Results 51 to 60 of about 10,449 (205)

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

C-reactive protein binds to alphaIIbbeta3. [PDF]

, 2008
C-reactive protein binds to ...
Brennan, Marian P, Chubb, Anthony J, Cox, Dermot, Grennan, S, Moriarty, Roisin D   +4 more
core  

Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model

Nature Communications
Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role for platelet αIIbβ3 in VT is
Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi-Xian Deng, Hyun Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes van Agthoven, Mark Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout   +14 more
doaj   +1 more source

There is no difference in safety and efficacy mechanical thrombectomy alone or mechanical thrombectomy with tirofiban for patients undergoing treatment of large vessel occlusion and underlying intracranial atherosclerosis

Interdisciplinary Neurosurgery, 2022
Background: Mechanical thrombectomy (MT) is a widely proven method to treat acute ischemic stroke (AIS) during mechanical thrombectomy and acute stenting and angioplasty is a topic discussed till this day regarding safety and efficacy.
Hari Movva, Rani Rabah, Wondwossen Tekle, Laurie Preston, Hari Kotta, Ameer E Hassan   +5 more
doaj   +1 more source

Identification of Key Genes and Pathways Associated With Gender Differences in Pulmonary Arterial Hypertension Based on Bioinformatic Approaches

BioMed Research International, Volume 2026, Issue 1, 2026.
Pulmonary arterial hypertension (PAH) is a complex disease with multiple contributing factors. Epidemiological data showed that women are more susceptible to PAH, but they tend to have better right ventricular (RV) function and prognosis compared to men. The mechanisms behind these gender differences are not well understood.
Mohammad Panahi, Reyhaneh Kalhor, Mohammad-Hossein Mokhtarian, Fatemeh Javaheri Tehrani, Zinat Shams, Hourieh Kalhor, Hannah Wesley   +6 more
wiley   +1 more source

Aspirin plus tirofiban inhibit the thrombosis induced by Russell’s viper venom [PDF]

, 2016
BACKGROUND: Thrombosis and coagulopathy are the commonest hematological manifestations of envenomation of Russell’s viper venom (RVV). Factor X is activated by a factor X-activating enzyme from Russell’s viper venom (RVV-X) to start the coagulation ...
Li-Kuang Chen, Ping-Tse Chou, Ren-Chieh Wu   +2 more
core   +1 more source

Subtyping treatment response of tirofiban in acute ischemic stroke based on neuroimaging features

Clinical and Translational Science
In a previously published clinical trial, we demonstrated that tirofiban was effective and safe in acute ischemic stroke (AIS) patients who did not undergo early recanalization treatments.
Bin Han, Xu Man, Jian Ding, Yuzhu Li, Xintao Tian, Xuelian Zhu, Jiang Yu, Jinping Sun   +7 more
doaj   +1 more source

Safety and Efficacy of Ultra‐Early Tirofiban Treatment Following Alteplase in Patients With Noncardioembolic Acute Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Secondary platelet activation peaks ≈2 hours after intravenous thrombolysis with alteplase. This study evaluated the safety and efficacy of ultra‐early tirofiban administration and compared different tirofiban regimens following intravenous ...
Qing Zhao, Yi Yang, Wangsheng Jin, Huaqiao Chi, De Yang, Shengli Chen, Chengchun Liu, Ya Wu, Xiaoshu Li, Zhiqiang Sun, Wenjun Han, Zihao Wang, Rongchang Zhao, Yanjiang Wang, Wei Li, Meng Zhang   +15 more
doaj   +1 more source

Tirofiban‐Associated Profound Thrombocytopenia in a Patient With Glucose‐6‐Phosphate Dehydrogenase Deficiency Undergoing Primary Percutaneous Coronary Intervention: A Case Report

Case Reports in Cardiology, Volume 2026, Issue 1, 2026.
Background Profound thrombocytopenia after tirofiban exposure during primary percutaneous coronary intervention (PCI) is rare but clinically important. Causal attribution may be challenging when unfractionated heparin is coadministered, and the relevance of glucose‐6‐phosphate dehydrogenase (G6PD) deficiency remains uncertain.
Chuanwei Zhao, Yansi Wang, Shizhen Gao, Wei Meng, Yane Yang, Wenjie Tan, Satabdi Datta Choudhury   +6 more
wiley   +1 more source

A mixed treatment comparison for short- and long-term outcomes of bare metal and drug eluting coronary stents [PDF]

, 2016
Background The increasing use of drug eluting stents in interventional cardiology calls for assessment of their efficacy and safety, both among drug eluting and bare-metal stents, in the context of rational decision making.
Dias, Sofia, Petrou, Panagiotis
core   +2 more sources