Results 131 to 140 of about 174,743 (266)
Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. [PDF]
, 2018 BackgroundComplications after injury, such as acute respiratory distress syndrome (ARDS), are common after traumatic brain injury (TBI) and associated with poor clinical outcomes.
Calfee, Carolyn S +8 more
core
ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]
, 2008 ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald +2 more
core +1 more source
Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics
Advanced Healthcare Materials, EarlyView.A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins +3 more
wiley +1 more source
Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]
, 2015 Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad +3 more
wiley +1 more source
Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy [PDF]
, 2018 Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by ...
Díaz Manera, Jordi +6 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez +8 more
wiley +1 more source
Egyptian Journal of Chest Disease and Tuberculosis, 2012 Background: Airway inflammation and remodeling of extracellular matrix are important features of asthma. Matrix metalloproteinases (MMPs) are group of enzymes expressed in the airways with their inhibitor (tissue inhibitor of MMPs (TIMP) and they are the
Ghada Mahmoud Mohamed +2 more
doaj +1 more source
World Journal of Gastroenterology, 2003 AIM The expressive balance between matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor of metalloproteinase-1 (TIMP-1) plays a critical role in maintaining the degradation and synthesis of extracellular matrix.
S. Zhang, Li Li, Jian-yin Lin, Hua Lin
semanticscholar +1 more source
Pathogenesis of chronic obstructive pulmonary disease [PDF]
, 2005 The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core +2 more sources