Results 51 to 60 of about 18,381,159 (295)

Deficient resident memory T-cell and Cd8 T-cell response to commensals in inflammatory bowel disease [PDF]

, 2019
Background & Aims: The intestinal microbiota is closely associated with resident memory lymphocytes in mucosal tissue. We sought to understand how acquired cellular and humoral immunity to the microbiota differ in health versus inflammatory bowel disease
Samuel P Costello, Carding, SR, Pring, Toby, Akbar, A, O'Connor, Matthew J., Philip Hendy, Pooja Datt, Man, R, Segal, Jonathan, Ailsa L Hart, Datt, Pooja, Anne L Mccartney, Toby Pring, Reddi, D, Ana Wilson, Segal, J, Man, Ripple, Lydia Durant, Bouri, Sonia, Stella C Knight, Datt, P, Reddi, Durga, Jonathan Segal, Sonia Bouri, Knight, SC, Hart, AL, Ayesha Akbar, Pring, T, Costello, SP, Naila Arebi, Simon R Carding, Lesley Hoyles, Durant, Lydia, Arebi, Naila, O’Connor, Matthew J., Durga Reddi, Hendy, P, McCartney, Anne L., Hart, Ailsa L., Hoyles, Lesley, Wilson, Ana, Dennis N F Lim, Noble, Alistair, Durant, L, Ripple Man, Carding, Simon R., McCartney, AL, Lim, DNF, Arebi, N, Bouri, S, Akbar, Ayesha, Alistair Noble, Lim, Dennis N. F., Costello, Samuel P., Matthew J O’Connor, Hoyles, L, Knight, Stella C., Noble, A, O'Connor, MJ, Hendy, Philip, Wilson, A, Akbar, A., McCartney, A.L., Segal, J., Costello, S.P., Arebi, N., Man, R., Reddi, D., Carding, S.R., O'Connor, M.J., Pring, T., Carding, Simon, Durant, L., Lim, D.N.F., Knight, Stella, Noble, A., Datt, P., Hoyles, L., Hart, A.L., Knight, S.C., Wilson, A., Bouri, S., O'Connor, Matthew, Hendy, P.   +83 more
core   +3 more sources

Tissue-resident memory T cells in tumor immunity and immunotherapy

Journal of Experimental Medicine, 2021
Tissue-resident memory T cells (TRM) represent a heterogeneous T cell population with the functionality of both effector and memory T cells. TRM express residence gene signatures. This feature allows them to traffic to, reside in, and potentially patrol peripheral tissues, thereby enforcing an efficient long-term immune-protective role.
Karolina Okła, Donna L. Farber, Weiping Zou   +2 more
openaire   +2 more sources

Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses

, 2021
Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue ...
Son, Young Min, Wang, Zheng, Taylor, Justin J., Chen, Yao, Sun, Jie, Takahashi, Yoshimasa, Kaplan, Mark H., Gao, Xiaochen, Fu, Yang-Xin, Wu, Yue, Cheon, In Su, Li, Chaofan, Dent, Alexander L., Cui, Weiguo, Xiaochen Gao, Weiguo Cui, Mark H. Kaplan, Alexander L. Dent, Zheng Wang, Yoshimasa Takahashi, Yue Wu, Jie Sun, Yang-Xin Fu, In Su Cheon, Yao Chen, Young Min Son, Chaofan Li, Justin J. Taylor   +27 more
core   +1 more source

Single-cell profiling defines the prognostic benefit of CD39high tissue resident memory CD8+ T cells in luminal-like breast cancer

Communications Biology, 2021
Losurdo et al analyze breast cancer-infiltrating T cells by single-cell technologies . The find that the extent of infiltration of a small subset of tissue-resident memory CD8+ T cells identify patients with improved survival, highlighting the importance
Agnese Losurdo, Caterina Scirgolea, Giorgia Alvisi, Jolanda Brummelman, Valentina Errico, Luca Di Tommaso, Karolina Pilipow, Federico Simone Colombo, Bethania Fernandes, Clelia Peano, Alberto Testori, Corrado Tinterri, Massimo Roncalli, Armando Santoro, Emilia Maria Cristina Mazza, Enrico Lugli   +15 more
doaj   +1 more source

FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells [PDF]

, 2023
Although tissue-resident memory T (TRM) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain TRM cells following immune therapy has not been observed in the context of glioblastoma.
Kong, Lingyuan, Yi, Sofia F, Masopust, David, Hashizume, Rintaro, Hu, Jiemiao, Heimberger, Amy B, Jia, Zhiliang, Wang, Jing, Li, Shulin, Tian, Xiangjun, Zhao, Qingnan, Dao, Long Hoang, Jiang, Shan, Fowlkes, Natalie Wall, Yan, Jun, Xia, Xueqing, David Masopust, Shulin Li, Heimberger, Amy B., Xiangjun Tian, Natalie Wall Fowlkes, Amy B. Heimberger, Jun Yan, Rintaro Hashizume, Long Hoang Dao, Shan Jiang, Zhiliang Jia, Qingnan Zhao, Jing Wang, Sofia F. Yi, Lingyuan Kong, Xueqing Xia, Jiemiao Hu, Yi, Sofia F.   +33 more
core   +1 more source

Assessing the generation of tissue resident memory T cells by vaccines

Nature Reviews Immunology, 2023
Vaccines have been a hugely successful public health intervention, virtually eliminating many once common diseases of childhood. However, they have had less success in controlling endemic pathogens including Mycobacterium tuberculosis, herpesviruses and HIV.
Elizabeth Rotrosen, Thomas S. Kupper
openaire   +2 more sources

Tissue-resident memory T cells in renal autoimmune diseases

Frontiers in Immunology, 2023
The discovery of tissue-resident memory T cells (TRM cells) reinterpreted the potential of human tissue-specific immunity. Following T cell receptor (TCR) activation and clonal expansion, effector T cells migrate to peripheral tissues where they remain long-term and differentiate to TRM cells after antigen clearance.
Pauline Ginsberg, Ulf Panzer, Nariaki Asada   +2 more
openaire   +3 more sources

Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection

Cell Reports, 2019
Summary: Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice.
Ichiro Misumi, Joshua Starmer, Toru Uchimura, Melinda A. Beck, Terry Magnuson, Jason K. Whitmire   +5 more
doaj   +1 more source

Tissue-resident memory T cells: Local guards of the thymus [PDF]

, 2013
T-cell surveillance of nonlymphoid tissues has traditionally been ascribed to recirculating memory T cells that continuously patrol the body. Extending this concept, recent evidence suggests that T cells also exist as nonmigratory memory cells that ...
Mackay, LK, Gebhardt, T
core   +1 more source

Tissue-resident memory CD8+ T cells and their role in the immune response to infection and vaccination

Инфекция и иммунитет
A variety of body tissues contain tissue-resident memory CD8+ T cells — long-lived multifunctional effector cells formed during the immune response to infection, which populate previously infected tissue long term.
Vladimir Y. Talayev, Olga N. Babaykina, Maria V. Svetlova, Irina Y. Zaichenko, Elena V. Kurkova   +4 more
doaj   +1 more source