Results 71 to 80 of about 92,606 (252)
Egyptian Journal of Chest Disease and Tuberculosis, 2015 Cigarette smoking has a destructive effect on the extracellular matrix (ECM), so it is considered the most important risk factor for the development of emphysema as it leads to recruitment of activated macrophages and neutrophils in the lung leading to ...
Ali M. Abdella +4 more
doaj +1 more source
Associations of matrix metalloproteinase (MMP)-8, MMP-9, and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys [PDF]
Korean Journal of Pediatrics, 2014 PurposeMatrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults.
Youn Ho Shin +5 more
doaj +1 more source
Tuberculosis and Respiratory Diseases, 2005 Background : The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions.
Jae Hwa Cho +6 more
openaire +1 more source
Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients [PDF]
European Respiratory Journal, 2005 Matrix metalloproteinase (MMP)-9 and tissue inhibitors of metalloproteinase (TIMP)-1 concentrations are increased in the sputum of asthma and chronic bronchitis patients, and are thought to be related to airflow obstruction. However, serum concentrations of these enzymes have not been clearly evaluated in patients with chronic obstructive pulmonary ...
Y, Higashimoto +7 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen +6 more
wiley +1 more source
Middle East Journal of Cancer, 2018 Background: Egypt has the highest prevalence of hepatitis C virus worldwide. Monitoring hepatitis C-infected patients for hepatocellular carcinoma development is an important clinical issue to diagnose these patients during the potentially curable ...
Ebtsam R. Zaher +4 more
doaj
Advanced Healthcare Materials, EarlyView.ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett +7 more
wiley +1 more source
Neurobiology of Disease, 2011 Previous studies have shown that erythropoietin (EPO) is neuroprotective in both in vivo and in vitro models of hypoxia ischemia. However these studies hold limited clinical translations because the underlying mechanism remains unclear and the key ...
Rhonda Souvenir +5 more
doaj +1 more source
Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids
Advanced Healthcare Materials, EarlyView.Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López +5 more
wiley +1 more source
Egyptian Journal of Chest Disease and Tuberculosis, 2014 Background: Chronic obstructive pulmonary disease (COPD) is a major cause of respiratory morbidity and mortality worldwide. One of the main hypotheses concerning the pathogenesis of emphysema, a key cause of morbidity and mortality in COPD, is the ...
Sherif A. Esa +4 more
doaj +1 more source