Hunziker L, Valgimigli M., Tebaldi M., Heg D, Nagler M, Leonardi S., Campo G., Leonardi S, Minuz P., Cirillo P., Manavifar N., Gargiulo G., Piccolo R, Vranckx P., Esposito G, Tebaldi M, Gragnano F., Cirillo P, Campo G, Avvedimento M., Esposito G., Piccolo R., Valgimigli M, Minuz P, Windecker S., Heg D.   +67 more
core   +2 more sources

The role of intravenous tirofiban in patients undergoing endovascular treatment for acute intracranial atherosclerotic occlusion

Journal of Stroke and Cerebrovascular Diseases
BACKGROUND AND PURPOSE: Previous reports regarding the impact of tirofiban on patients undergoing endovascular treatment for acute ischemic stroke have shown inconsistencies.
Zhiping Bu, MD, Dapeng Sun, MD, Xiaoli Zhang, PhD, Ning Ma, MD, Feng Gao, MD, Dapeng Mo, MD, Qingwei Meng, MD, Zhongrong Miao, MD   +7 more
doaj   +1 more source