Results 31 to 40 of about 153,944 (203)

Matrix metalloproteinase‐2 promoter and tissue inhibitor of metalloproteinase‐2 gene polymorphisms in non‐Hodgkin's lymphoma [PDF]

International Journal of Cancer, 2011
AbstractSingle nucleotide polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMP) genes are associated with an adverse outcome in some cancers. We examined three polymorphisms: −1306C/T and −735C/T in MMP‐2 and −418G/C in the TIMP‐2 gene, using chain reaction restriction fragment ...
Lan-Ping, Diao, Hui, Ma, Guang-Chuan, Wei, Tao, Li, Hai-Sheng, Liu, Li-Hong, Liu, Li-Li, Wu, Gui-Min, Zhao, Yu-Huan, Gao   +8 more
openaire   +2 more sources

Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury. [PDF]

, 2018
BACKGROUND:In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activity after ...
Angert, Mila, Chernov, Andrei V, Dolkas, Jennifer, Hullugundi, Swathi K, Remacle, Albert G, Shubayev, Veronica I, Strongin, Alex Y   +6 more
core   +2 more sources

Tissue Inhibitor of Metalloproteinase‐2 Gene Delivery Ameliorates Postinfarction Cardiac Remodeling [PDF]

Clinical and Translational Science, 2011
Abstract Hypothesis: Adenoviral‐mediated (AdV‐T2) overexpression of TIMP‐2 would blunt ventricular remodeling and improve survival in a murine model of chronic ischemic injury. Methods: Male mice (n = 124) aged 10–14 weeks underwent either (1) left coronary artery ligation to induce myocardial infarction (MI group, n = 36), (2 ...
Ravi, Ramani, Kathleen, Nilles, Gregory, Gibson, Benjamin, Burkhead, Michael, Mathier, Dennis, McNamara, Charles F, McTiernan   +6 more
openaire   +2 more sources

The Distribution of Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-4 in Psoriatic Skin

British Journal of Medicine and Medical Research, 2015
Aims: To evaluate the appearance and distribution of matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase-2 (TIMP-2) and tissue inhibitor of metalloproteinase-4 (TIMP-4) in lesional skin biopsies of psoriasis patients. Study Design: Observational study.
Elga Sidhom, Mara Pilmane, Janis Kisis
openaire   +1 more source

Relationships between markers of extracellular matrix degradation and systemic inflammatory response among patients with acute myocardial infarction

Сучасні медичні технології, 2020
Despite all the preventive, diagnostic and therapeutic possibilities of our time, diseases of the circulatory system are the leading causes of death among adult population both in the world and in Ukraine.
E. V. Sid, V. V. Litvinenko
doaj   +1 more source

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. [PDF]

, 2016
The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a
Cieplak, Piotr, Ge, Xin, Nam, Dong Hyun, Remacle, Albert G, Shiryaev, Sergey A, Strongin, Alex Y   +5 more
core   +1 more source

Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia [PDF]

Disease Markers, 2014
Aim. To study the immunohistochemical expression of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase-2 in different histological grades of tobacco associated epithelial dysplasia and correlate the association between these proteases.
Dipshikha Bajracharya, Bijayatha Shrestha, Asha Kamath, Aparna Menon, Raghu Radhakrishnan   +4 more
openaire   +2 more sources

LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism [PDF]

, 2016
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Bachert, Claus, Claeys, Cindy, Holtappels, Gabriële, Perez Novo, Claudina, Pezato, Rogerio   +4 more
core   +2 more sources

Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 [PDF]

Proceedings of the National Academy of Sciences, 2002
Matrix metalloproteinases (MMPs) are a family of multidomain enzymes involved in the physiological degradation of connective tissue, as well as in pathological states such as tumor invasion and arthritis. Apart from transcriptional regulation, MMPs are controlled by proenzyme activation and a class of specific tissue inhibitors of metalloproteinases ...
Ekaterina, Morgunova, Ari, Tuuttila, Ulrich, Bergmann, Karl, Tryggvason   +3 more
openaire   +2 more sources

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice [PDF]

, 2015
Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor ...
A Dufour, A Gutierrez-Fernandez, A Gutiérrez-Fernández, A Krüger, AM Tester, Ana Gutiérrez-Fernández, B Fingleton, B Fingleton, C López-Otín, C Soria-Valles, CM Overall, CT Guy, D Agarwal, Dylan R Edwards, E Dejonckheere, EI Deryugina, EM Bekes, EY Lin, EY Lin, G Christoffersson, G Dew, H Nozawa, J Decock, J Decock, J Decock, J Decock, J Schindelin, J Wyckoff, JE Maglione, JP Väyrynen, JP Witty, JT Korpi, JT Korpi, Julie Decock, K Almholt, L Sevenich, LH Palavalli, LJ McCawley, M Balbin, M Egeblad, M Hernández, M Lin, M Zhu, MM Gueders, N Fortelny, N Xu, P Li, P Lint Van, S Tazzyman, S Thirkettle, Sally Thirkettle, Stephen D Robinson, T Pellinen, T-Y Wu, V Knäuper, V Montel, W Wang, Wouter Hendrickx, Y Lang, Y-H Lin, Z Yang, Z-G Zhao, ZG Fridlender   +62 more
core   +3 more sources