Tirofiban Blocks Platelet Adhesion to Fibrin with Minimal Perturbation of GpIIb/IIIa Structure
, 2002 SummaryA biophysical approach tested the hypothesis that tirofiban, like eptifibatide, perturbs GpIIb/IIIa structure. Tirofiban bound tightly to platelet GpIIb/IIIa (EC50 ∼ 24 nmol/L) and effectively inhibited platelet aggregation (IC50 ∼ 37 nmol/L) but ...
Roy Hantgan +4 more
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Resolution of Intracoronary Thrombus with Tirofiban Infusion: A Case Report
, 2010 A 27 year-old man presented with chest pain lasting for fourteen-hour duration. The patient had electrocardiographic evidence of subacute anterior wall myocardial infarction.
Cil, Habib +5 more
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Gene mutations of platelet glycoproteins and response to tirofiban in acute coronary syndrome
, 2016 CONTEXT AND OBJECTIVES: Glycoprotein inhibitors (abciximab, eptifibatide and tirofiban) are used in patients with unstable angina and non-ST-segment elevation myocardial infarction before percutaneous coronary intervention.
Antonio de Padua Mansur (12799604) +5 more
core +1 more source
Tirofiban counteracts endothelial cell apoptosis through the VEGF/VEGFR2/pAkt axis
, 2016 Tirofiban is used in the treatment of patients with acute coronary syndrome submitted to percutaneous coronary intervention (PCI). We have, previously, shown that tirofiban stimulates VEGF expression and promotes proliferation of endothelial cells.
Biondi-Zoccai, Giuseppe +9 more
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Tirofiban-induced acute profound thrombocytopenia after primary angioplasty
, 2013 Glycoprotein IIb/IIIa inhibitors are used in the acute coronary syndromes and percutaneous coronary intervention as antiplatelet agents. However, these agents induce thrombocytopenia in approximately 1% to 5% of patients, and may lead to bleeding ...
Gür, S. +3 more
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Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis
Brain and BehaviorIntroduction Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality globally. Standard antiplatelet therapies, while partially effective, do not fully inhibit all pathways of platelet aggregation, leaving patients at risk of recurrent ...
Abdullah Bin Kamran +9 more
doaj +1 more source
Glycoprotein IIb/IIIa Inhibitors Use and Outcome after Percutaneous Coronary Intervention for Non-ST Elevation Myocardial Infarction [PDF]
, 2014 J. P. Howard +19 more
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Rescue Tirofiban for Early Neurological Deterioration After Tenecteplase in Capsular Warning Syndrome. [PDF]
J Clin NeurolCuccurullo C +3 more
europepmc +1 more source
, 2008 Objective: To evaluate the impact of long term tirofiban infusion before percutaneous coronary intervention (PCI) on the angiographic results in the setting of visible intracoronary thrombus and compare this with conventional PCI performed without ...
Balcioglu, Serhat +3 more
core
Comparison of clinical efficacy between argatroban and tirofiban in patients with atherosclerotic cerebral infarction complicated by early neurological deterioration. [PDF]
Front PharmacolWu X, Zhang R, Li S, Jiang Z, Zheng X.
europepmc +1 more source