Results 1 to 10 of about 3,009,910 (332)

THE DISTRIBUTION OF METABOLITES IN THE BLOOD AND TISSUES [PDF]

open access: greenArchives of Internal Medicine, 1922
INTRODUCTION With the introduction of simple and reliable microchemical methods of analysis, the determination of the concentration of metabolites in the blood has become an accepted clinical procedure. Consequently, the relation of metabolites in the blood to their distribution throughout the entire organism is a subject of clinical as well as ...
Harold Rypins
openalex   +4 more sources

DISTRIBUTION OF PROSTAGLANDINS IN HUMAN TISSUES [PDF]

open access: greenBritish Journal of Pharmacology and Chemotherapy, 1967
The concentrations of prostaglandins present in 23 types of human tissues was estimated. Tissues were obtained from necropsy examinations of adult patients carried out within 24 hours. All tissues were macroscopically free of disease and in most instances were examined histologically to confirm this. The preparation used was shown to be sensitive to
S.M.M. Karim, M. Sandler, E. D. Williams
openalex   +5 more sources

Tissue Distribution Study of Poloxamer188 in Rats by Ultra-High-Performance Liquid Chromatography Quadrupole Time of Flight/Mass Spectrometry with MSALL-Based Approach

open access: yesMolecules, 2021
Poloxamer188 (PL188), as one of the most commonly used pharmaceutical excipients, has unique physicochemical properties and good biocompatibility, and so is playing an increasingly extensive role in the field of medicine. Currently, there are few studies
Yixuan Feng   +7 more
doaj   +1 more source

Evaluation of the activity of cyanide-metabolizing sulfurtransferase enzymes in different tissues of turkey (Meleagris gallopavo) [PDF]

open access: yesThe Iranian Journal of Veterinary Science and Technology, 2015
This study was undertaken to estimate specific activities of rhodanese and 3-mercaptopyruvate sulfurtransferase (MST) in different tissues of turkey.
Kamal JalilianKabiri, Hassan Baghishani
doaj   +1 more source

Optimization, and in vitro and in vivo evaluation of etomidate intravenous lipid emulsion

open access: yesDrug Delivery, 2021
The aim of this investigation was to develop an etomidate intravenous lipid emulsion (ETM-ILE) and evaluate its properties in vitro and in vivo. Etomidate (ETM) is a hydrophobic drug, and organic solvents must be added to an etomidate injectable solution
Dandan Geng   +8 more
doaj   +1 more source

Tissue and subcellular distribution of CLIC1 [PDF]

open access: yesBMC Cell Biology, 2007
Abstract Background CLIC1 is a chloride channel whose cellular role remains uncertain. The distribution of CLIC1 in normal tissues is largely unknown and conflicting data have been reported regarding the cellular membrane fraction in which CLIC1 resides.
Barbara Ulmasov   +3 more
openaire   +4 more sources

Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models

open access: yesDrug Delivery, 2021
Background Combination of the prodrug technique with an albumin nano drug-loaded system is a novel promising approach for cancer treatment. However, the long-lasting and far-reaching challenge for the treatment of cancers lies in how to construct the ...
Hang Chen   +14 more
doaj   +1 more source

Molecular Characterization and Dietary Regulation of Glutaminase 1 (gls1) in Triploid Crucian Carp (Carassius auratus)

open access: yesFishes, 2022
Kidney-type glutaminase, encoded by the gls1 gene, plays a critical role in glutamate production and improvement of meat flavor. In this study, a gls1 gene encoding 595 amino acids was cloned from triploid crucian carp (Carassius auratus) (TCC) and ...
Yangbo Xiao   +14 more
doaj   +1 more source

Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs: Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route

open access: yesPharmaceutics, 2022
Carprofen (CP) is a non-steroidal anti-inflammatory drug (NSAID) frequently used to treat respiratory diseases in numerous small animals, but also in large species.
Lidia Gómez-Segura   +8 more
doaj   +1 more source

Antiviral effects and tissue exposure of tetrandrine against SARS‐CoV‐2 infection and COVID‐19

open access: yesMedComm, 2023
Tetrandrine (TET) has been used to treat silicosis in China for decades. The aim of this study was to facilitate rational repurposing of TET against SARS‐CoV‐2 infection. In this study, we confirmed that TET exhibited antiviral potency against SARS‐CoV‐2
Jia Liu   +18 more
doaj   +1 more source

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