Results 11 to 20 of about 1,698,009 (248)

Molecular Characterization and Dietary Regulation of Glutaminase 1 (gls1) in Triploid Crucian Carp (Carassius auratus)

Fishes, 2022
Kidney-type glutaminase, encoded by the gls1 gene, plays a critical role in glutamate production and improvement of meat flavor. In this study, a gls1 gene encoding 595 amino acids was cloned from triploid crucian carp (Carassius auratus) (TCC) and ...
Yangbo Xiao, Rong Huang, Shenping Cao, Dafang Zhao, Zhuangwen Mao, Chuchu Xiao, Zhehua Xu, Xiaomei Zhou, Xinran Zhang, Yu Zhang, Jianzhou Tang, Junyan Jin, Yaoguo Li, Jun Zou, Zhen Liu   +14 more
doaj   +1 more source

Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs: Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route

Pharmaceutics, 2022
Carprofen (CP) is a non-steroidal anti-inflammatory drug (NSAID) frequently used to treat respiratory diseases in numerous small animals, but also in large species.
Lidia Gómez-Segura, Antoni Boix-Montañes, Mireia Mallandrich, Alexander Parra-Coca, José L. Soriano-Ruiz, Ana Cristina Calpena, Álvaro Gimeno, David Bellido, Helena Colom   +8 more
doaj   +1 more source

Antiviral effects and tissue exposure of tetrandrine against SARS‐CoV‐2 infection and COVID‐19

MedComm, 2023
Tetrandrine (TET) has been used to treat silicosis in China for decades. The aim of this study was to facilitate rational repurposing of TET against SARS‐CoV‐2 infection. In this study, we confirmed that TET exhibited antiviral potency against SARS‐CoV‐2
Jia Liu, Furun Wang, Xi Wang, Shiyong Fan, Yufeng Li, Mingyue Xu, Hengrui Hu, Ke Liu, Bohong Zheng, Lingchao Wang, Huanyu Zhang, Jiang Li, Wei Li, Wenpeng Zhang, Zhihong Hu, Ruiyuan Cao, Xiaomei Zhuang, Manli Wang, Wu Zhong   +18 more
doaj   +1 more source

A Pyridazinone Compound for Effectively Treating Non-alcoholic Steatohepatitis by Targeting THRβ

Frontiers in Chemistry, 2022
Developing effective therapies and medicines to conquer nonalcoholic steatohepatitis (NASH) is of great significance for public health and is faced with a major challenge.
Hao Cheng, Hao Cheng, Hao Cheng, Hao Cheng, Xiao-Bo Wang, Xiao-Bo Wang, Ying Zhi, Ying Zhi, Ying Zhi, Ying Zhi, Bo Liu, Bo Liu, Bo Liu, Bo Liu, Na Liu, Meng-Jun Li, Yan-Ling Mu, Yan-Ling Mu, Yan-Ling Mu, Yan-Ling Mu   +19 more
doaj   +1 more source

Effects of Huangqi Liuyi Decoction in the Treatment of Diabetic Nephropathy and Tissue Distribution Difference of its Six Active Constituents Between Normal and Diabetic Nephropathy Mouse Models

Frontiers in Pharmacology, 2022
The purpose of this study was to investigate the effects of Huangqi Liuyi decoction extract (HQD) on diabetic nephropathy (DN), and the tissue distribution difference of six main active ingredients of HQD between normal and DN mouse models.
Qun Wang, Ya Shi, Zengguang Wu, Xinli Song, Jinfang Luo, Hong Yang, Xiaolan Chen, Xingde Liu   +7 more
doaj   +1 more source

Improved Pharmacokinetic Feasibilities of Mirabegron-1,2-Ethanedisulfonic Acid, Mirabegron-1,5-Naphthalenedisulfonic Acid, and Mirabegron-L-Pyroglutamic Acid as Co-Amorphous Dispersions in Rats and Mice

Pharmaceutics, 2023
Mirabegron (MBR) is a β3-adrenoceptor agonist used for treating overactive bladder syndrome. Due to its poor solubility and low bioavailability (F), the development of novel MBR formulations has garnered increasing attention.
Seo-Yeon Kim, Byung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung, Young Hee Choi   +5 more
doaj   +1 more source

Analysis of the Distribution of Total Phosphine and the Characteristics of Phosphine Poisoning in 29 Victims

Fayixue Zazhi, 2022
ObjectiveTo study the distribution of total phosphine in phosphine poisoning victims and summarize the characteristics of phosphine poisoning cases.MethodsThe phosphine and its metabolites in the biological samples of 29 victims in 16 phosphine poisoning
YAN Hui, DU Meng, QIAO Zheng, XIANG Ping, SHEN Bao-hua, SHEN Min, LIU Wei   +6 more
doaj   +1 more source

Distribution of norovirus in oyster tissues [PDF]

Journal of Applied Microbiology, 2008
To study the distribution of norovirus (NV) in oyster tissues.Five monoclonal antibodies (MAbs) against VP1 were selected from Balb/c mice. Immunohistochemical analysis was performed to detect native NV in different tissues of artificially contaminated oysters using the MAbs. The data showed that the gills and the digestive glands are efficient tissues
Dapeng, Wang, Qingping, Wu, Xiaoxia, Kou, Lin, Yao, Jumei, Zhang   +4 more
openaire   +2 more sources

Distribution of Micro-Nano PS, DEHP, and/or MEHP in Mice and Nerve Cell Models In Vitro after Exposure to Micro-Nano PS and DEHP

Toxics, 2023
Polystyrene (PS) and di-(2-ethylhexyl) phthalate (DEHP) exist widely in the environment. However, their distribution in organisms remains unclear. We used three sizes (50 nm, 500 nm, and 5 μm) of PS and DEHP to study the distribution and accumulation of ...
Jie Han, Jun Yan, Kang Li, Bencheng Lin, Wenqing Lai, Liping Bian, Rui Jia, Xiaohua Liu, Zhuge Xi   +8 more
doaj   +1 more source

Tissue and subcellular distribution of CLIC1 [PDF]

BMC Cell Biology, 2007
Abstract Background CLIC1 is a chloride channel whose cellular role remains uncertain. The distribution of CLIC1 in normal tissues is largely unknown and conflicting data have been reported regarding the cellular membrane fraction in which CLIC1 resides.
Edwards John C, Woost Philip G, Bruno Jonathan, Ulmasov Barbara   +3 more
openaire   +3 more sources