Results 71 to 80 of about 7,611 (182)

Efficacy and safety of tirofiban as an adjunctive therapy in patients with acute ST-segment elevation myocardial infarction undergoing percutaneous transluminal coronary angioplasty

National Journal of Physiology, Pharmacy and Pharmacology, 2016
Background: The introduction of stents and the use of platelet glycoprotein IIb/IIIa inhibitors, either alone or in combination with reduced-dose fibrinolytic therapy, has allowed percutaneous coronary intervention (PCI) to be performed more safely and ...
Sanjay Sharma, Seema Gupta, Sanjeev Bhat, Zahid Gillani, Dinesh Kumar, Rajesh Kumar   +5 more
doaj   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Randomized Comparison of Upstream Tirofiban Versus Downstream High Bolus Dose Tirofiban or Abciximab on Tissue-Level Perfusion and Troponin Release in High-Risk Acute Coronary Syndromes Treated With Percutaneous Coronary Interventions The EVEREST Trial [PDF]

, 2006
ObjectivesWe aimed to compare the effects of upstream tirofiban versus downstream high-dose bolus (HDB) tirofiban and abciximab on tissue level perfusion and troponin I release in high-risk non–ST-segment elevation acute coronary syndrome (ACS) patients ...
Burali, Antonio, Tarducci, Roberto, Ducci, Kenneth, Baldassarre, Silvia, Falsini, Giovanni, Angioli, Paolo, Taddei, Tamara, Liistro, Francesco, Cosmi, Franco, Bolognese, Leonardo   +9 more
core   +1 more source

Standardizing the Clinical Approach to Cancer Therapy‐Related Cardiac Dysfunction: Applying Cardio‐Oncology Guidelines as a Practical Tool for Hematology and Oncology Providers

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Introduction and Methods Cancer therapy–related cardiac dysfunction (CTRCD) is a well established and potentially life‐threatening complication of contemporary oncologic treatment. Although comprehensive cardio‐oncology guidelines have been developed, their integration into routine hematology and oncology practice remains inconsistent.
Abdelrahman Ali, Suparna C. Clasen, Anne Blaes, Stephen Casselli, Anita Deswal, Susan Halli Demeter, Gregory Durm, Anecita Fadol, Alessandra Ferrajoli, Michael G. Fradley, Joerg Herrmann, Borja Ibanez, Sue Koob, Bogda Koczwara, Kasey J. Leger, Jennifer E. Liu, Teresa López‐Fernández, Alexander R. Lyon, N. G. Choon Ta, John Teerlink, Eric H. Yang, Susan Dent, Daniel Lenihan   +22 more
wiley   +1 more source

The role of intravenous tirofiban in patients undergoing endovascular treatment for acute intracranial atherosclerotic occlusion

Journal of Stroke and Cerebrovascular Diseases
BACKGROUND AND PURPOSE: Previous reports regarding the impact of tirofiban on patients undergoing endovascular treatment for acute ischemic stroke have shown inconsistencies.
Zhiping Bu, MD, Dapeng Sun, MD, Xiaoli Zhang, PhD, Ning Ma, MD, Feng Gao, MD, Dapeng Mo, MD, Qingwei Meng, MD, Zhongrong Miao, MD   +7 more
doaj   +1 more source

Association of the Triglyceride–Glucose (TyG) Index and TyG‐BMI With 1‐Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TyG and TyG‐BMI independently predicted unfavorable functional outcome and 1‐year mortality after endovascular treatment for acute basilar artery occlusion. Higher values were associated with worse prognosis, with TyG‐BMI showing a sex‐specific effect on mortality, confined to men.
Qiuting Wang, Haodong Li, Yuxin Chen, Na Liu, Lu Yang, Chuanjie Wu, Wenbo Zhao, Longfei Wu, Liqun Jiao, Sijie Li, Qingfeng Ma, Xunming Ji, Chuanhui Li   +12 more
wiley   +1 more source

In-Lab Upfront Use of Tirofiban May Reduce the Occurrence of No-Reflow During Primary Percutaneous Coronary Intervention. A Pilot Randomized Study

Arquivos Brasileiros de Cardiologia
Background: Despite successful opening of culprit coronary artery, myocardial reperfusion does not always follows primary percutaneous coronary intervention (PPCI).
Igor Matos Lago, Gustavo Caires Novaes, André Vannucchi Badran, Rafael Brolio Pavão, Ricardo Barbosa, Geraldo Luiz de Figueiredo, Moysés de Oliveira Lima Filho, Jorge Luiz Haddad, André Schmidt, José Antônio Marin Neto   +9 more
doaj   +1 more source

Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms

Stroke and Vascular Neurology, 2019
Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling (SAC) and flow diverters. Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy (DAPT) are required to prevent thromboembolic ...
David M Hasan, Santiago Ortega-Gutierrez, Edgar A Samaniego, Pascal Jabbour, Jorge A Roa, Daichi Nakagawa, Mario Zanaty, Emilee Gibson   +7 more
doaj   +1 more source

Tirofiban versus aspirin to prevent in-stent thrombosis after emergent carotid artery stenting in acute ischemic stroke

[Background] Several antithrombotic treatments during emergent carotid artery stenting (eCAS) have been proposed, but an appropriate protocol to balance risk–benefit is not well known.[Objective] To investigate the efficacy and safety of tirofiban ...
Pardo‐Galiana, Blanca, Albóniga-Chindurza, Asier de, Ainz-Gómez, Leire, Villagran, Diego, Luque-Ambrosiani, Antonio, Cabezas Rodríguez, Juan Antonio, Medina-Rodríguez, Manuel, Aguilar-Pérez, Marta, Zapata‐Arriaza, Elena, Moniche, Francisco, Zamora, Aynara, González, Alejandro, Baena Palomino, Pablo   +12 more
core   +1 more source

Table_1_Platelet Function and Risk of Bleeding in Patients With Acute Coronary Syndrome Following Tirofiban Infusion.xls

, 2019
Aim: To assess platelet (PLT) function and bleeding risks in patients with acute coronary syndrome after tirofiban infusion.Methods: Patients diagnosed with acute coronary syndrome from May 2016 to February 2018 in the Department of Cardiac Intensive ...
Qiuyi Ji (7479773), Qianzhou Lv (6247604), Zi Wang (324031), Qibing Wang (3320352), Xiaoye Li (3797077), Shuning Zhang (2899217), Xiaoyu Li (154408)   +6 more
core   +1 more source