Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch +7 more
doaj +2 more sources
Comparative ex vivo analysis of Mim8 in thrombin generation assays triggered by activated factor XI or tissue factor [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Mim8 is a next-generation activated factor (F)VIII–mimetic, bispecific antibody, currently in clinical development for the prophylactic treatment of hemophilia A.
Wan Hui Ong Clausen +4 more
doaj +2 more sources
Thrombogenic and Inflammatory Reactions to Biomaterials in Medical Devices
Frontiers in Bioengineering and Biotechnology, 2020 Blood-contacting medical devices of different biomaterials are often used to treat various cardiovascular diseases. Thrombus formation is a common cause of failure of cardiovascular devices.
Carlos A. Labarrere +2 more
doaj +1 more source
Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia [PDF]
, 2006 Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth ...
Aicher, A +5 more
core +1 more source
Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression [PDF]
, 2016 BackgroundDespite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.MethodsIn this study the upregulation of TF release upon ...
A Bharthuar +57 more
core +2 more sources
Growth factor releasing scaffolds for cartilage tissue engineering [PDF]
, 2006 Over the last century, life expectancy has increased at a rapid pace resulting in an increase of articular cartilage disorders. To solve this problem, extensive research is currently performed using tissue engineering approaches.
Sohier, Jerome
core +8 more sources
Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? [PDF]
, 2010 Background: Heterogeneity of vascular permeability has been suggested for the coronary system. Whereas arteriolar and capillary segments are tight, plasma proteins pass readily into the interstitial space at venular sites.
Becker, Bernhard F. +8 more
core +1 more source
Tissue factor and cancer [PDF]
Thrombosis Research, 2012 The hemostatic system is involved in multiple interactions with transformed cells that progress from a dormant, non-vascularized tumor to highly metastatic phenotypes. Oncogenic transformations up regulate not only the initiator of the coagulation cascade, tissue factor (TF), but also induce other molecules that are required for TF's direct cell ...
openaire +2 more sources
Thrombosis Journal, 2005 Background Thrombin generation assay was developed several years ago to mimic physiological coagulation mechanisms but it had important limitations. Thrombogram-Thrombinoscope assay using a fluorogenic substrate, allows obtaining thrombin generation ...
Leflem Lena +5 more
doaj +1 more source
Comparison of the coagulopathies associated with COVID‐19 and sepsis
Research and Practice in Thrombosis and Haemostasis, 2021 Background Coronavirus disease 2019 (COVID‐19) is associated with activation of coagulation that mainly presents as thrombosis. Sepsis is also associated with activation of coagulation that mainly presents as disseminated intravascular coagulation.
Robert A. Campbell +8 more
doaj +1 more source