Results 1 to 10 of about 18,381,159 (295)

CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types [PDF]

Nature Communications, 2023
Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory
Leandro Barros, Daryna Piontkivska, Patrícia Figueiredo-Campos, Júlia Fanczal, Sofia Pereira Ribeiro, Marta Baptista, Silvia Ariotti, Nuno Santos, Maria João Amorim, Cristina Silva Pereira, Marc Veldhoen, Cristina Ferreira   +11 more
doaj   +3 more sources

T-cells in human trigeminal ganglia express canonical tissue-resident memory T-cell markers [PDF]

Journal of Neuroinflammation, 2022
Background Trigeminal ganglia (TG) neurons are the main site of lifelong latent herpes simplex virus type 1 (HSV-1) infection. T-cells in ganglia contribute to long-term control of latent HSV-1 infection, but it is unclear whether these cells are bona ...
Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink, Georges M. G. M. Verjans   +5 more
doaj   +2 more sources

Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer [PDF]

Journal for ImmunoTherapy of Cancer, 2020
Background Adenoviral vectors emerged as important platforms for cancer immunotherapy. Vaccination with adenoviral vectors is promising in this respect, however, their specific mechanisms of action are not fully understood.
Paul Klenerman, Suzanne van Duikeren, Ramon Arens, Frits Koning, Hideo Yagita, Esmé TI van der Gracht, Mark JA Schoonderwoerd, Ayse N Yilmaz, Felix M Behr, Julia M Colston, Lian N Lee, Klaas PJM van Gisbergen, Lukas JAC Hawinkels   +12 more
doaj   +2 more sources

Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis

Frontiers in Immunology, 2023
Tissue-resident memory T cells (Trm) are a particular type of T cell subgroup, which stably reside in tissues and have been revealed to be the most abundant memory T cell population in various tissues.
Mengjie Liang, Xingzhou Wang, Daming Cai, Wenxian Guan, Xiaofei Shen   +4 more
doaj   +1 more source

Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability

Journal for ImmunoTherapy of Cancer, 2023
Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome
Qi Zhang, Jiangchao Wu, Tingbo Liang, Xueli Bai, Xun Wang, Jianpeng Sheng, Junlei Zhang, Jianghui Tang, Jinyuan Song, Yongtao Ji   +9 more
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IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection

Nature Communications, 2023
CD8+ T cell tissue resident memory (TRM) cells are especially suited to control pathogen spread at mucosal sites. However, their maintenance in lung is short-lived. TCR-dependent NFkB signaling is crucial for T cell memory but how and when NFkB signaling
Curtis J. Pritzl, Dezzarae Luera, Karin M. Knudson, Michael J. Quaney, Michael J. Calcutt, Mark A. Daniels, Emma Teixeiro   +6 more
doaj   +1 more source

Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies

EMBO Molecular Medicine, 2023
Idiopathic inflammatory myopathies (IIM) are rare autoimmune systemic diseases characterized by muscle weakness and the presence of muscle‐infiltrating T cells.
Alexandra Argyriou, Begum Horuluoglu, Angeles Shunashy Galindo‐Feria, Juan Sebastian Diaz‐Boada, Merel Sijbranda, Antonella Notarnicola, Lara Dani, Annika van Vollenhoven, Daniel Ramsköld, Inger Nennesmo, Maryam Dastmalchi, Ingrid E Lundberg, Lina‐Marcela Diaz‐Gallo, Karine Chemin   +13 more
doaj   +1 more source

T Cell Immunity against Influenza: The Long Way from Animal Models Towards a Real-Life Universal Flu Vaccine

Viruses, 2021
Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains.
Anna Schmidt, Dennis Lapuente
doaj   +1 more source

PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu

Frontiers in Immunology, 2022
Regulatory T cells that express the transcription factor Foxp3 (Treg cells) are a highly heterogenous population of immunoregulatory cells critical for maintaining immune homeostasis and preventing immunopathology during infections. Tissue resident Treg
Michael C. McGee, Tianyi Zhang, Nicholas Magazine, Rezwanul Islam, Mariano Carossino, Weishan Huang, Weishan Huang   +6 more
doaj   +1 more source

T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

Cell Reports, 2020
Summary: T cell factor 1 (Tcf1) promotes the central memory CD8+ T (TCM) cell differentiation and stemness in lymphoid tissues after systemic infections.
Jingxia Wu, Alaa Madi, Alessa Mieg, Agnes Hotz-Wagenblatt, Nina Weisshaar, Sicong Ma, Kerstin Mohr, Tilo Schlimbach, Marvin Hering, Helena Borgers, Guoliang Cui   +10 more
doaj   +1 more source