Results 61 to 70 of about 18,381,159 (295)

Formation and Maintenance of Tissue Resident Memory CD8+ T Cells after Viral Infection

Pathogens, 2019
Tissue resident memory (TRM) CD8 T cells comprise a memory population that forms in peripheral, non-lymphoid tissues after an infection that does not recirculate into the bloodstream or other tissues.
David J. Topham, Emma C. Reilly, Kris Lambert Emo, Mike Sportiello   +3 more
doaj   +1 more source

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8⁺ T cells.

, 2016
Tissue-resident memory CD8+ T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of TRM cell fate in tissue-infiltrating
Kastenmüller, Wolfgang, Drexler, I., Hessel, Christian, Tao, Ronny, Korn, Thomas, Gasteiger, Georg, Tao, R., Koenig, Paul-Albert, Busch, D.H., Tao, Sha, Anne Fellenzer, Busch, Dirk H., Heikenwalder, Mathias, Muschaweckh, Andreas, König, P.A, Andreas Muschaweckh, Georg Gasteiger, Paul-Albert König, Wolfgang Kastenmüller, Dirk H. Busch, Fellenzer, Anne, Kastenmüller, G., Ingo Drexler, Heikenwälder, M., Gasteiger, G., Sha Tao, Fellenzer, A., Buchholz, V.R., Thomas Korn, Tao, S., Christian Hessel, Veit R. Buchholz, Mathias Heikenwälder, Ronny Tao, Hessel, C., Korn, T., Muschaweckh, A., Buchholz, Veit R., Drexler, Ingo   +38 more
core   +2 more sources

Langerhans Cells Directly Interact with Resident T Cells in the Human Epidermis

JID Innovations
Adult human skin contains nearly twice as many T cells as the peripheral blood, which include tissue-resident memory T cells. However, the precise mechanisms maintaining tissue-resident memory T cells in the healthy skin remain unclear.
Tomonori Oka, Tatsuya Hasegawa, Truelian Lee, Valeria S. Oliver-Garcia, Mahsa Mortaja, Marjan Azin, Satoshi Horiba, Sabrina S. Smith, Sara Khattab, Kathryn E. Trerice, Steven T. Chen, Yevgeniy R. Semenov, Shadmehr Demehri   +12 more
doaj   +1 more source

Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment

Cell Reports, 2019
Summary: Tissue-resident memory T (Trm) cells are described as having a “sensing and alarming” function, meaning they can rapidly release cytokines in response to local cognate antigen recognition, which in turn, draws circulating immune cells into the ...
Chenghao Ge, Ian R. Monk, Angela Pizzolla, Nancy Wang, James G. Bedford, Timothy P. Stinear, Glen P. Westall, Linda M. Wakim   +7 more
doaj   +1 more source

Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. [PDF]

PLoS ONE, 2011
Recent studies have shown that tissue resident memory T cells (T(RM)) are critical to antiviral host defense in peripheral tissues. This new appreciation of T(RM) that reside in epithelial tissues and mediate host defense has been studied most ...
Rahul Purwar, James Campbell, George Murphy, William G Richards, Rachael A Clark, Thomas S Kupper   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)

Медицинская иммунология, 2018
Memory T cells are necessary for development of the immune response and represent one of the most numerous population of human T lymphocytes. On the contrary, suppressive regulatory T cells (Tregs) may terminate the immune response and help to maintain ...
E. K. Oleinik, A. V. Churov, V. M. Oleinik   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Monocyte-Derived Cells in Tissue-Resident Memory T Cell Formation [PDF]

The Journal of Immunology, 2020
Abstract There is currently much interest in how different dendritic cell and macrophage populations contribute to T cell–mediated immunity. Although conventional dendritic cell subsets have received much attention for their role in T cell priming, there is emerging evidence for a role for monocyte-derived APC (MoAPC) in tissue-resident ...
Kuan-Lun Chu, Nathália V Batista, Mélanie Girard, Tania H Watts   +3 more
openaire   +2 more sources

Advances in the Study of Tissue-resident Memory T Cells in Lung Cancer

Chinese Journal of Lung Cancer, 2022
Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of lung cancer, but the benefit population is limited and there is a lack of effective predictive markers of efficacy.
Sihan TAN, Panwen TIAN
doaj   +1 more source