Results 11 to 20 of about 3,009,910 (332)

Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models [PDF]

, 2020
Natural tissues are incorporated with vasculature, which is further integrated with a cardiovascular system responsible for driving perfusion of nutrient‐rich oxygenated blood through the vasculature to support cell metabolism within most cell‐dense ...
Bonewald, Lynda F., Ekser, Burcin, Li, Ping, McCarthy, Brian Paul, Prideaux, Matthew, Sego, T. J., Smith, Lester Jeshua, Sterner, Jane, Tovar, Andres   +8 more
core   +1 more source

A Pyridazinone Compound for Effectively Treating Non-alcoholic Steatohepatitis by Targeting THRβ

Frontiers in Chemistry, 2022
Developing effective therapies and medicines to conquer nonalcoholic steatohepatitis (NASH) is of great significance for public health and is faced with a major challenge.
Hao Cheng, Hao Cheng, Hao Cheng, Hao Cheng, Xiao-Bo Wang, Xiao-Bo Wang, Ying Zhi, Ying Zhi, Ying Zhi, Ying Zhi, Bo Liu, Bo Liu, Bo Liu, Bo Liu, Na Liu, Meng-Jun Li, Yan-Ling Mu, Yan-Ling Mu, Yan-Ling Mu, Yan-Ling Mu   +19 more
doaj   +1 more source

Effects of Huangqi Liuyi Decoction in the Treatment of Diabetic Nephropathy and Tissue Distribution Difference of its Six Active Constituents Between Normal and Diabetic Nephropathy Mouse Models

Frontiers in Pharmacology, 2022
The purpose of this study was to investigate the effects of Huangqi Liuyi decoction extract (HQD) on diabetic nephropathy (DN), and the tissue distribution difference of six main active ingredients of HQD between normal and DN mouse models.
Qun Wang, Ya Shi, Zengguang Wu, Xinli Song, Jinfang Luo, Hong Yang, Xiaolan Chen, Xingde Liu   +7 more
doaj   +1 more source

Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle - An efficacy study in the hamster [PDF]

, 2002
The development of hemoglobin-based oxygen carriers has been propagated for replacement of the oxygen carrying properties of red blood cells for almost one century.
Botzlar, Andreas, Nolte, Dirk, Steinhauser, Peter   +2 more
core   +1 more source

Improved Pharmacokinetic Feasibilities of Mirabegron-1,2-Ethanedisulfonic Acid, Mirabegron-1,5-Naphthalenedisulfonic Acid, and Mirabegron-L-Pyroglutamic Acid as Co-Amorphous Dispersions in Rats and Mice

Pharmaceutics, 2023
Mirabegron (MBR) is a β3-adrenoceptor agonist used for treating overactive bladder syndrome. Due to its poor solubility and low bioavailability (F), the development of novel MBR formulations has garnered increasing attention.
Seo-Yeon Kim, Byung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung, Young Hee Choi   +5 more
doaj   +1 more source

Microvascular and tissue oxygen distribution [PDF]

Cardiovascular Research, 1996
Understanding of oxygen delivery by the microcirculation has been dominated by the unitary component analysis of Krogh and Erlangen focussed on oxygen transport mediated by single capillaries, oxygenation of tissue as a whole being extrapolated from findings on oxygen exchange in these vessels.
Marcos Intaglietta, Robert M. Winslow, Paul C. Johnson   +2 more
openaire   +2 more sources

Quantitative analysis of cell types during growth and morphogenesis in Hydra [PDF]

, 1973
Tissue maceration was used to determine the absolute number and the distribution of cell types in Hydra. It was shown that the total number of cells per animal as well as the distribution of cells vary depending on temperature, feeding conditions, and ...
A. Gierer, A. L. Burnett, C. N. David, C. N. David, E. Trenkner, G. Webster, H. Bode, H. K. MacWilliams, H. Schaller, J. J. Kanaev, L. Wolpert, P. Tardent, P. Tardent, R. D. Campbell, S. Berking, T. L. Lentz, W. F. Loomis   +16 more
core   +1 more source

Analysis of the Distribution of Total Phosphine and the Characteristics of Phosphine Poisoning in 29 Victims

Fayixue Zazhi, 2022
ObjectiveTo study the distribution of total phosphine in phosphine poisoning victims and summarize the characteristics of phosphine poisoning cases.MethodsThe phosphine and its metabolites in the biological samples of 29 victims in 16 phosphine poisoning
YAN Hui, DU Meng, QIAO Zheng, XIANG Ping, SHEN Bao-hua, SHEN Min, LIU Wei   +6 more
doaj   +1 more source

Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats\ud [PDF]

, 2011
Aims: To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications.
Jong, Wim H. de, Krystek, Petra, Lankveld, Danielle P.K., Leeuwen, Ton G. van, Manohar, Srirang, Oomen, Agnes G., Rayavarapu, Raja G., Verharen, Hennie W.   +7 more
core   +8 more sources

Distribution of Micro-Nano PS, DEHP, and/or MEHP in Mice and Nerve Cell Models In Vitro after Exposure to Micro-Nano PS and DEHP

Toxics, 2023
Polystyrene (PS) and di-(2-ethylhexyl) phthalate (DEHP) exist widely in the environment. However, their distribution in organisms remains unclear. We used three sizes (50 nm, 500 nm, and 5 μm) of PS and DEHP to study the distribution and accumulation of ...
Jie Han, Jun Yan, Kang Li, Bencheng Lin, Wenqing Lai, Liping Bian, Rui Jia, Xiaohua Liu, Zhuge Xi   +8 more
doaj   +1 more source