Results 41 to 50 of about 18,381,159 (295)

The Roles of Tissue-Resident Memory T Cells in Lung Diseases [PDF]

Frontiers in Immunology, 2021
The unique environment of the lungs is protected by complex immune interactions. Human lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen entry points and play an essential role in fighting against viral and bacterial pathogens at the frontline through direct mechanisms and also by orchestrating the adaptive immune ...
Rui Yuan, Jiang Yu, Ziqiao Jiao, Jinfei Li, Fang Wu, Rongkai Yan, Xiaojie Huang, Chen Chen, Chen Chen   +8 more
openaire   +3 more sources

Tissue resident memory T cells and viral immunity [PDF]

Current Opinion in Virology, 2017
Tissue resident memory T cells (TRM) constitute a recently identified T cell lineage that is responsible for frontline defense against viral infections. In contrast to central and effector memory T cells, which constitutively recirculate between tissues and blood, TRM reside permanently within tissues. As the main surveyors of non-lymphoid tissues, TRM
Pamela C, Rosato, Lalit K, Beura, David, Masopust   +2 more
openaire   +2 more sources

Targeted Expansion of Tissue-Resident CD8+ T Cells to Boost Cellular Immunity in the Skin

Cell Reports, 2019
Summary: Tissue-resident memory (TRM) CD8+ T cells are positioned within environmental barrier tissues to provide a first line of defense against pathogen entry, but whether these specialized T cell populations can be readily boosted to increase ...
Samuel J. Hobbs, Jeffrey C. Nolz
doaj   +1 more source

An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage. [PDF]

Sci Rep, 2017
When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is ...
Southcombe JH, Mounce G, McGee K, Elghajiji A, Brosens J, Quenby S, Child T, Granne I.   +7 more
europepmc   +2 more sources

Formation of Tissue-Resident CD8⁺ T-Cell Memory [PDF]

Cold Spring Harbor Perspectives in Biology, 2021
Resident memory CD8+ T (Trm) cells permanently reside in nonlymphoid tissues where they act as a first line of defense against recurrent pathogens. How and when antigen-inexperienced CD8+ T cells differentiate into Trm has been a topic of major interest, as knowledge on how to steer this process may be exploited in the development of vaccines and ...
Feline E, Dijkgraaf, Lianne, Kok, Ton N M, Schumacher   +2 more
openaire   +2 more sources

Transcriptional control of tissue-resident memory T cell generation [PDF]

, 2019
Tissue-resident memory T cells (TRM) are a non-circulating subset of memory that are maintained at sites of pathogen entry and mediate optimal protection against reinfection.
Cvetkovski, Filip
core   +1 more source

A Novel Technique for the Generation of Substantial Numbers of Functional Resident T Cells from Kidney Tissue

Cells, 2022
Studying functionality and antigen-specificity of resident kidney T cells derived from a kidney biopsy is hampered by the lack of sufficient numbers of T cells obtained by the standard method of enzymatic tissue dissociation.
Michiel G. H. Betjes, Frederique Prevoo, Thierry P. P. van den Bosch, Mariska Klepper, Nicolle H. R. Litjens   +4 more
doaj   +1 more source

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Cell Reports, 2018
Summary: Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoite challenge.
Lauren E. Holz, Julia E. Prier, David Freestone, Thiago M. Steiner, Kieran English, Darryl N. Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M. Davey, Dale I. Godfrey, Katsuyuki Yui, Laura K. Mackay, Mireille H. Lahoud, Irina Caminschi, Geoffrey I. McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R. Heath   +17 more
doaj   +1 more source

Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection

Nature Communications, 2023
Resident memory T cells at the respiratory tract may play critical roles in the response to respiratory infections including SARS-CoV-2. Here the authors characterise the lung resident T cell response generated in response to mRNA vaccination of SARS-CoV-
Daan K. J. Pieren, Sebastián G. Kuguel, Joel Rosado, Alba G. Robles, Joan Rey-Cano, Cristina Mancebo, Juliana Esperalba, Vicenç Falcó, María J. Buzón, Meritxell Genescà   +9 more
doaj   +1 more source

Rapid turnover of effector-memory CD4(+) T cells in healthy humans [PDF]

, 2004
Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar ...
Peter C.L. Beverley, Macallan, DC, Griffin, GE, George E. Griffin, Andrew T. Worth, Derek C. Macallan, Wallace, Diana, Diana Wallace, Ghattas, Hala, Zhang, Yan, Griffin, George E, Macallan, Derek C, Zhang, Y, Ghattas, H, Beverley, Peter CL, Tough, David F, Hala Ghattas, Tough, DF, David F. Tough, De Lara, C, De Lara, Catherine, Beverley, PC, Yan Zhang, Catherine de Lara, Wallace, D, Worth, Andrew T, Worth, AT   +26 more
core   +1 more source