Results 31 to 40 of about 2,653,429 (308)
Biomolecules, 2021 The vast majority of coagulation factor VII (FVII), a trypsin-like protease, circulates as the inactive zymogen. Activated FVII (FVIIa) is formed upon proteolytic activation of FVII, where it remains in a zymogen-like state and it is fully activated only
Jesper J. Madsen, Ole H. Olsen
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Frontiers in Physiology, 2018 Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention of uremic toxins, especially indoxyl sulfate
Malgorzata Karbowska +9 more
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Cell Adhesion & Migration, 2021 Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human ...
Yanling Jin +9 more
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Molecules, 2023 Chuanxiong rhizoma (CX) has been utilized for centuries as a traditional herb to treat blood stasis syndromes. However, the pharmacological mechanisms are still not completely revealed.
Shasha He +3 more
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Tissue Factor–Factor VIIa Signaling [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes? One of the answers is that TF interaction with FVIIa not only initiates clotting but also induces cell signaling via activation of G-protein–coupled protease activated receptors
L Vijaya Mohan, Rao, Usha R, Pendurthi
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Inhibitors of Factor VIIa/Tissue Factor [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 The formation of the proteolytic complex composed of the serine protease Factor VIIa and the cell-associated glycoprotein tissue factor (FVIIa/TF) initiates a cascade of amplified zymogen activation reactions leading to thrombus formation. The critical role of the coagulation cascade in pathological thrombosis has been the basis for significant efforts
Rebecca A, Shirk, George P, Vlasuk
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Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]
, 2005 We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Beattie, J +19 more
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Tissue factor: mechanisms of decryption [PDF]
Frontiers in Bioscience, 2012 It is generally believed that only a small fraction of the tissue factor (TF) found on cell surfaces is active whereas the vast majority is cryptic in coagulation. It is unclear how cryptic TF differs from the coagulant active TF or potential mechanisms involved in transformation of cryptic TF to the coagulant active form.
L Vijaya Mohan, Rao +2 more
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Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood
, 2007 Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann, Matthias +11 more
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Artificial neural networks in hard tissue engineering : another look at age-dependence of trabecular bone properties in osteoarthritis [PDF]
, 2014 Artificial Neural Network (ANN) model has been developed to correlate age of severely osteoarthritic male and female specimens with key mechanical and structural characteristics of their trabecular bone.
Natasha A Khovanova +5 more
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