Results 81 to 90 of about 12,125 (226)

Venom‐Derived Bioactive Peptides: From Toxins to Therapeutics

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
Venomics → Target Identification → Peptide Optimization → Therapeutic Translation Bioactive venom peptides targeting ion channels, enzymes, and receptors drive the development of next‐generation precision therapeutics. ABSTRACT Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules,
Eldho Sabu, Othman Al Musaimi
wiley   +1 more source

Tirofiban combined with Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY): protocol for a multicentre, randomised controlled trial

Stroke and Vascular Neurology
Background Perforating artery territorial infarction (PAI) caused by branch atheromatous disease (BAD) is prone to recurrence and early progression without an effective and well-documented antiplatelet treatment regimen.
Liping Liu, Yongjun Wang, Yilong Wang, Xingquan Zhao, Xiaoling Liao, Weiqi Chen, Yuesong Pan, Hui Qu, Shuo Feng, Yicong Wang   +9 more
doaj   +1 more source

Efficacy of simultaneous infusion of tirofiban with intravenous thrombolysis in patients with acute anterior choroidal or paramedian pontine infarction: TITACIPPI study

Frontiers in Neurology
Background and purposeIntravenous thrombolysis combined with tirofiban (IVT plus tirofiban) has been reported to be more effective than IVT alone in preventing early neurological deterioration (END) and improving 3-month functional outcomes in patients ...
Moussa Toudou-Daouda, Moussa Toudou-Daouda, Djibril Soumah, Leila Bentamra, Nana-Rahamatou Aminou-Tassiou, Mohamed Baby, Yann Lhermitte, Tony Altarcha, Manvel Aghasaryan, Didier Smadja, Didier Smadja, Didier Smadja, Nicolas Chausson, Nicolas Chausson, Nicolas Chausson   +14 more
doaj   +1 more source

Bridging Therapy Versus Intravenous Thrombolysis Alone in Patients With Medium Vessel Occlusion Stroke: A Single‐Center Cohort Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background To compare the outcomes of bridging therapy versus intravenous thrombolysis (IVT) alone in patients with medium vessel occlusion (MeVO). Methods Consecutive MeVO patients between January 2019 and December 2024 were retrospectively included and classified into IVT alone or bridging therapy groups.
Di Hu, Mo Yang, Zhenghua Gu, Jie Fan, Lizhi Yu, Chengcai Xia, Qingguo Ren   +6 more
wiley   +1 more source

Tirofiban-Induced Thrombocytopenia Occurring with Crohn’s Disease

, 2016
A 69-year-old man, with severe refractory Crohn’s disease, presented with acute coronary syndrome that required angioplasty. He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a ...
Fady El Karak, Toni Ibrahim, Assem Araji, Elie El Rassy   +3 more
core   +1 more source

SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE

Российский кардиологический журнал, 2014
Aim. This work aims to study the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS).Material and methods. 120 AIS patients were included in this study.
Yan-Jun Zhang, Qing Liu, Qin Zhan, Qiong Li   +3 more
doaj   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, Volume 13, Issue 7, Page 1357-1369, July 2026.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Data_Sheet_1_The impact of intraarterial, intravenous, and combined tirofiban on endovascular treatment for acute intracranial atherosclerotic occlusion.docx

Background and purposeAdjunctive tirofiban administration in patients undergoing endovascular treatment (EVT) for acute large vessel occlusion (LVO) has been investigated in several studies. However, the findings are conflict. This study aimed to compare
Xiaoqing Li (186909), Zhiping Bu (17953769), Zhongrong Miao (562624), Xiaochuan Huo (2141878), Dapeng Mo (619835), Bo Wang (86769), Gaoting Ma (6405032), Gang Luo (425896), Xu Tong (8099873), Feng Gao (3548), Baixue Jia (6376634), Ning Ma (155058), Anxin Wang (101844), Xuan Sun (619836), Ligang Song (619838), Yiming Deng (2814844), Deguo Su (3774229), Dapeng Sun (319496)   +17 more
core   +1 more source

Tirofiban-induced acute profound thrombocytopenia after primary angioplasty

, 2013
Glycoprotein IIb/IIIa inhibitors are used in the acute coronary syndromes and percutaneous coronary intervention as antiplatelet agents. However, these agents induce thrombocytopenia in approximately 1% to 5% of patients, and may lead to bleeding ...
Gür, S., Taşköylü, Ö., Sari, Hakan İsmail, Dursunoğlu, Dursun   +3 more
core   +1 more source

Severe thrombocytopenia induced by tirofiban after percutaneous coronary intervention: a case report

, 2023
Background Tirofiban is a nonpeptide glycoprotein IIb/IIIa receptor antagonist used widely in patients subjected to percutaneous coronary intervention.
Ze-Mu Wang, Bin Wang, Qin Shen, Lian-Sheng Wang, Bei Chen, Dian-Fu Li, Ya-Fei Li   +6 more
core   +1 more source