Results 1 to 10 of about 12,729,869 (376)

Tissue Distribution and Abundance of the Parasitic Dinoflagellate Hematodinium perezi in Naturally Infected Portunus trituberculatus [PDF]

open access: yesPathogens
The parasitic dinoflagellate Hematodinium is an infectious pathogen that causes severe enzootic in numerous economically important marine crustaceans worldwide.
Ju Zhang   +6 more
doaj   +2 more sources

Tissue Distribution Study of Poloxamer188 in Rats by Ultra-High-Performance Liquid Chromatography Quadrupole Time of Flight/Mass Spectrometry with MSALL-Based Approach

open access: yesMolecules, 2021
Poloxamer188 (PL188), as one of the most commonly used pharmaceutical excipients, has unique physicochemical properties and good biocompatibility, and so is playing an increasingly extensive role in the field of medicine. Currently, there are few studies
Yixuan Feng   +7 more
doaj   +1 more source

Evaluation of the activity of cyanide-metabolizing sulfurtransferase enzymes in different tissues of turkey (Meleagris gallopavo) [PDF]

open access: yesThe Iranian Journal of Veterinary Science and Technology, 2015
This study was undertaken to estimate specific activities of rhodanese and 3-mercaptopyruvate sulfurtransferase (MST) in different tissues of turkey.
Kamal JalilianKabiri, Hassan Baghishani
doaj   +1 more source

Human tissue distribution of caspofungin

open access: yesInternational Journal of Antimicrobial Agents, 2022
Tissue concentrations of caspofungin were determined in nine clinically relevant tissues taken during routine autopsy of 20 patients who had died during caspofungin treatment or within 23 days of cessation. The highest levels were achieved in liver, with concentrations ranging from ≤0.50 to 91.5 µg/g (0.60 µg/g 21 days after the last administration ...
Jana Marx   +7 more
openaire   +2 more sources

Optimization, and in vitro and in vivo evaluation of etomidate intravenous lipid emulsion

open access: yesDrug Delivery, 2021
The aim of this investigation was to develop an etomidate intravenous lipid emulsion (ETM-ILE) and evaluate its properties in vitro and in vivo. Etomidate (ETM) is a hydrophobic drug, and organic solvents must be added to an etomidate injectable solution
Dandan Geng   +8 more
doaj   +1 more source

Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models

open access: yesDrug Delivery, 2021
Background Combination of the prodrug technique with an albumin nano drug-loaded system is a novel promising approach for cancer treatment. However, the long-lasting and far-reaching challenge for the treatment of cancers lies in how to construct the ...
Hang Chen   +14 more
doaj   +1 more source

Microvascular and tissue oxygen distribution [PDF]

open access: yesCardiovascular Research, 1996
Understanding of oxygen delivery by the microcirculation has been dominated by the unitary component analysis of Krogh and Erlangen focussed on oxygen transport mediated by single capillaries, oxygenation of tissue as a whole being extrapolated from findings on oxygen exchange in these vessels.
M, Intaglietta   +2 more
openaire   +2 more sources

Molecular Characterization and Dietary Regulation of Glutaminase 1 (gls1) in Triploid Crucian Carp (Carassius auratus)

open access: yesFishes, 2022
Kidney-type glutaminase, encoded by the gls1 gene, plays a critical role in glutamate production and improvement of meat flavor. In this study, a gls1 gene encoding 595 amino acids was cloned from triploid crucian carp (Carassius auratus) (TCC) and ...
Yangbo Xiao   +14 more
doaj   +1 more source

Human Tissue Distribution of Voriconazole [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 2011
ABSTRACT Voriconazole concentrations were determined in autopsy samples of eight patients who had been treated for a median of 7 days (interquartile range [IQR], 5 days). Voriconazole penetrates well into various tissues, with median levels of 6.26 μg/g ((interquartile range [IQR], 7.87 μg/g) in the lung, 3.41 μg/g (IQR, 16.72 μg/g) in the ...
Stefan, Weiler   +7 more
openaire   +2 more sources

Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs: Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route

open access: yesPharmaceutics, 2022
Carprofen (CP) is a non-steroidal anti-inflammatory drug (NSAID) frequently used to treat respiratory diseases in numerous small animals, but also in large species.
Lidia Gómez-Segura   +8 more
doaj   +1 more source

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