Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy. [PDF]
J Thromb Haemost, 2022 Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that primarily dampens the initiation phase of coagulation before thrombin is generated. As such, TFPI’s actions are localized to cells expressing TF and to sites of
Mast AE, Ruf W.
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Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation [PDF]
Redox Biology, 2023 Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether endothelial cell-driven oxidative post-translational modifications could have an impact on TFPI ...
Janina Wittig +8 more
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A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet’s Syndrome [PDF]
Scientific Reports, 2016 Thrombosis is common in Behçet’s Syndrome (BS), and there is a need for better biomarkers for risk assessment. As microparticles expressing Tissue Factor (TF) can contribute to thrombosis in preclinical models, we investigated whether plasma ...
Emon Khan +10 more
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MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium [PDF]
Scientific Reports, 2022 A large portion of the genome is transcribed into non-coding RNA, which does not encode protein. Many long non-coding RNAs (lncRNAs) have been shown to be involved in important regulatory processes such as genomic imprinting and chromatin modification ...
Veerle Kremer +8 more
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Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch +7 more
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Associations of tissue factor and tissue factor pathway inhibitor with organ dysfunctions in septic shock [PDF]
Scientific ReportsCoagulopathy, microvascular alterations and concomitant organ dysfunctions are hallmarks of sepsis. Attempts to attenuate coagulation activation with an inhibitor of tissue factor (TF), i.e.
Georg Franz Lehner +9 more
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Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis.
Blood, 2019 Antiphospholipid antibodies (aPL) with complex lipid and/or protein reactivities cause complement-dependent thrombosis and pregnancy complications.
Müller-Calleja N +11 more
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Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia [PDF]
Scientific Reports, 2021 The infiltration of chronic lymphocytic leukemia (CLL) cells into lymphoid organs correlates with disease severity. CXCL12 is a key chemotactic factor for the trafficking of CLL.
Xue Yan Cui +11 more
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Tissue factor pathway inhibitor 2 (TFPI2) is a potential serum biomarker for clear cell renal carcinoma [PDF]
Scientific ReportsRenal and ovarian clear cell carcinoma (CCC) are both characterized by a clear cytoplasm and exhibit similar genomic alterations and clinical characteristics. We hypothesized that both CCCs may share clinical biomarker. Tissue factor pathway inhibitor 2 (
Hiroki Ito +12 more
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Critical Care Medicine, 2015 Objective:Bacterial DNA (CpG DNA) persists in tissues and blood under pathological conditions that are associated with enhanced intravascular coagulation. Toll-like receptor 9 recognizes CpG DNA and elicits innate and adoptive immunity, yet the impact of
Driss El Kebir +3 more
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