Results 61 to 70 of about 12,125 (226)

Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model

Nature Communications
Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role for platelet αIIbβ3 in VT is
Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi-Xian Deng, Hyun Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes van Agthoven, Mark Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout   +14 more
doaj   +1 more source

Efeito protetor de antagonista das gliproteínas IIb/IIa nas alterações hepáticas e pulmonares secundárias à isquemia e reperfusão do fígado em ratos Protective effects of an inhibitor of glycoprotein IIb/IIIa in the hepatic and pulmonary disturbances secondary to ischemia and reperfusion injury of rat’s liver

Arquivos de Gastroenterologia, 2007
RACIONAL: A lesão de isquemia e reperfusão hepática é um evento comum e responsável por considerável morbidade e mortalidade. OBJETIVO: Avaliar efeitos de inibidor da glicoproteína IIb/IIIa, cloridrato de tirofiban, nas alterações hepáticas e pulmonares ...
Leonardo F. Canedo, Marcel Autran C. Machado, Ana M. M. Coelho, Sandra N. Sampietre, Telesforo Bachella, Marcel C. C. Machado   +5 more
doaj   +1 more source

Use of Intracoronary Pressure Wire Assessment and Association With Outcomes: Insights From the British Cardiovascular Intervention Society National Database

Catheterization and Cardiovascular Interventions, Volume 108, Issue 4, Page 1743-1753, October 1, 2026.
ABSTRACT Background Despite recommendations in international guidelines, Intracoronary pressure wire assessment (PWA) utilization remains limited in clinical practice. This study aims to describe (i) trends of PWA during Percutaneous coronary interventional (PCI), (ii) factors that predict its application, and (iii) association with in‐hospital ...
Hussein Bashar, Muhammad Rashid, Mamas A. Mamas, Nick Curzen   +3 more
wiley   +1 more source

Case report: reuse of tirofiban leads to very severe thrombocytopenia

Frontiers in Cardiovascular Medicine, 2023
BackgroundTelofiban is a class of small molecule non-peptide tyrosine derivatives containing RGD sequences. It is the only platelet surface glycoprotein (GP) IIb/IIIa receptor antagonist (GPI) currently marketed in China.
Yuqing Li, Jiuchun Qiu, Yi Gao, Guangping Li   +3 more
doaj   +1 more source

Tirofiban-induced thrombocytopenia

Annals medicus, 2023
Tirofiban is a small non-peptide ligand-mimetic Glycoprotein (GP) IIb/IIIa inhibitor which can reversibly bind to the arginine-glycine-aspartic acid (RGD) recognition site of GP IIb/IIIa to prevent platelet aggregation.
Jun Wang, Dongna Zou
semanticscholar   +1 more source

Association between tirofiban monotherapy and efficacy and safety in acute ischemic stroke

BMC Neurology, 2021
Background Studies have suggested that glycoprotein IIb/IIIa antagonists such as tirofiban are beneficial for patients with acute coronary syndromes.
Chunrong Tao, Yuyou Zhu, Chao Zhang, Jianlong Song, Tianlong Liu, Xiaodong Yuan, Wenwu Luo, Changchun Chen, Dezhi Liu, Yuanyuan Zhu, Jie Liu, Wei Hu   +11 more
doaj   +1 more source

Safety and Efficacy of Tirofiban During Intravenous Thrombolysis Bridging to Mechanical Thrombectomy for Acute Ischemic Stroke Patients: A Meta-Analysis

Frontiers in Neurology, 2022
IntroductionThe safety and efficacy of tirofiban in intravenous thrombolysis (IVT) bridging to mechanical thrombectomy in patients with acute ischemic stroke (AIS) is unknown.
Wei Li, Wei Li, Wei Li, Guohui Lin, Zaixing Xiao, Zaixing Xiao, Yichuan Zhang, Yichuan Zhang, Bin Li, Bin Li, Yu Zhou, Yu Zhou, Erqing Chai, Erqing Chai   +13 more
doaj   +1 more source

Evaluation of safety and efficacy of Tirofiban injection for treating acute ischemic stroke beyond standard time window

Scientific Reports
To evaluate the safety and efficacy of tirofiban in the treatment of acute ischemic stroke (AIS). Clinical data of 152 AIS patients with small vessel occlusion admitted in 2023 were retrospectively analyzed.
Qian Yang, Qiao-Feng He, Xin-Fa Mao, Weibing Fan, Xin Luo   +4 more
semanticscholar   +1 more source

Safety and efficacy of tirofiban in the management of stroke: A systematic review and meta-analysis of randomized controlled trials.

Clinical neurology and neurosurgery (Dutch-Flemish ed. Print), 2023
BACKGROUND About 30 % of stroke patients have experienced unsuccessful reperfusion following endovascular therapy. Mechanical thrombectomy instruments may contribute to this by stimulating platelet aggregation.
M. M. Al-Salihi, Ali Ayyad, M. S. Al-Jebur, Yezan Al-Salihi, Ram K. Saha, R. Morsi, T. Kasshout, S. Al Kasab, A. Spiotta   +8 more
semanticscholar   +1 more source

Forest plot of TVR, death and reinfarction in ACS patients treated with IC vs. IV administration of tirofiban.

, 2015
(A). Forest plot for TVR based on a fixed-effects model in ACS patients treated with IC vs. IV administration of tirofiban. (B). Forest plot for death based on a fixed-effects model in ACS patients treated with IC vs. IV administration of tirofiban. (C).
Peng Liu (120506), Xiuying Tang (5663965), Quanmin Jing (753445), Yingfeng Liu (753446), Runjun Li (753444)   +4 more
core   +1 more source