Results 61 to 70 of about 12,770 (237)

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper

Allergy, Volume 80, Issue 11, Page 2973-2987, November 2025.
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Gabriele Cortellini, Alla Nakonechna, Annick Barbaud, Sevim Bavbek, Gianfranco Calogiuri, Inmaculada Doña, Violeta Kvedariene, Jose Julio Laguna Martinez, Serena Liberati, Mauro Pagani, Antonino Romano   +10 more
wiley   +1 more source

Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model

Nature Communications
Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role for platelet αIIbβ3 in VT is
Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi-Xian Deng, Hyun Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes van Agthoven, Mark Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout   +14 more
doaj   +1 more source

Adjunct Intraarterial or Intravenous Tirofiban Versus No Tirofiban After Successful Recanalization of Basilar Artery Occlusion Stroke: The BASILAR Registry

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Approximately half of patients who achieve successful reperfusion do not achieve functional independence. The present study sought to investigate the clinical outcomes and safety of intraarterial or intravenous tirofiban as adjunct therapy in ...
Huagang Li, Dongsheng Ju, Zhaojun Tao, Jiayin Wang, Thanh N. Nguyen, Jeffrey L. Saver, Raul G. Nogueira, Chang Liu, Qingwu Yang, Zhongming Qiu, Congguo Yin, Dong Sun, Shudong Liu   +12 more
doaj   +1 more source

Development and validation of reverse phase high performance liquid chromatographic method for determination of Tirofiban in serum [PDF]

, 2014
А specific, sensitive and rapid RP-HPLC method has been developed for the determination of Tirofiban in serum. The chromatographic separation was realized using reverse phase LiChrospher® 100 RP-18 column (4.0 mm × 250 mm, 5 μm) and mobile phase ...
Arsova-Sarafinovska, Zorica, Darkovska-Serafimovska, Marija, Djorgoski, Icko, Janevik-Ivanovska, Emilija, Ugresic, Nenad   +4 more
core  

Subtyping treatment response of tirofiban in acute ischemic stroke based on neuroimaging features

Clinical and Translational Science
In a previously published clinical trial, we demonstrated that tirofiban was effective and safe in acute ischemic stroke (AIS) patients who did not undergo early recanalization treatments.
Bin Han, Xu Man, Jian Ding, Yuzhu Li, Xintao Tian, Xuelian Zhu, Jiang Yu, Jinping Sun   +7 more
doaj   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, Volume 37, Issue 40, October 9, 2025.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

Safety and Efficacy of Tirofiban During Mechanical Thrombectomy for Stroke Patients with Preceding Intravenous Thrombolysis

Clinical Interventions in Aging, 2020
Xiaochuan Huo,1,2,* Ming Yang,1,2,* Ning Ma,1,2 Feng Gao,1,2 Dapeng Mo,1,2 Xiaoqing Li,1,2 Anxin Wang,2,3 Yongjun Wang,2,3 Zhongrong Miao1,2 1Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing ...
Huo X, Yang M, Ma N, Gao F, Mo D, Li X, Wang A, Wang Y, Miao Z   +8 more
doaj  

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

Journal of Applied Toxicology, Volume 45, Issue 10, Page 2055-2067, October 2025.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor, Beric Muller, Lesetja R. Motadi, Lizelle A. Piater   +3 more
wiley   +1 more source

C-reactive protein binds to alphaIIbbeta3. [PDF]

, 2008
C-reactive protein binds to ...
Brennan, Marian P, Chubb, Anthony J, Cox, Dermot, Grennan, S, Moriarty, Roisin D   +4 more
core  

A Critical Review on BH3 Mimetic Drugs and the Treatment of Cancer‐Associated Thrombosis (CAT): A Proposed Design for a Drug Delivery System Capable of Simultaneously Targeting Tumor Cells and Activated Platelets

Cancer Medicine, Volume 14, Issue 18, September 2025.
Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh, Nazanin Heidari, Jalal Naghinezhad, Alireza Ghasemzadeh, Ehteramolsadat Hosseini   +4 more
wiley   +1 more source