Results 11 to 20 of about 8,614,068 (306)

Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch, Georg F. Lehner, Clemens Feistritzer, Andreas Peer, Birgit Zassler, Viktoria M. Neumair, Sebastian J. Klein, Michael Joannidis   +7 more
doaj   +2 more sources

Tanshinone IIA inhibits malignant progression in a spontaneous breast cancer mouse model by attenuating tissue factor-mediated angiogenesis [PDF]

Frontiers in Pharmacology
IntroductionAs a classic botanical drug, Salvia miltiorrhiza Bunge has long been used to promote blood circulation and remove blood stasis. Tanshinone IIA (Tan IIA), a major bioactive diterpenoid derived from its roots, shows promising therapeutic ...
Yuan Wang, Xiaoyue Yan, Zheng Wang, Ye Sun, Ziyan Zhu, Ting Mao, Quanyue Wang, Xiaofeng Fan, Xinyu Lu, Junde Xu, Xiaoman Li, Yin Lu, Yin Lu, Yuanyuan Wu   +13 more
doaj   +2 more sources

Local hemostasis disorders underlying endometric pathology

Акушерство, гинекология и репродукция, 2021
Introduction. Hemostasis is an equilibrium system that performs 2 bidirectional tasks: on the one hand, it prevents bleeding development, whereas on the other hand, it counters thrombogenesis.
E. Iu. Iupatov, I. G. Mustafin, T. E. Kurmanbaev, R. M. Nabiullina, K. M. Atayants, A. A. Shmidt, E. V. Frederiks   +6 more
doaj   +1 more source

Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells

Immunity, Inflammation and Disease, 2023
Background Vascular diseases are highly associated with inflammation and thrombosis. Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more effective treatments. The activation
Christopher T. Freda, Wei Yin, Berhane Ghebrehiwet, David A. Rubenstein   +3 more
doaj   +1 more source

Tissue factor and tissue factor pathway inhibitor [PDF]

Anaesthesia, 2004
Summary The classical ‘cascade/waterfall’ hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways.
G C, Price, S A, Thompson, P C A, Kam
openaire   +2 more sources

Endothelial dysfunction and immunothrombosis in sepsis

Frontiers in Immunology, 2023
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction caused by a dysregulated or over-reactive host response to infection.
Eleni Maneta, Evmorfia Aivalioti, Simon Tual-Chalot, Besa Emini Veseli, Aikaterini Gatsiou, Kimon Stamatelopoulos, Kimon Stamatelopoulos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos, Konstantinos Stellos   +10 more
doaj   +1 more source

A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
In 2021, pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer deaths in the United States. This is largely due to a lack of symptoms and limited treatment options, which extend survival by only a few weeks.
Clayton S. Lewis, Aniruddha Karve, Kateryna Matiash, Timothy Stone, Jingxing Li, Jordon K. Wang, Henri H. Versteeg, Bruce J. Aronow, Syed A. Ahmad, Pankaj B. Desai, Vladimir Y. Bogdanov   +10 more
doaj   +1 more source

Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury

Frontiers in Cellular and Infection Microbiology, 2021
BackgroundPatients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported.
Hao Zhang, Hao Zhang, Yilu Zhou, Mengdi Qu, Mengdi Qu, Ying Yu, Ying Yu, Zhaoyuan Chen, Zhaoyuan Chen, Shuainan Zhu, Shuainan Zhu, Kefang Guo, Kefang Guo, Wankun Chen, Wankun Chen, Changhong Miao, Changhong Miao   +16 more
doaj   +1 more source

Value of multimodal MRI in evaluation of tissue factor expression in glioblastoma

Di-san junyi daxue xuebao, 2020
Objective To explore the correlation between multimodal magnetic resonance imaging (MRI) and expression of tissue factor (TF) in glioblastoma (GBM), and investigate the values of MRI parameters as imaging markers for TF.
ZHOU Bo, TONG Haipeng, CHEN Xiao, XUE Wei, XU Kai, ZHANG Weiguo   +5 more
doaj   +1 more source

Potential biochemical markers of chronic bronchitis

Бюллетень сибирской медицины, 2021
The review systematizes modern data on the biochemical markers that can clarify the nature and the course of chronic bronchitis. The article describes markers associated with bronchopulmonary pathology, such as tumor necrosis factor alpha (TNFα ...
E. A. Kurtukov, Yu. I. Ragino
doaj   +1 more source