Results 31 to 40 of about 18,381,159 (295)

tissue‐resident memory T cells

, 2021
Brain CD8+ CD69+ tissue-resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased.
Fransen, NL, Huitinga, I., Smolders, Joost; id_orcid, Hamann, J., Brandwijk, K.I.M., Hamann, J, Hsiao, C.-C., Joost Smolders, Brandwijk, KIM, Smolders, J., Jörg Hamann, Huitinga, I, van den Bosch, A.M.R., Hsiao, CC, Cheng‐Chih Hsiao, Aletta M.R. van den Bosch, Kim I.M. Brandwijk, Bosch, AMR, Nina L. Fransen, Fransen, N.L., Inge Huitinga   +20 more
core   +1 more source

Tissue‐resident memory T cells and lung immunopathology

Immunological Reviews, 2023
SummaryRapid reaction to microbes invading mucosal tissues is key to protect the host against disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity against pathogen infection and/or re‐infection, due to their presence at the site of pathogen entry. However, there has been emerging evidence that exuberant TRM‐cell responses
In Su Cheon, Young Min Son, Jie Sun
openaire   +2 more sources

Diverse functions of mucosal resident memory T cells [PDF]

, 2015
Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during
Kimberly Sue Schluns, Sue Schluns, Kimberly, Klonowski, Kim, Kim Klonowski   +3 more
core   +1 more source

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue. [PDF]

, 2021
Cross-reactive CD4+ T cells that recognize SARS-CoV-2 are more commonly detected in the peripheral blood of unexposed individuals compared to SARS-CoV-2-reactive CD8+ T cells.
Mazzurana, Luca,, Hodcroft, Emma B., Fehrm, Johan, Mjösberg, Jenny, Karlsson, Annika C., Maric, Jovana,, Lange, Joshua, Niessl, Julia,, Fehrm, Johan,, Forkel, Marianne, Price, David A, Lange, Joshua,, Buggert, Marcus,, Konya, Viktoria, Sundman, Joar, Konya, Viktoria,, Kokkinou, Efthymia,, Buggert, Marcus, Niessl, Julia, Mazzurana, Luca, Sundman, Joar,, Llewellyn-Lacey, Sian, Karlsson, Annika C.,, Kokkinou, Efthymia, Weigel, Whitney, Friberg, Danielle, Llewellyn-Lacey, Sian,, Mjösberg, Jenny,, Sekine, Takuya,, Sekine, Takuya, Price, David A.,, Friberg, Danielle,, Hodcroft, Emma B.,, Weigel, Whitney,, Rao, Anna,, Maric, Jovana, Karlsson, Annika C, Rao, Anna, Price, David A., Forkel, Marianne,, Niessl, J,, Forkel, M, Maric, J, Mazzurana, L, Rao, A, Kokkinou, E, Weigel, W, Konya, V, Sekine, T,, Lange, J, Takuya Sekine, Marianne Forkel, Anna Rao, Joshua Lange, Danielle Friberg, David A. Price, Joar Sundman, Marcus Buggert, Viktoria Konya, Jovana Maric, Luca Mazzurana, Julia Niessl, Emma B. Hodcroft, Jenny Mjösberg, Whitney Weigel, Annika C. Karlsson, Efthymia Kokkinou, Sian Llewellyn-Lacey, Johan Fehrm   +68 more
core   +2 more sources

Tissue-Resident Macrophages Limit Pulmonary CD8 Resident Memory T Cell Establishment

Frontiers in Immunology, 2019
Tissue resident memory CD8 T cells (TRM) serve as potent local sentinels and contribute significantly to protective immunity against intracellular mucosal pathogens.
Nick P. Goplen, Su Huang, Bibo Zhu, In Su Cheon, Young Min Son, Zheng Wang, Chaofan Li, Qigang Dai, Li Jiang, Jie Sun, Jie Sun   +10 more
doaj   +1 more source

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy [PDF]

, 2020
Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, we identified discrete lineages of intestinal antigen ...
Toma, Clara, Milner, J Justin, He, Zhaoren, Crowl, John T, Chang, John T, Kurd, Nadia S, Widjaja, Christella E, Shaw, Laura A, Yeo, Gene W, Goldrath, Ananda W, Witherden, Deborah A, Quezada, Lauren, Nguyen, Quynh P, Omilusik, Kyla D, McDonald, Bryan   +14 more
core   +1 more source

Tissue-resident memory T cell signatures from single-cell analysis associated with better melanoma prognosis. [PDF]

iScience
Summary: Tissue-resident memory T cells (TRM) are a specialized T cell population residing in peripheral tissues. The presence and potential impact of TRM in the tumor immune microenvironment (TIME) remain to be elucidated.
Jiang C, Chao CC, Li J, Ge X, Shen A, Jucaud V, Cheng C, Shen X.   +7 more
europepmc   +2 more sources

Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. [PDF]

, 2011
During human and murine cytomegalovirus (MCMV) infection an exceptionally large virus-specific CD8 T cell pool is maintained in the periphery lifelong.
Torti, Nicole, Oxenius, Annette, Walton, Senta M., Walton Senta M., Rülicke Thomas, Senta M Walton, Torti Nicole, Oxenius Annette, Brocker, Thomas, Senta M. Walton, Rülicke, Thomas, Nicole Torti, Brocker Thomas, Thomas Brocker, Thomas Rülicke, Annette Oxenius, Oxenius A, Torti N, Brocker T, Rülicke T, Walton SM   +20 more
core   +2 more sources

Gut tissue‐resident memory T cells in coeliac disease [PDF]

Scandinavian Journal of Immunology, 2021
AbstractThis mini‐review describes observations of the 1990ies with culturing of gluten‐specific and astrovirus‐specific CD4+ T cells from duodenal biopsies from subjects who presumably had a long time between the exposure to gluten or astrovirus antigens and the sampling of the biopsy.
openaire   +4 more sources

Tissue-resident memory T cells in cytomegalovirus infection [PDF]

Current Opinion in Virology, 2016
Herpesviruses establish life-long infection in their hosts and maintain latent reservoirs for sporadic reactivation at peripheral sites, such as skin and mucosae. For herpes simplex virus infection, experimental studies in mice revealed that immediate protection against local reactivation or superinfection events in the skin relies on tissue resident ...
Thom Jenny Tosca, Oxenius Annette
openaire   +3 more sources