Results 41 to 50 of about 116,173 (199)

Dependence of TIMP-1 plasma levels on preanalytical specimen handling [PDF]

, 2008
Background: Tissue inhibitor of metalloproteinases-1 (TIMP-1) in blood might be a helpful biomarker in various diseases. However, various authors report that TIMP-1 is dependent on preanalytical procedures.
Doss, Robert, Dorothea Nagel, Barry Dowell, Stieber, Petra, Marie Dresse, Dowell, Barry, Dresse, Marie, Robert Doss, Davis, Gerard, Ganser, Eva-Maria, Gerard Davis, Eva-Maria Ganser, Nagel, Dorothea, Petra Stieber   +13 more
core   +1 more source

Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma [PDF]

Iranian Journal of Otorhinolaryngology, 2019
Introduction: Metalloproteinases and their tissue inhibitors play an important role in the metastases formation. A multistage process of carcinogenesis requires the involvement of numerous enzymes and compounds that facilitate the expansion of tumor ...
Pawel Burduk, Piotr Sawicki, Lukasz Szylberg, Magdalena Bodnar, Andrzej Marszalek   +4 more
doaj   +1 more source

Altered expression of metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cervical disc herniation patients

Genetics and Molecular Research, 2016
The aim of the current study was to examine matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in patients with cervical disc herniation (CDH). A total of 127 specimens from CDH patients undergoing posterior spinal surgery were obtained for the case group, which was divided into three subgroups: lateral ...
H M, Zhuang, G T, Xu, S F, Wen, Y Y, Guo, Q, Huang   +4 more
openaire   +2 more sources

Matrix metalloproteinase‐2 promoter and tissue inhibitor of metalloproteinase‐2 gene polymorphisms in non‐Hodgkin's lymphoma [PDF]

International Journal of Cancer, 2011
AbstractSingle nucleotide polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMP) genes are associated with an adverse outcome in some cancers. We examined three polymorphisms: −1306C/T and −735C/T in MMP‐2 and −418G/C in the TIMP‐2 gene, using chain reaction restriction fragment ...
Lan-Ping, Diao, Hui, Ma, Guang-Chuan, Wei, Tao, Li, Hai-Sheng, Liu, Li-Hong, Liu, Li-Li, Wu, Gui-Min, Zhao, Yu-Huan, Gao   +8 more
openaire   +2 more sources

IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) are known for homing to sites of injury in response to signals of cellular damage. However, the mechanisms of how cytokines recruit stem cells to target tissue are still unclear.
Ming-Siou Chen, Cheng-Yu Lin, Yun-Hsuan Chiu, Chie-Pein Chen, Pei-Jiun Tsai, Hwai-Shi Wang   +5 more
doaj   +1 more source

Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]

, 2012
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Notohamiprodjo, Susan, Jaeckel, Carsten, Djafarzadeh, Roghieh, Hofstetter, Monika, Nelson, Peter J., Rieth, Nicole   +5 more
core   +1 more source

Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. [PDF]

, 2012
Mesothelial cells are critical in the pathogenesis of post-surgical intraabdominal adhesions as well as in the deterioration of the peritoneal membrane associated with long-term peritoneal dialysis.
Elfriede Noessner, Susan Notohamiprodjo, Pankaj Goyal, Sauter, M., Sitter, T., Sitter, Thomas, Markus Wörnle, Andrea Ribeiro, Peter J. Nelson (168215), Thomas Sitter, Matthias Sauter (168187), Wolfgang Siess, Wolfgang Siess (168198), Susanne Himmelein, Nelson, P.J., Himmelein, Susanne, Thomas Sitter (168211), Goyal, P., Sauter, Matthias, Susanne Himmelein (168206), Nelson, Peter J., Markus Wörnle (168201), Susan Notohamiprodjo (168192), Ribeiro, A., Notohamiprodjo, Susan, Elfriede Noessner (146689), Noessner, Elfriede, Wörnle, Markus, Djafarzadeh, Roghieh, Roghieh Djafarzadeh, Matthias Sauter, Nößner, E., Andrea Ribeiro (168203), Roghieh Djafarzadeh (88033), Himmelein, S., Peter J Nelson, Wörnle, M., Goyal, Pankaj, Ribeiro, Andrea, Djafarzadeh, R., Notohamiprodjo, S., Pankaj Goyal (156516), Siess, W., Siess, Wolfgang   +43 more
core   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Characterization of the functional domain of tissue inhibitor of metalloproteinases-2 (TIMP-2) [PDF]

Biochemical Journal, 1993
Analysis of the functional domain of tissue inhibitor of metallo-proteinases-2 (TIMP-2) was performed using limited proteolytic degradation with trypsin. This treatment generated a 13.5 kDa fragment which was purified and shown to consist of an uncleaved N-terminal region extending from residue 1 to residue 132.
Y A, DeClerck, T D, Yean, Y, Lee, J M, Tomich, K E, Langley   +4 more
openaire   +2 more sources

Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population

BMJ Open Diabetes Research & Care, 2020
IntroductionThe non-invasive enhanced liver fibrosis (ELF) score—comprising tissue inhibitor of matrix metalloproteinases-1 (TIMP1), hyaluronic acid (HA) and amino-terminal propeptide of type III procollagen (PIIINP)—has been shown to accurately predict ...
Yeli Wang
doaj   +1 more source