Results 231 to 240 of about 18,027,656 (296)

Preclinical Characterization of XB002, an Anti-Tissue Factor Antibody-Drug Conjugate for the Treatment of Solid Tumors. [PDF]

Mol Cancer Ther
Kantak S, Faggioni R, Cai AG, Bhatti MM, Li J, Vainshtein I, Cheng J, Mendelsohn BA, Gaudreault J, Migone TS, Theunissen JW.   +10 more
europepmc   +1 more source

Blood-borne tissue factor: another view of thrombosis.

Proceedings of the National Academy of Sciences of the United States of America, 1999
P. Giesen, U. Rauch, B. Bohrmann, D. Kling, M. Roqué, J. Fallon, J. Badimón, J. Himber, M. Riederer, Y. Nemerson   +9 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Tissue Factor Pathway Inhibitor 2 Enhances Hepatocellular Carcinoma Chemosensitivity by Activating CCAR2-GADD45A-Mediated DNA Damage Repair. [PDF]

Int J Biol Sci
Zhou H, Zhu L, Zhang Y, Chen L, Gou DM, Zhang H, Hua R, Song J, Qiu C, Yao FW, Wei X, Gu D, Xu Y.   +12 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Tissue factor pathway inhibitor levels and atherothrombotic events in patients with chronic kidney disease or diabetes. [PDF]

J Thromb Thrombolysis
Brook R, Suleiman M, Rigano J, Lui B, Nandurkar H, Ho P, Lim HY.   +6 more
europepmc   +1 more source

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

Proceedings of the National Academy of Sciences of the United States of America, 2001
G. Nicolas, M. Bennoun, I. Devaux, C. Beaumont, B. Grandchamp, A. Kahn, S. Vaulont   +6 more
semanticscholar   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Tissue factor targeted near-infrared photoimmunotherapy: a versatile therapeutic approach for malignancies. [PDF]

Cancer Immunol Immunother
Takao S, Fukushima H, Furusawa A, Kato T, Okuyama S, Kano M, Yamamoto H, Suzuki M, Kano M, Choyke PL, Kobayashi H.   +10 more
europepmc   +1 more source

Environments of the four tryptophans in the extracellular domain of human tissue factor: comparison of results from absorption and fluorescence difference spectra of tryptophan replacement mutants with the crystal structure of the wild-type protein

, 1995
C. A. Hasselbacher, E. V. Rusinova, Eli Waxman, Radda Rusinova, Ronald A. Kohanski, Wan Yee Lam, Anirban Guha, Jiangfeng Du, Tai‐Shun Lin, Igor Polikarpov   +9 more
openalex   +1 more source