Heterogeneity of tissue resident memory T cells
Immunology Letters, 2022 Non-lymphoid organs, in mice and humans, contain CD8+ tissue-resident memory T (TRM) cells. They play important roles in tissue homoeostasis as well as defence against infections and cancer. TRM cells have common characteristics that enables their tissue
Iannacone M. +3 more
core +3 more sources
Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence [PDF]
Cell Reports, 2020 Summary: Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionality in
Leo Swadling +17 more
doaj +2 more sources
LOCAL IMMUNITY BY TISSUE-RESIDENT CD8+ MEMORY T CELLS [PDF]
Frontiers in Immunology, 2012 Microbial infection primes a CD8+ cytotoxic T cell response that gives rise to a long-lived population of circulating memory cells able to provide protection against systemic reinfection.
Mackay, LK +5 more
core +6 more sources
Bone marrow T cells and the integrated functions of recirculating and tissue-resident memory T cells [PDF]
Frontiers in Immunology, 2016 Changes in T cell trafficking accompany the naïve to memory T cell antigen-driven differentiation, which remains an incompletely defined developmental step. Upon priming, each naïve T cell encounters essential signals–i.e.
Francesca eDi Rosa, Thomas eGebhardt
doaj +2 more sources
Maintenance of the human memory T cell repertoire by subset and tissue site [PDF]
Genome Medicine, 2021 Background Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circulating effector-
Michelle Miron +9 more
doaj +2 more sources
Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity [PDF]
Frontiers in Immunology, 2018 Resident memory (TRM) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal TRM ...
Aleksey Molodtsov, Mary Jo Turk
doaj +2 more sources
Transcriptional programming of tissue-resident memory CD8+ T cells [PDF]
Current Opinion in Immunology, 2018 Tissue-resident memory CD8+ T cells (TRM) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure.
Goldrath, Ananda W +3 more
core +6 more sources
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. [PDF]
J Exp Med, 2020 CD8+ tissue-resident memory T cells (TRM cells) are poised at the portals of infection and provide long-term protective immunity. Despite their critical roles, the precise mechanics governing TRM cell reactivation in situ are unknown.
Low JS +11 more
europepmc +2 more sources
Tissue-Resident Memory T Cells in Antifungal Immunity [PDF]
Frontiers in Immunology, 2021 Fungi are an integral part of the mammalian microbiota colonizing most if not all mucosal surfaces and the skin. Maintaining stable colonization on these surfaces is critical for preventing fungal dysbiosis and infection, which in some cases can lead to life threatening consequences.
Salomé LeibundGut-Landmann +1 more
openaire +4 more sources
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool. [PDF]
J Exp Med, 2020 International audienceAn increasing body of evidence emphasizes the role of tissue-resident memory T cells (TRM) in the defense against recurring pathogens and malignant neoplasms.
Kok L +8 more
europepmc +3 more sources