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Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip
Trends in Biotechnology, 2021Strategies to regenerate cardiac tissue postinjury are limited and heart transplantation remains the only 'cure' for a failing heart. Extracellular vesicles (EVs), membrane-bound cell secretions important in intercellular signaling, have been shown to play a crucial role in regulating heart function.
Yimu Zhao, Bohao Liu, Karl T Wagner
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·Reconstituting Organ-Level Periodontal Soft Tissue on a Chip
2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021Periodontitis, as the most common chronic inflammatory disease which causes oral dysfunction, is also closely related to atherosclerosis, Alzheimer's disease, ischemic stroke and other small vessel brain diseases. Now, we describe a biomimetic microsystem that reconstitutes the critical functional epithelium-capillary interface of the human Periodontal
Laidi Jin +4 more
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Blood brain barrier: A tissue engineered microfluidic chip
Journal of Neuroscience Methods, 2020With the increasing concern of neurological diseases, the improvised therapy for neurodegenerative disorders such as Alzheimer's disease is crucial. Yet, the efficacious delivery of drug across blood-brain barrier (BBB) remains a formidable challenge. BBB acts as a gate keeper to prevent the ingress of harmful foreign agents into the brain.
Musafargani, Sikkandhar +6 more
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Biofabrication, 2022
Abstract Over the past years, 3D in vitro models have been widely employed in the regenerative medicine field. Among them, organ-on-a-chip technology has the potential to elucidate cellular mechanism exploiting multichannel microfluidic devices to establish 3D co-culture ...
D Petta +6 more
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Abstract Over the past years, 3D in vitro models have been widely employed in the regenerative medicine field. Among them, organ-on-a-chip technology has the potential to elucidate cellular mechanism exploiting multichannel microfluidic devices to establish 3D co-culture ...
D Petta +6 more
openaire +4 more sources
Molecular dynamics of orientation controlled muscle tissue on a chip
2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS), 2015In this paper, we clarify the relationship between myoblast orientation and myogenesis by pattering myoblasts and analyzing gene expression of self-assembling muscle tissue over time. Previous studies have shown that it is possible to pattern muscle cells by culturing cells on chemically or physically patterned surfaces.
Yuki Okino +2 more
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Comprehensive analysis of DNA-methylation in mammalian tissues using MeDIP-chip
Methods, 2011Genome-wide mapping of epigenetic changes is essential for understanding the mechanisms involved in gene regulation during cell differentiation and embryonic development. DNA-methylation is one of these key epigenetic marks that is directly linked to gene expression is.
Nina, Pälmke +2 more
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Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip
Biomaterials, 2020Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the leading cause of mortality worldwide. Considerable research into human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has highlighted their immense potential in the development of in vitro human cardiac tissues for broad mechanistic, therapeutic ...
Jaimeson, Veldhuizen +4 more
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