Results 11 to 20 of about 18,027,656 (296)

Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?

Emerging Microbes and Infections, 2020
We previously made the hypothesis that STING contributes to COVID-19. The present review detail new arguments for over-activation of STING pathways in COVID-19, following the description of hyper-coagulability and Kawasaki-like diseases in children ...
Jean-Marie Berthelot, Ludovic Drouet, Frédéric Lioté   +2 more
doaj   +1 more source

A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
In 2021, pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer deaths in the United States. This is largely due to a lack of symptoms and limited treatment options, which extend survival by only a few weeks.
Clayton S. Lewis, Aniruddha Karve, Kateryna Matiash, Timothy Stone, Jingxing Li, Jordon K. Wang, Henri H. Versteeg, Bruce J. Aronow, Syed A. Ahmad, Pankaj B. Desai, Vladimir Y. Bogdanov   +10 more
doaj   +1 more source

Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury

Frontiers in Cellular and Infection Microbiology, 2021
BackgroundPatients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported.
Hao Zhang, Hao Zhang, Yilu Zhou, Mengdi Qu, Mengdi Qu, Ying Yu, Ying Yu, Zhaoyuan Chen, Zhaoyuan Chen, Shuainan Zhu, Shuainan Zhu, Kefang Guo, Kefang Guo, Wankun Chen, Wankun Chen, Changhong Miao, Changhong Miao   +16 more
doaj   +1 more source

Endothelial dysfunction and immunothrombosis in sepsis

Frontiers in Immunology, 2023
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction caused by a dysregulated or over-reactive host response to infection.
Eleni Maneta, Evmorfia Aivalioti, Simon Tual-Chalot, Besa Emini Veseli, Aikaterini Gatsiou, Kimon Stamatelopoulos, Kimon Stamatelopoulos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos   +10 more
doaj   +1 more source

Transforming growth factor–β in tissue fibrosis

Journal of Experimental Medicine, 2020
TGF-β is a central mediator in the fibrotic response. This review discusses the role of TGF-β in tissue fibrosis, highlighting the mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic ...
N. Frangogiannis
semanticscholar   +1 more source

Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis

Seminars in Thrombosis and Hemostasis, 2019
There is a strong relationship between tissue factor (TF) and cancer. Many cancer cells express high levels of both full-length TF and alternatively spliced (as) TF. TF expression in cancer is associated with poor prognosis.
Y. Hisada, N. Mackman
semanticscholar   +1 more source

Tissue factor at the crossroad of coagulation and cell signaling

Journal of Thrombosis and Haemostasis, 2018
The tissue factor (TF) pathway plays a central role in hemostasis and thrombo‐inflammatory diseases. Although structure‐function relationships of the TF initiation complex are elucidated, new facets of the dynamic regulation of TF's activities in cells ...
H. Zelaya, H. Zelaya, A. Rothmeier, W. Ruf, W. Ruf   +4 more
semanticscholar   +1 more source

Different Potential of Extracellular Vesicles to Support Thrombin Generation: Contributions of Phosphatidylserine, Tissue Factor, and Cellular Origin

Scientific Reports, 2017
Cells release diverse types of vesicles constitutively or in response to proliferation, injury, inflammation, or stress. Extracellular vesicles (EVs) are crucial in intercellular communication, and there is emerging evidence for their roles in ...
C. Tripisciano, R. Weiss, Tanja Eichhorn, A. Spittler, T. Heuser, M. Fischer, V. Weber   +6 more
semanticscholar   +1 more source

Detection of tissue factor in platelets: why is it so troublesome?

Platelets, 2019
Tissue factor (TF) is the most important trigger for the extrinsic coagulation pathway. TF, earlier denoted as thromboplastin, has always been a mystery since its discovery due to its abundant presence in most human tissues but not blood.
Bjarne Østerud, Beth A. Bouchard
doaj   +1 more source

Vitamin D Inhibits IL-6 Pro-Atherothrombotic Effects in Human Endothelial Cells: A Potential Mechanism for Protection against COVID-19 Infection?

Journal of Cardiovascular Development and Disease, 2022
Background: Thrombosis with cardiovascular involvement is a crucial complication in COVID-19 infection. COVID-19 infects the host by the angiotensin converting enzyme-2 receptor (ACE2r), which is expressed in endothelial cells too.
Giovanni Cimmino, Stefano Conte, Mariarosaria Morello, Grazia Pellegrino, Laura Marra, Andrea Morello, Giuseppe Nicoletti, Gennaro De Rosa, Paolo Golino, Plinio Cirillo   +9 more
doaj   +1 more source