Results 71 to 80 of about 3,009,910 (332)

Distribution of Myrosinase in Rapeseed Tissues [PDF]

open access: yesPlant Physiology, 1991
Immunocytochemical studies on Brassica napus (rapeseed) tissues using a monoclonal antibody against myrosinase (thioglucoside glucohydrolase) showed that the enzyme was only present in a small number of cells. In the developing embryo, scattered myrosinase-containing cells were present in both cotyledons and axis.
Anders Falk   +3 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

A Use of Tritium-Labeled Peat Fulvic Acids and Polyphenolic Derivatives for Designing Pharmacokinetic Experiments on Mice

open access: yesBiomedicines, 2021
Natural products (e.g., polyphenols) have been used as biologically active compounds for centuries. Still, the mechanisms of biological activity of these multicomponent systems are poorly understood due to a lack of appropriate experimental techniques ...
Gennady A. Badun   +9 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Tissue Distribution of Lipoprotein Lipase (LPL) and Regulation of LPL Gene Expression Induced by Insulin and Glucose in Goose Primary Hepatocytes

open access: yesThe Journal of Poultry Science, 2010
The study was to research the gene expression of lipoprotein lipase (LPL) in abdomen adipose tissue, subcutaneous adipose tissue, pectoral muscle, skeletal muscles, liver, brain and spleen of geese, and the effect of insulin and glucose on gene ...
Chunchun Han   +5 more
doaj   +1 more source

Bone Graft Packing and Its Association with Bone Regeneration in Maxillary Sinus Floor Augmentations: Histomorphometric Analysis of Human Biopsies

open access: yesBiology, 2022
Research in maxillary sinus floor augmentation (MSFA) focussed on the optimisation of microstructural parameters such as microporosity and particle size of bone substitute particles (BS).
Karoline Maria Reich   +6 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Postmortem tissue distribution of morphine and its metabolites in a series of heroin related deaths [PDF]

open access: yes, 2018
The abuse of heroin (diamorphine) and heroin deaths are growing around the world. The interpretation of the toxicological results from suspected heroin deaths is notoriously difficult especially in cases where there may be limited samples.
Beer, Lewis J.   +6 more
core   +5 more sources

Plasma Bead Entrapped Liposomes as a Potential Drug Delivery System to Combat Fungal Infections

open access: yesMolecules, 2022
Fibrin-based systems offer promises in drug and gene delivery as well as tissue engineering. We established earlier a fibrin-based plasma beads (PB) system as an efficient carrier of drugs and antigens.
Munazza Tamkeen Fatima   +4 more
doaj   +1 more source

PEPTIDASE DISTRIBUTION IN LYMPHATIC TISSUE [PDF]

open access: yesThe Journal of Cell Biology, 1955
The lymphatic tissue of the rabbit contains a labile peptidase as measured by the hydrolysis of alanylglycine. Some characteristics of the enzyme were determined. This enzyme increases in amount when the numbers of macrophages in the tissue are increased and it is also present in the extracellular fluid in high concentration.
openaire   +3 more sources

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