Results 31 to 40 of about 8,614,068 (306)

Heparanase and Coagulation–New Insights

Rambam Maimonides Medical Journal, 2014
Heparanase, a β-D-endoglucuronidase abundant in platelets that was discovered 30 years ago, is an enzyme that cleaves heparan sulfate side chains on the cell surface and in the extracellular matrix. It was later recognized as being a pro-inflammatory and
Yona Nadir
doaj   +1 more source

Decryption of tissue factor [PDF]

Thrombosis Research, 2012
Tissue factor (TF) is a transmembrane protein which, in complex with factor (F)VIIa, initiates blood coagulation. Numerous studies have determined TF epitopes and individual amino acids which play an important role in the TF/FVIIa complex formation and its activity towards natural substrates.
Saulius, Butenas, Jolanta, Krudysz-Amblo
openaire   +2 more sources

Tissue factor and cancer [PDF]

Thrombosis Research, 2012
The hemostatic system is involved in multiple interactions with transformed cells that progress from a dormant, non-vascularized tumor to highly metastatic phenotypes. Oncogenic transformations up regulate not only the initiator of the coagulation cascade, tissue factor (TF), but also induce other molecules that are required for TF's direct cell ...
openaire   +2 more sources

Heparanase—A Link between Coagulation, Angiogenesis, and Cancer

Rambam Maimonides Medical Journal, 2012
Heparanase that was cloned from and is abundant in the placenta is implicated in cell invasion, tumor metastasis, and angiogenesis. Recently we have demonstrated that heparanase may also affect the hemostatic system in a non-enzymatic manner.
Yona Nadir, Benjamin Brenner
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Macrophage IL-1β-positive microvesicles exhibit thrombo-inflammatory properties and are detectable in patients with active juvenile idiopathic arthritis

Frontiers in Immunology, 2023
ObjectiveIL-1β is a leaderless cytokine with poorly known secretory mechanisms that is barely detectable in serum of patients, including those with an IL-1β-mediated disease such as systemic juvenile idiopathic arthritis (sJIA).
Audrey Cambon, Audrey Cambon, Charlotte Rebelle, Charlotte Rebelle, Richard Bachelier, Laurent Arnaud, Stéphane Robert, Marie Lagarde, Romain Muller, Romain Muller, Edwige Tellier, Yéter Kara, Aurélie Leroyer, Catherine Farnarier, Loris Vallier, Corinne Chareyre, Karine Retornaz, Anne-Laure Jurquet, Tu-Anh Tran, Romaric Lacroix, Romaric Lacroix, Françoise Dignat-George, Françoise Dignat-George, Gilles Kaplanski, Gilles Kaplanski   +24 more
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Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? [PDF]

, 2010
Background: Heterogeneity of vascular permeability has been suggested for the coronary system. Whereas arteriolar and capillary segments are tight, plasma proteins pass readily into the interstitial space at venular sites.
Welsch, Ulrich, Peter Conzen, Bruegger, Dirk, Jacob, Matthias, Ingo Kaczmarek, Kaczmarek, Ingo, Conzen, Peter, Becker, Bernhard F., Stoeckelhuber, Mechthild, Rehm, Markus, Daniel Chappell, Dirk Bruegger, Chappell, Daniel, Bernhard F. Becker, Markus Rehm, Matthias Jacob, Ulrich Welsch, Mechthild Stoeckelhuber   +17 more
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Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: a Prospective Pilot Study

Frontiers in Medicine, 2016
Introduction: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. Our aim was to
Agnese Ozolina, Agnese Ozolina, Marina Sarkele, Marina Sarkele, Olegs Sabelnikovs, Olegs Sabelnikovs, Andrejs Skesters, Inta Jaunalksne, Jelena Serova, Talis Ievins, Lars Jakob Bjertnæs, Indulis Vanags, Indulis Vanags   +12 more
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Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain

Biomolecules, 2021
The vast majority of coagulation factor VII (FVII), a trypsin-like protease, circulates as the inactive zymogen. Activated FVII (FVIIa) is formed upon proteolytic activation of FVII, where it remains in a zymogen-like state and it is fully activated only
Jesper J. Madsen, Ole H. Olsen
doaj   +1 more source

Angiogenesis in tissue engineering : Breathing life into constructed tissue substitutes [PDF]

, 2006
Long-term function of three-dimensional (3D) tissue constructs depends on adequate vascularization after implantation. Accordingly, research in tissue engineering has focused on the analysis of angiogenesis.
Germann, Gunter, Rücker, Martin, Haeufel, Joerg M., Torio-Padron, Nestor, Ruecker, Martin, Carvalho, Carlos, Heberer, Michael, Junker, Dominic, Häufel, Jörg M., Ring, Andrej, Amon, Michaela, Farhadi, Jian, Menger, Michael D., Vollmar, Brigitte, Laschke, Matthias W., Martin, Ivan, Harder, Yves, Schramm, Rene   +17 more
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Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3

Frontiers in Physiology, 2018
Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention of uremic toxins, especially indoxyl sulfate
Malgorzata Karbowska, Tomasz W. Kaminski, Beata Znorko, Tomasz Domaniewski, Tomasz Misztal, Tomasz Rusak, Anna Pryczynicz, Katarzyna Guzinska-Ustymowicz, Krystyna Pawlak, Dariusz Pawlak   +9 more
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