Results 41 to 50 of about 383,742 (286)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications

Frontiers in Bioengineering and Biotechnology, 2021
Decellularization techniques support the creation of biocompatible extracellular matrix hydrogels, providing tissue-specific environments for both in vitro cell culture and in vivo tissue regeneration.
Sara López-Martínez, Hannes Campo, Lucía de Miguel-Gómez, Lucía de Miguel-Gómez, Amparo Faus, Alfredo T. Navarro, Ana Díaz, Antonio Pellicer, Antonio Pellicer, Hortensia Ferrero, Hortensia Ferrero, Irene Cervelló   +11 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Human Skin as an Ex Vivo Model for Maintaining Mycobacterium leprae and Leprosy Studies

Tropical Medicine and Infectious Disease
The in vitro cultivation of M. leprae has not been possible since it was described as causing leprosy, and the limitation of animal models for clinical aspects makes studies on leprosy and bacteria–human host interaction a challenge.
Natália Aparecida de Paula, Marcel Nani Leite, Daniele Ferreira de Faria Bertoluci, Cleverson Teixeira Soares, Patrícia Sammarco Rosa, Marco Andrey Cipriani Frade   +5 more
doaj   +1 more source

Design and Fabrication of Organ-on-Chips: Promises and Challenges

Micromachines, 2021
The advent of the miniaturization approach has influenced the research trends in almost all disciplines. Bioengineering is one of the fields benefiting from the new possibilities of microfabrication techniques, especially in cell and tissue culture ...
Alireza Tajeddin, Nur Mustafaoglu
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Agrobacterium rhizogenes-Based Transformation of Soybean Roots to Form Composite Plants

Bio-Protocol, 2016
Transgenic soybean roots of composite plants are a powerful tool to rapidly test the function of genes and activity of gene promoters. No tissue culture is needed, thus avoiding loss of valuable material due to contamination.
Benjamin Matthews, Reham Youssef
doaj   +1 more source

Behavior and biocompatibility of rabbit bone marrow mesenchymal stem cells with bacterial cellulose membrane [PDF]

PeerJ, 2018
Background Tissue engineering has been shown to exhibit great potential for the creation of biomaterials capable of developing into functional tissues.
Marcello de Alencar Silva, Yulla Klinger de Carvalho Leite, Camila Ernanda Sousa de Carvalho, Matheus Levi Tajra Feitosa, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Bartolomeu Cruz Viana Neto, Maria Angélica Miglino, Angela Faustino Jozala, Maria Acelina Martins de Carvalho   +9 more
doaj   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source