Electroconductive and Anisotropic Structural Color Hydrogels for Visual Heart‐on‐a‐Chip Construction [PDF]
Advanced Science, 2022 Heart‐on‐a‐chip plays an important role in revealing the biological mechanism and developing new drugs for cardiomyopathy. Tremendous efforts have been devoted to developing heart‐on‐a‐chip systems featuring simplified fabrication, accurate imitation and
Lingyu Sun +3 more
doaj +5 more sources
Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies [PDF]
Materials Today BioRecent advances in heart-on-a-chip systems hold great promise to facilitate cardiac physiological, pathological, and pharmacological studies. This review focuses on the development of heart-on-a-chip systems with tissue-specific functionalities.
Bingsong Gu +9 more
doaj +6 more sources
Human heart-on-a-chip microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes [PDF]
Scientific ReportsIn recent years, research on organ-on-a-chip technology has been flourishing, particularly for drug screening and disease model development. Fibroblasts and vascular endothelial cells engage in crosstalk through paracrine signaling and direct cell–cell ...
Yun Liu +7 more
doaj +3 more sources
Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling [PDF]
Journal of Translational MedicineHeart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately ...
Beiqin Liu +6 more
doaj +4 more sources
Micromachines, 2016 Drug cardiac safety assessments play a significant role in drug discovery. Drug-induced cardiotoxicity is one of the main reasons for drug attrition, even when antiarrhythmic drugs can otherwise effectively treat the arrhythmias.
Xi Zhang +3 more
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Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors [PDF]
Microsystems & NanoengineeringHeart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for the development of engineered cardiac tissue, facilitating high-throughput testing in drug development and clinical treatment. HoC is primarily used to create a biomimetic
Feng Xu +7 more
doaj +4 more sources
Towards chamber specific heart-on-a-chip for drug testing applications [PDF]
Advanced Drug Delivery Reviews, 2020 Modeling of human organs has long been a task for scientists in order to lower the costs of therapeutic development and understand the pathological onset of human disease. For decades, despite marked differences in genetics and etiology, animal models remained the norm for drug discovery and disease modeling.
Yimu Zhao, Erika Yan Wang, Houman Savoji
exaly +6 more sources
Microfluidic heart on a chip for higher throughput pharmacological studies [PDF]
Lab on a Chip, 2013 We present the design of a higher throughput "heart on a chip" which utilizes a semi-automated fabrication technique to process sub millimeter sized thin film cantilevers of soft elastomers. Anisotropic cardiac microtissues which recapitulate the laminar architecture of the heart ventricle are engineered on these cantilevers.
Agarwal, Ashutosh +4 more
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Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform [PDF]
Matrix Biology, 2020 Organ-on-a-chip systems have the potential to revolutionize drug screening and disease modeling through the use of human stem cell-derived cardiomyocytes. The predictive power of these tissue models critically depends on the functional assembly and maturation of human cells that are used as building blocks for organ-on-a-chip systems.
Yimu Zhao +2 more
exaly +5 more sources
Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip [PDF]
Lab on a Chip, 2011 Traditionally, muscle physiology experiments require multiple tissue samples to obtain morphometric, electrophysiological, and contractility data. Furthermore, these experiments are commonly completed one at a time on cover slips of single cells, isotropic monolayers, or in isolated muscle strips.
Grosberg, Anna +3 more
openaire +5 more sources