Results 1 to 10 of about 132,211,819 (268)

Advances in cardiac tissue engineering and heart-on-a-chip [PDF]

Journal of Biomedical Materials Research - Part A, 2023
AbstractRecent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled.
Yimu Zhao, Erika Yan Wang, Shira Landau
exaly   +4 more sources

Hydrogel-Integrated Heart-on-a-Chip Platform for Assessment of Myocardial Ischemia Markers [PDF]

ACS Omega
Organ-on-a-chip platform scans offer a controllable environment and a physiological similarity to mimic human pathophysiology. In this study, a single-channel PDMS microchip was fabricated, characterized, and optimized to obtain a heart-on-a-chip platform, which is integrated with a hydrogel scaffold suitable for cardiomyocyte growth inside its channel.
Berna Ates, Tolga Eroglu, Seray Sahsuvar, Ceyhun Ekrem Kirimli, Ozgur Kocaturk, Sahin Senay, Ozgul Gok   +6 more
doaj   +5 more sources

Automated fabrication of a scalable heart-on-a-chip device by 3D printing of thermoplastic elastomer nanocomposite and hot embossing [PDF]

Bioactive Materials
Ruikang Xue, Sarah Cartmell, Yimu Zhao
exaly   +2 more sources

Study of Stem Cells Influence on Cardiac Cells Cultured with a Cyanide-P-Trifluoromethoxyphenylhydrazone in Organ-on-a-Chip System

Biosensors, 2021
Regenerative medicine and stem cells could prove to be an effective solution to the problem of treating heart failure caused by ischemic heart disease. However, further studies on the understanding of the processes which occur during the regeneration of ...
Anna Kobuszewska, Dominik Kolodziejek, Michal Wojasinski, Tomasz Ciach, Zbigniew Brzozka, Elzbieta Jastrzebska   +5 more
doaj   +1 more source

Breakthroughs and Applications of Organ-on-a-Chip Technology

Cells, 2022
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous advantages of OOAC over conventional systems make it highly popular. The chip is
Mufeeda C. Koyilot, Priyadarshini Natarajan, Clayton R. Hunt, Sonish Sivarajkumar, Romy Roy, Shreeram Joglekar, Shruti Pandita, Carl W. Tong, Shamsudheen Marakkar, Lakshminarayanan Subramanian, Shalini S. Yadav, Anoop V. Cherian, Tej K. Pandita, Khader Shameer, Kamlesh K. Yadav   +14 more
doaj   +1 more source

Timely delivery of cardiac mmRNAs in microfluidics enhances cardiogenic programming of human pluripotent stem cells

Frontiers in Bioengineering and Biotechnology, 2022
In the last two decades lab-on-chip models, specifically heart-on-chip, have been developed as promising technologies for recapitulating physiological environments suitable for studies of drug and environmental effects on either human physiological or ...
Anna Contato, Anna Contato, Onelia Gagliano, Onelia Gagliano, Michael Magnussen, Monica Giomo, Nicola Elvassore, Nicola Elvassore, Nicola Elvassore   +8 more
doaj   +1 more source

Designing Biomaterial Platforms for Cardiac Tissue and Disease Modeling

Advanced NanoBiomed Research, 2021
Heart disease is one of the leading causes of death in the world. There is a growing demand for in vitro cardiac models that can recapitulate the complex physiology of the cardiac tissue.
Andrew House, Iren Atalla, Eun Jung Lee, Murat Guvendiren   +3 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist's Point of View

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow abnormality induced by age‐related DNA mutations, which give rise to proinflammatory immune cells. These immune cells exacerbate atherosclerotic cardiovascular disease and may
Maurits A. Sikking, Sophie L. V. M. Stroeks, Olivia J. Waring, Michiel T. H. M. Henkens, Niels P. Riksen, Alexander Hoischen, Stephane R. B. Heymans, Job A. J. Verdonschot   +7 more
doaj   +1 more source

Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Risk in Patients with Chronic Kidney Disease without Previous Cardiac Pathology

Life, 2023
Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the clonal expansion of hematopoietic stem cells carrying certain genes associated with an increased risk of hematological malignancies.
Maria Kislikova, Maria Ana Batlle Lopez, Francisco Javier Freire Salinas, José Antonio Parra Blanco, Maria Pilar García-Berbel Molina, Alejandro Aguilera Fernandez, Vicente Celestino Piñera Haces, Maria Teresa García Unzueta, Adalberto Benito Hernández, Juan Carlos Ruiz San Millan, Emilio Rodrigo Calabia   +10 more
doaj   +1 more source

Journey of organ on a chip technology and its role in future healthcare scenario

Applied Surface Science Advances, 2022
Organ on a chip refers to microengineered biomimetic system which reflects structural and functional characteristics of human tissue. It involves biomaterial technology, cell biology and engineering combined together in a miniaturized platform.
Deepanmol Singh, Ashish Mathur, Smriti Arora, Souradeep Roy, Neeraj Mahindroo   +4 more
doaj   +1 more source