Results 51 to 60 of about 1,427,308 (312)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Comparison between traditional and digital anterior repositioning splints on the upper airway in skeletal class II malocclusion with TMJ degenerative disease

Scientific Reports
This retrospective observational study compared the effects of traditional Anterior Repositioning Splint (ARS) and digital ARS on the upper airway of patients with skeletal Class II malocclusion and temporomandibular joint degenerative joint disease.
Shufang Luo, Lei Xu, Yaqun Deng, Yaxin Zheng, Qianju Wu, Zhisheng Zhang, Jinyi He, Erle Lin   +7 more
doaj   +1 more source

Mechanisms of tissue degeneration mediated by periostin in spinal degenerative diseases and their implications for pathology and diagnosis: a review [PDF]

, 2023
Tomohito Yoshihara, Tadatsugu Morimoto, Hirohito Hirata, Masatoshi Murayama, Toshihiro Nonaka, Masatsugu Tsukamoto, Yu Toda, Takaomi Kobayashi, Kenji Izuhara, Masaaki Mawatari   +9 more
openalex   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells

Scientific Reports
Inflammation is a key factor in neurodegenerative diseases (NDs) development, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Microglial cells maintain immune microenvironment homeostasis in the central nervous system (CNS) and are ...
Xiaoxuan Wang, Haozhe Tian, Shifei Chen, Liangliang Ying, Juan Zheng, Yaya Song, Jin Xi, Yuxin Zhang, Dong Wang   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exploring the feasibility of AI-based analysis of histopathological variability in salivary gland tumours

Scientific Reports
This study uses artificial intelligence (AI) for differentiation between salivary gland tumours (SGT) using digitised Haematoxylin and Eosin stained whole-slide images (WSI).
Ibrahim Alsanie, Adam Shephard, Neda Azarmehr, Pablo Vargas, Miranda Pring, Nasir M. Rajpoot, Syed Ali Khurram   +6 more
doaj   +1 more source

Survey of the initial management of celiac disease antibody tests by ordering physicians

BMC Pediatrics, 2019
Background Appropriate interpretation of a positive celiac antibody test by an ordering physician is important in order to institute proper management.
Kathryn Potter, Lawrence de Koning, J. Decker Butzner, Dominica Gidrewicz   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source