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Pathophysiology of Haemostasis and Thrombosis, 2007
Tissue factor (TF), the key regulator of haemostasis and angiogenesis, is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions. In the latter, TF is upregulated by cancer cells, as well as by certain host cells, and it is the interactions between these distinct pools of TF-expressing cells
Chloe, Milsom, Janusz, Rak
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Tissue factor (TF), the key regulator of haemostasis and angiogenesis, is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions. In the latter, TF is upregulated by cancer cells, as well as by certain host cells, and it is the interactions between these distinct pools of TF-expressing cells
Chloe, Milsom, Janusz, Rak
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Seminars in Thrombosis and Hemostasis, 2006
Tissue factor (TF) exhibits a distinct nonuniform tissue distribution. Thus, high levels are found in highly vascularized organs such as the lung, brain, and placenta; intermediate levels in the heart, kidney, intestine, testes, and uterus; and low levels in the spleen, thymus, and liver.
Bjarne, Østerud, Eirik, Bjørklid
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Tissue factor (TF) exhibits a distinct nonuniform tissue distribution. Thus, high levels are found in highly vascularized organs such as the lung, brain, and placenta; intermediate levels in the heart, kidney, intestine, testes, and uterus; and low levels in the spleen, thymus, and liver.
Bjarne, Østerud, Eirik, Bjørklid
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Tissue factor in atherosclerosis
Atherosclerosis, 1999Thrombosis is a key feature of the initiation and progression of atherosclerosis and its clinical sequelae. Acute thrombosis can lead to arterial occlusion and consequently provoke myocardial infarction, unstable angina, stroke and sudden death. Acute thrombosis can also be a complication of arterial bypass surgery, balloon angioplasty, atherectomy, or
E. Tremoli +3 more
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Current Opinion in Hematology, 2008
Tissue factor is increasingly viewed as an integral part of the vicious circle that links the vascular system with cancer progression at multiple systemic, cellular and molecular levels.The emerging tenet in this area is that oncogenic events/pathways driving the malignant process also stimulate the expression of tissue factor by cancer cells and ...
Janusz, Rak, Chloe, Milsom, Joanne, Yu
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Tissue factor is increasingly viewed as an integral part of the vicious circle that links the vascular system with cancer progression at multiple systemic, cellular and molecular levels.The emerging tenet in this area is that oncogenic events/pathways driving the malignant process also stimulate the expression of tissue factor by cancer cells and ...
Janusz, Rak, Chloe, Milsom, Joanne, Yu
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Best Practice & Research Clinical Haematology, 1999
Blood coagulation is initiated in response to vessel damage in order to preserve the integrity of the mammalian vascular system. The coagulation cascade can also be initiated by mediators of the inflammatory response, and fibrin deposition has been noted in a variety of pathological states.
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Blood coagulation is initiated in response to vessel damage in order to preserve the integrity of the mammalian vascular system. The coagulation cascade can also be initiated by mediators of the inflammatory response, and fibrin deposition has been noted in a variety of pathological states.
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Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor
Journal of Thrombosis and Thrombolysis, 2012Preeclampsia (PE) is a multi-system disorder of human pregnancy, whose etiology remains poorly understood. Preeclamptic women are known to have an increased hypercoagulable state that result in excess fibrin deposition in several organs, which compromises their function.
Godoi, Lara Carvalho +5 more
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Tissue Factor and Tissue Factor Pathway Inhibitor in Hemodialysis Patients
The International Journal of Artificial Organs, 1998Tissue factor and tissue factor pathway inhibitor are important in extrinsic coagulation. We investigated their clinical significance in hemodialysis patients. We took blood samples, prior to initiation of routine hemodialysis, from 73 patients on hemodialysis (35 men and 38 women aged 56.1 ± 11.7 years on dialysis for 82.1 ± 61.0 months), and ...
N, Yorioka +6 more
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Kinetics of the Inhibition of Tissue Factor-Factor Vila by Tissue Factor Pathway Inhibitor
Thrombosis and Haemostasis, 1995SummaryTissue factor-factor VIIa catalysed activation of factor X and factor IX is inhibited by the complex of tissue factor pathway inhibitor (TFPI) and factor Xa. At present, no information is available as to what extent the kinetics of complex formation between TFPI and factor Xa during factor X activation contribute to the overall rate of ...
T, Lindhout, J, Franssen, G, Willems
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Thrombosis and Haemostasis, 1995
Much has been learned about tissue factor during the past 25 years and much is yet to be learned. On the biochemical level, the association of TF:VIIa with factor X is yet to be resolved. The mechanism by which TF is transported from the nucleus to the plasma membrane has yet to even be approached.
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Much has been learned about tissue factor during the past 25 years and much is yet to be learned. On the biochemical level, the association of TF:VIIa with factor X is yet to be resolved. The mechanism by which TF is transported from the nucleus to the plasma membrane has yet to even be approached.
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Thrombosis and Haemostasis, 2000
The issues raised by Osterud and his colleagues in a paper in this journal are important and interesting. To prove a negative, however, is not possible because it implies that the entire universe must be examined - obviously an impossible condition. Osterud and his coworkers investigated the synthesis of tissue factor in whole blood and concluded that ...
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The issues raised by Osterud and his colleagues in a paper in this journal are important and interesting. To prove a negative, however, is not possible because it implies that the entire universe must be examined - obviously an impossible condition. Osterud and his coworkers investigated the synthesis of tissue factor in whole blood and concluded that ...
openaire +2 more sources