Results 21 to 30 of about 153,944 (203)

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity [PDF]

FEBS Letters, 1992
Tissue inhibitor of metalloproteinase (TIMP) was purified and molecularly cloned on the basis of its erythroid‐potentiating activity (EPA). TIMP/EPA appears to be a bifunctional molecule with both growth factor and anti‐enzymatic activity. Recently, a second TIMP‐related molecule was identified and we have investigated its possible erythroid ...
Stetler-Stevenson, William G., Bersch, Noelle, Golde, David W.   +2 more
openaire   +2 more sources

Histopathologic Findings Associated With Matrix Metalloproteinases Proceeding to Recurrence of Primary Spontaneous Pneumothorax in Adolescents

Frontiers in Pediatrics, 2021
Background: Primary spontaneous pneumothorax is potentially life-threatening, and its recurrence is always a serious problem. Pathological examination provides molecular insights into the pathophysiology of primary spontaneous pneumothorax.Objectives: To
Chih-Yung Chiu, Jim-Ray Chen, Shun-Ying Yin, Chia-Jung Wang, Tzu-Ping Chen, Tsan-Yu Hsieh   +5 more
doaj   +1 more source

Prognostic Significance of Matrix Metalloproteinase 2 and Tissue Inhibitor of Metalloproteinase 2 Expression in Prostate Cancer [PDF]

Modern Pathology, 2003
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading the structural support network for normal and malignant cells, promoting neoplastic cell invasion and metastasis. Tissue inhibitors of metalloproteinases (TIMPs) maintain connective tissue integrity by modulating MMP activity.
Jeffrey S, Ross, Prabhjot, Kaur, Christine E, Sheehan, Hugh A G, Fisher, Ronald A, Kaufman, Bhaskar V S, Kallakury   +5 more
openaire   +2 more sources

Metalloproteinase-2 in failed back surgery syndrome caused by epidural fibrosis: can it play a role in persistent pain?

Frontiers in Human Neuroscience, 2023
PurposeFailed Back Surgery Syndrome (FBSS) occurs in 10–40% of patients treated surgically due to disk herniation (DH). There are several factors that can cause a predisposition to FBSS, but the exact pathomechanism has not been elucidated.
Joanna Bielewicz, Beata Daniluk, Piotr Kamieniak   +2 more
doaj   +1 more source

Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation [PDF]

Journal of Vascular Surgery, 2006
Matrix metalloproteinase (MMP)-2 has been shown to play a pivotal role in aortic aneurysm formation. Its activation requires formation of a trimolecular complex of MMP-2, tissue inhibitor of metalloproteinase-2 (TIMP-2), and membrane type 1 (MT1)-MMP, which is attached to the cell surface. At higher concentrations, TIMP-2 becomes an inhibitor of MMP-2.
Xiong, Wanfen, Knispel, Rebecca, Mactaggart, Jason, Baxter, B. Timothy   +3 more
openaire   +2 more sources

Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in diagnosis of pleural effusion of malignant origin [PDF]

, 2016
OBJECTIVES: The aim of the present study was to evaluate the diagnostic accuracy of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in differentiating benign from malignant exudative pleural effusions.
D'Angelo, L., Di Carlo, A., Di Domenico, M., Feola, A., Fiorelli, A., Mazzella, A., Ricci, S., Santini, M.   +7 more
core   +1 more source

The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1 [PDF]

Biochemical Journal, 1991
Human gingival fibroblasts in culture were shown to secrete a 72 kDa progelatinase, of which a proportion in the medium was found to be complexed with tissue inhibitor of metalloproteinases-2 (TIMP-2). A purification procedure was devised to purify free enzyme and inhibitor. We also describe the purification of both 95 kDa progelatinase bound to TIMP-1
R V, Ward, R M, Hembry, J J, Reynolds, G, Murphy   +3 more
openaire   +2 more sources

Relationship between Circulating Serpina3g, Matrix Metalloproteinase-9, and Tissue Inhibitor of Metalloproteinase-1 and -2 with Chronic Obstructive Pulmonary Disease Severity

Biomolecules, 2019
Chronic obstructive pulmonary disease (COPD) is influenced by genetic and environmental factors. A protease-antiprotease imbalance has been suggested as a possible pathogenic mechanism for COPD.
Pelin Uysal, Hafize Uzun
doaj   +1 more source

Kinetics of urinary cell cycle arrest markers for acute kidney injury following exposure to potential renal insults [PDF]

, 2018
Objectives: Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 predict the development of acute kidney injury following renal insults of varied aetiology.
Aliaga, Bellomo, Bihorac, Bonventre, Charlton, Emlet, Goldstein, Gunnerson, Honore, Hoste, Hoste, Jia, Joannidis, Kane-Gill, Kashani, Kaufman, Kerr, Lewington, McDonald, Meersch, Mehta, Mehta, Murrary, Peng, Perazella, Uchino, Waring, Wu   +27 more
core   +1 more source

マトリックスメタロプロテアーゼと膵疾患 [PDF]

, 2001
Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and
Ichimura, Mitsuko, Mitsunobu, Fumihiro, Mizushima, Takaaki, Ochi, Koji, Tanizaki, Yoshiro, Tsurumi, Tetsuya, Yokoyama, Motohiro   +6 more
core   +1 more source