Results 21 to 30 of about 18,381,159 (295)

Regulation of tissue-resident memory T cells by the Microbiota [PDF]

Mucosal Immunology, 2022
Resident memory T cells (Trms) predominantly reside within tissue and are critical for providing rapid protection against invasive viruses, fungi and bacteria. Given that tissues are heavily impacted and shaped by the microbiota, it stands to reason that Trms are also influenced by the microbiota that inhabits barrier sites.
Abigail E. Overacre-Delgoffe, Timothy W. Hand   +1 more
openaire   +2 more sources

Divergent molecular networks program functionally distinct CD8+skin-resident memory T cells

, 2023
Skin-resident CD8+T cells include distinct interferon-g-producing [tissue-resident memory T type 1 (TRM1)] and interleukin-17 (IL-17)-producing (TRM17) subsets that differentially contribute to immune responses.
Kannourakis, George, Berzins, Stuart, Guillaume, Stephane, Wang, Huimeng, Zaid, Ali, Alexandre, Yannick, Evrard, Maximilien, Schröder, Jan, Davies, Brooke, Mueller, Scott, Carbone, Francis, Collins, Nicholas, Castellucci, Clara, Osman, Maleika, Park, Simone, Gandolfo, Luke, Mielke, Lisa, Belkaid, Yasmine, Han, Seong-Ji, Kallies, Axel, Mackay, Laura, Wells, Alexandria, Burn, Thomas, Speed, Terence, McDonald, Keely, Obers, Andreas, Christo, Susan, Zaid, A, Park, SL, Collins, N, Christo, SN, Evrard, M, Davies, B, Schröder, J, Han, SJ, Guillaume, SM, Burn, TN, Osman, M, Wells, AC, Castellucci, C, Gandolfo, LC, Alexandre, YO, et al.   +42 more
core   +3 more sources

Tissue resident memory T cells in the respiratory tract [PDF]

Mucosal Immunology, 2022
Owing to their capacity to rapidly spread across the population, airborne pathogens represent a significant risk to global health. Indeed, several of the past major global pandemics have been instigated by respiratory pathogens. A greater understanding of the immune cells tasked with protecting the airways from infection will allow for the development ...
Zheng, Ming Z. M., Wakim, Linda M.
openaire   +2 more sources

Tissue-Resident Memory T Cells [PDF]

Immunity, 2014
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance.
Schenkel, Jason M., Masopust, David
openaire   +2 more sources

Tissue‐resident memory T cells [PDF]

Immunological Reviews, 2013
SummaryTissues such as the genital tract, skin, and lung act as barriers against invading pathogens. To protect the host, incoming microbes must be quickly and efficiently controlled by the immune system at the portal of entry. Memory is a hallmark of the adaptive immune system, which confers long‐term protection and is the basis for efficacious ...
Haina, Shin, Akiko, Iwasaki
openaire   +2 more sources

Tissue-resident memory T cells in the kidney

Seminars in Immunopathology, 2022
Abstract The identification of tissue-resident memory T cells (T RM cells) has significantly improved our understanding of immunity. In the last decade, studies have demonstrated that T RM cells are induced after an acute T-cell ...
Nariaki Asada, Pauline Ginsberg, Nicola Gagliani, Hans-Willi Mittrücker, Ulf Panzer   +4 more
openaire   +2 more sources

Tissue-resident memory CD8(+)T cells shape local and systemic secondary T cell responses [PDF]

, 2020
Tissue-resident memory CD8(+)T cells (T(RM)cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear.
Arens, R., Parga-Vidal, L., Lier, R.A.W. van, Behr, F.M., Dam, T.J.P. van, Sheridan, B.S., Wesselink, T.H., Gisbergen, K.P.J.M. van, Kragten, N.A.M., Stark, R.   +9 more
core   +1 more source

Tissue-Resident Memory T Cell: Ontogenetic Cellular Mechanism and Clinical Translation [PDF]

, 2023
Mounting evidence has indicated the essential role of tissue-resident memory T (TRM) cells for frontline protection against viral infection and for cancer immune surveillance (Mueller SN, Mackay LK.
Zhou, Runhong, Chen, Zhiwei, Runhong Zhou, Zhiwei Chen, Haoran Xu, Xu, Haoran   +5 more
core   +1 more source

Engineering Vaccines for Tissue‐Resident Memory T Cells

Advanced Therapeutics, 2021
Abstract In recent years, tissue‐resident memory T cells (T RM ) have attracted significant attention in the field of vaccine development. Distinct from central and effector memory T cells, T RM cells take up residence in home tissues ...
Frances C. Knight, John T. Wilson
openaire   +3 more sources

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer [PDF]

, 2023
CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (TRM) cell phenotype are associated with favorable prognosis in patients with triple-negative breast cancer (TNBC).
Lucas, O, Sant, S, Loi, S, Brown, E, Caramia, F, Savas, P, Weber, K, Mackay, LK, Wang, J, Swanton, C, Freestone, D, Luen, SJ, Christo, SN, Byrne, A, Loibl, S, von Scheidt, B, Neeson, PJ, Darcy, PK, Virassamy, B, Teply-Szymanski, J, Speed, TP, Teo, ZL, Denkert, C, Gandolfo, LC, Clarke, K, Li, R   +25 more
core   +3 more sources