Results 21 to 30 of about 132,211,819 (268)

Recent Developments, Applications, and Future Prospects of Advanced Hearts-on-a-Chip [PDF]

Micromachines
Heart-on-a-chip (HoC) platforms represent a cutting-edge convergence of microfluidics and cellular biology, designed to imitate the complex physiological, electrical, and mechanical environments of a human heart.
Aerin Kang, Hayun Lee, Gurnho Park, Taehong Kim, Hyoju Kim, Timothy Park, Sydney Staley, Miriam Kang, Youngbok (Abraham) Kang   +8 more
doaj   +2 more sources

Heart-on-a-Chip: Leveraging Technology for Sickle Cell Disease. [PDF]

JACC Adv, 2023
Folh J, Horton RE, Sulague RM, Kpodonu J.   +3 more
europepmc   +3 more sources

Fabrication and Biomedical Applications of Heart-on-a-chip. [PDF]

Int J Bioprint, 2021
Heart diseases have become the main killer threatening human health, and various methods have been developed to study heart disease. Among them, heart-on-a-chip has emerged in recent years as a method for constructing disease (or normal) models in vitro and is considered as a promising tool to study heart diseases.
Yang Q, Xiao Z, Lv X, Zhang T, Liu H.
europepmc   +3 more sources

Heart-on-a-Chip at the final frontier. [PDF]

Proc Natl Acad Sci U S A
McCain ML.
europepmc   +3 more sources

Biomimetic heart platforms for drug development [PDF]

Organoid, 2022
New drug development is currently very expensive and time-consuming. In addition, some drugs that are approved after animal and clinical trials have their approval revoked because of adverse effects.
Sungwoo Cho, Sungho Ko
doaj   +1 more source

Flexible 3D printed microwires and 3D microelectrodes for heart-on-a-chip engineering. [PDF]

Biofabrication, 2023
Abstract We developed a heart-on-a-chip platform that integrates highly flexible, vertical, 3D micropillar electrodes for electrophysiological recording and elastic microwires for the tissue’s contractile force assessment. The high aspect ratio microelectrodes were 3D-printed into the device using a conductive polymer, poly(3,4 ...
Wu Q, Zhang P, O'Leary G, Zhao Y, Xu Y, Rafatian N, Okhovatian S, Landau S, Valiante TA, Travas-Sejdic J, Radisic M.   +10 more
europepmc   +3 more sources

Integrating biological vasculature into a multi-organ-chip microsystem [PDF]

, 2022
S.3588-3598A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale.
Lindner, G., Sonntag, F., Menzel, U., Marx, U., Groth, B., Horland, R., Lauster, R., Hoffmann, S., Walles, Heike, Lorenz, A., Schimek, K., Busek, M., Brincker, S.   +12 more
core   +2 more sources

A global wire planning scheme for Network-on-Chip. [PDF]

, 2003
As technology scales down, the interconnect for on-chip global communication becomes the delay bottleneck. In order to provide well-controlled global wire delay and efficient global communication, a packet switched Network-on-Chip (NoC) architecture was ...
J. Liu, Tenhunen, Hannu, H Tenhunen, Liu, Jian, Zheng, Li-Rong, Pamunuwa, Dinesh, Liu, J., Zheng, L-R, Pamunuwa, Dinesh B., L-r Zheng, D. Pamunuwa, L.-R. Zheng, H. Tenhunen   +12 more
core   +4 more sources

Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform. [PDF]

Proc Natl Acad Sci U S A
With current plans for manned missions to Mars and beyond, the need to better understand, prevent, and counteract the harmful effects of long-duration spaceflight on the body is becoming increasingly important. In this study, an automated heart-on-a-chip platform was flown to the International Space Station on a 1-mo mission during which contractile ...
Mair DB, Tsui JH, Higashi T, Koenig P, Dong Z, Chen JF, Meir JU, Smith AST, Lee PHU, Ahn EH, Countryman S, Sniadecki NJ, Kim DH.   +12 more
europepmc   +3 more sources

An Integrated Liver- and Heart-On-A-Chip Platform [PDF]

Biophysical Journal, 2014
Engineering microfluidic devices to mimic human organs' microenvironments addresses many of the challenges of in vivo models, such as the lack of controllability and repeatability, and conventional static in vitro models, including deficiency in mimicking organ complexities.
Salmanzadeh, Alireza, Lee, Luke P.
openaire   +1 more source