Results 211 to 220 of about 661,753 (260)

Tissue Factor Pathway Inhibitor: Then and Now

Seminars in Thrombosis and Hemostasis, 2014
Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation. TFPI inhibits the TF-activated factor VII (FVIIa) complex in an activated factor X (FXa)-dependent manner, helping to control thrombin generation and ultimately fibrin formation.
Ellery, P., Adams, M.
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Tissue Factor and Tissue Factor Pathway Inhibitor in Hemodialysis Patients

The International Journal of Artificial Organs, 1998
Tissue factor and tissue factor pathway inhibitor are important in extrinsic coagulation. We investigated their clinical significance in hemodialysis patients. We took blood samples, prior to initiation of routine hemodialysis, from 73 patients on hemodialysis (35 men and 38 women aged 56.1 ± 11.7 years on dialysis for 82.1 ± 61.0 months), and ...
N, Yorioka, Y, Taniguchi, K, Yamashita, C, Ueda, C, Nakamura, S, Harada, M, Yamakido   +6 more
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Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor

Journal of Thrombosis and Thrombolysis, 2012
Preeclampsia (PE) is a multi-system disorder of human pregnancy, whose etiology remains poorly understood. Preeclamptic women are known to have an increased hypercoagulable state that result in excess fibrin deposition in several organs, which compromises their function.
Godoi, Lara Carvalho, Gomes, Karina Braga, Alpoim, Patrícia Nessralla, Carvalho, Maria das Graças, Lwaleed, Bashir A., Sant’Ana Dusse, Luci Maria   +5 more
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Tissue factor pathway inhibitor.

Minerva medica, 1999
The role of Tissue Factor (TF, thromboplastin) as the major factor in initiation of the blood coagulation process has been known for more than 100 years. Its importance for the development of clinical thrombosis, be it venous or arterial, and the complexity of the cell biology of TF, have however been increasingly appreciated over the past 15-20 years.
CAMICI, MARCELLO, SAGRIPANTI A.
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Tissue Factor Pathway Inhibitor and Heparin

1992
The anticoagulant property of heparinized blood results from interactions between heparin, protease inhibitors and clotting enzymes. The inactivation of thrombin, factor Xa and factor IXa by antithrombin (AT) is dramatically accelerated by even low concentrations of heparin.
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The inhibitors of the tissue factor:factor VII pathway

Thrombosis Research, 2002
It is widely accepted that blood coagulation in vivo is initiated during normal hemostasis, as well as during intravascular thrombus formation, when the cell-surface protein, tissue factor (TF), is exposed to the blood as a consequence of vascular injury.
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Structure and Biology of Tissue Factor Pathway Inhibitor

Thrombosis and Haemostasis, 2001
SummaryHuman tissue factor pathway inhibitor (TFPI) is a modular protein comprised of three Kunitz type domains flanked by peptide segments that are less structured. The sequential order of the elements are: an N-terminal acidic region followed by the first Kunitz domain (K1), a linker region, a second Kunitz domain (K2), a second linker region, the ...
M S, Bajaj, J J, Birktoft, S A, Steer, S P, Bajaj   +3 more
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The present status of tissue factor pathway inhibitor

Blood Coagulation & Fibrinolysis, 1992
Tissue factor pathway inhibitor (TFPI) is the factor Xa-dependent inhibitor of the factor VIIa/tissue factor complex. The plasma concentration of this 276 amino acid, 40 kDa glycoprotein is normally about 100 ng/ml. There are three intravascular pools of TFPI: 50-90% is on the endothelium, 10-50% is in plasma and less than 2.5% is in platelets.
A K, Lindahl, P M, Sandset, U, Abildgaard   +2 more
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Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets

American Journal of Physiology-Heart and Circulatory Physiology, 2005
Oral estrogen treatment increases thrombotic risk. Tissue factor (TF), tissue factor pathway inhibitor (TFPI), and platelet interaction with leukocytes are important determinants of thrombogenesis. Therefore, the present study was designed to define and compare platelet TF and TFPI mRNA and adhesion protein expression in platelets derived from animals ...
Muthuvel, Jayachandran, Antonio, Sanzo, Whyte G, Owen, Virginia M, Miller   +3 more
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Tissue factor pathway inhibitor in health and disease

Trends in Cardiovascular Medicine, 1995
The knowledge of tissue factor pathway inhibitor (TFPI) has greatly expanded during the last few years, and TFPI is now established as a coagulation inhibitor of great importance. Its main role seems to be inhibition of small amounts of tissue factor, which probably is essential for maintaining a normal hemostatic balance.
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